Tag Archives: fractures

WHY PRESCRIBE OR TAKE FORTEO- TERIPARATIDE FOR OSTEOPOROSIS?

question: how can I afford Forteo?

Answer: why on earth prescribe or use  a synthetic like Forteo? with all it’s risks eg  see http://www.umm.edu/altmed/drugs/teriparatide-121950.htm; and   http://www.drugs.com/forteo.html :
“What is the most important information I should know about Forteo?
This medication has been found to cause an increased risk of bone cancer in animal studies. It is not known if this risk is also increased in humans treated with Forteo. Talk with your doctor about your individual risk.Forteo can cause side effects that may impair your thinking or reactions. ”

So  Insurance is right not to pay for it- all it benefits is the manufacturer, prescriber and dispenser. There do not seem to be any published followup data for Forteo beyond 3 years- not surprising since it involves daily injection at gigantic cost, and was only invented in 2002.  Look at the lesson of bisphosphonates- increasing reports of bone (jaw, long bone) collapse since 1995.

Remember- the chief risk factor  for fractures with osteoporosis is not low bone density but falls- inco-ordination and muscle frailty. So rather use permanently the basket of  safe lowcost natural dozen anabolic supplements  (including vitamins, minerals, proline and appropriate HRT) that protect ALL aging  systems, detailed in previous papers under  https://healthspanlife.wordpress.com/category/osteoporosis/

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CRIES OF INFECTION WOLVES, AND OFFICIAL ONGOING DENIAL OF NECESSARY PREVENTION:

It’s tragicomedy that the BBC – the quintessential British spokespersona – laments NHS woes: * UK c.diff deaths ‘rising sharply’ * “The equivalent of one person an hour dies in hospital from clostridium difficile, figures suggest.”

And yet Authorities there and mostwhere are still in denial about enforcing simple safe low-cost multi-system prevention – in this instance to keep people out of bed and hospital, off antibiotics.
Authorities- regulators, politicians, the Tax Man – benefit as hugely from disease as do their fairy godmother the Disease Industry- the Drug conglomerates and their researchers and lobbyists, private hospitals, medical schemes – that pay them handsomely and creates myriad factories and jobs.

So because it is not profitable, Prevention Does Not Pay, no matter that it adds decades to health:

*There is no move to ban smoking, to make it (and sale, and allowance thereof) a criminal offence.

*No move to immediately jail drunken drivers for a long time, and on second offence permanently confiscate their driving licence and ban them permanently from current and future public office and public vehicle driving, be they judges or janitors, cabinet ministers or cabbies.

*The banning of deadly polluting coal-and oil-powered vehicles and major electricity sources has been blocked for decades by the endlessly greedy and ruthless oil-based industry magnates, despite the fact that these finite energy sources are desperately needed for other purposes. Now the world faces immediate famine because the oil-based transport-and energy behemoths (who have blocked investment in natural – solar – energy for decades) are paying bigger dollars for crop and marine resources as energy supplies than most consumers can afford to pay for these finite resources as food.

*No official move to acknowledge that the best drugs for both prevention and chronic treatment are the long-proven natural low-cost vigorous safe daily doses of a few score appropriate micronutrient supplements – vitamins (~15), minerals(~10) and biologicals (human and other species’) that are increasingly inadequate in the food chain in longer-lived increasingly overweight stressed humans facing worsening man-made epidemics and environmental disaster.

*No serious move yet by the US FDA- the chief protector of the new drugs industry of the west -English- Europe- Japan – (against the interests of consumers) to enforce integrity, insist that no chronic designer drugs for the chronic major common degenerative diseases be released for general use until they have been proven both at least as safe and effective as those already existing and effective, in major randomised controlled trials of a mean of at least 8years, head to head against both older designer drugs, and long-proven natural drugs, for similar purpose, in those diseases.

*The past decade alone has seen condemnation of myriad unproven unnecessary and risky released drugs –
on Wikipedia alone at least a dozen – eg Propulsid; cerivastatin; Vioxx; pemoline; benzbromarone; torcetrapib; and the discrediting of the non-steroidal anti-inflammatory drugs as no better – and potentially more hazardous than- appropriate cortisone and micronutrient use, and
newer designer antidepressants and anticlotting agents as less safe and effective than appropriately used older ones;

*the unnecessary anti-osteoporosis bisphosphonates that are increasingly associated with the very long-bone fractures they are supposed to prevent;

*and most especially the wannabe oral anti-diabetic anti-atheroma and anti-obesity drugs – statins, rimonabant, glitazones, meglitanides and sulphonylureas – as inferior to and less safe than metformin, the 85year old plant extract which is the only designer drug ever proven as invaluable panacea in a 20year RCT, tested against sulphonylureas, but not against all other modern designer drugs which (as in more recent studies) have never been shown to meaningfully reduce all-cause morbidity and mortality as does metformin.

The until-recent FDA haste to licence new drugs after scanty trials was reminiscent of the criminal conspiracy between the FDA and industry that licenced the already contested diethylstilbestrol Chicago trial of 1950- and kept that drug on the market another 25years after it was discredited. And it was in stark contrast to the FDA (to protect USA drug companies) blocking drugs already in highly effective use elsewhere for decades, like lithium carbonate, metformin and betablockers.

Since no drug corporations promote the out-of-patent old and proven agents, authorities cannot afford to promote truth – that the only remedies for chronic prevention that lower all-cause disease and mortality by between a third and a half – overweight, obesity, diabetes, cancer, hypertension, arthritis, osteoporosis fractures, vascular disease, acute infections, depression, dementia – are:

-fish oil a few grams a day- which also drastically lowers behavioural and learning disorders;
-a lowcost simple blend of a few score other proven natural micronutrients – the fifteen vitamins, ten minerals and the human / other species’ biologicals including herbs;
-metformin titrated to tolerance about 2.5gms a day, for both prevention and treatment of overweight, diabetes type 2 and most major chronic degenerative diseases; &
-appropriate conservative balanced sex hormone replacement in most older men and women, as proven in the landmark Womens’ Health Initiative and Finnish Oulu randomised controlled trials, and numerous other studies in major centres in North America, UK, Europe, Australia and South Africa, since 1953.

It is a tenet of endocrinology for the past 60 years that all major hormone deficiencies should be replaced permanently and physiologically with the same human hormones, yet there are still those, even medical specialists, who would deny this to those most in need – from middle age onwards, especially women. At least some of these specialists have the honesty to disclose that they are well paid by drug compnies to be advocates and trialists for the wannabe designer drugs to supplant the old.

Recognition of appropriate measured low cost HRT and the other proven listed supplements for all aging people would of course rob the drug industry of perhaps 90% of it’s market for it’s wannabe designer substitutes that the FDA allows to be marketed prematurely until enough people die of their complications or shortcomings.

In fact, while no study shows that any modern drug for common chronic degenerative disease prevention does any overall – mutidisease- good, reduces all-cause mortality, those who promote and practice such published truth – that the old is better – are threatened with prosecution.

UPDATE: VITAMINS vs LACK OF EFFECTIVENESS OF MODERN DESIGNER DRUGS FOR DEMENTIA

LACK OF EFFECTIVENESS OF MODERN DESIGNER DRUGS FOR DEMENTIA. VIVA VITAMINS .

21 Sept 2014  update:  a new USA study Littlejohns, Llewellyn ea,  confirms  low Vitamin D  risk of dementia and Alzheimer disease.Neurology. 2014 Sep;83:920-8, that in 1658 USA elderly followed for ~5.6years, dementia more than doubled in those with baseline vit D level below 10ng/ml compared to those above 20ng/ml.

This confirmed the 2012 Angers study Annweiler Beauchet ea that the elderly with the highest  quintile of vitamin D intake had only 23% of the risk of AD of those in the lowest quintile.

So while there are numerous obvious reversible and avoidable causes for dementia, – syphilis, stroke, malnutrition   and poisoning known for millennia – on Pubmed vitamin D and dementia link  dates  back to 1968.  Vitamin D3 and  vitamin B12 supplements are two of the cheapest and safest to give since even a monthly or 3monthly shot – if not simply oral vit D3 orally fortnightly- can maintain good repletion, quality of life and longevity; while hugely reducing multisystemic diseases and infections. . .

Wikipedia still says soberly Currently, no medications have been shown to prevent or cure dementia.    By that they mean designer for-profit prescription drugs.

24 March 2008:  it took 8 authors (funded by the U.S. and Ontario Ministries of Health and McMaster University) 19 pages in a leading journal this month to show what has been obvious the past decade from Medline –
that the modern anti-dementia drugs produce clinically significant adverse effects but zero clinically meaningful benefit or remission/slowing of degenerative dementias.

This article highlighting the futility and irrelevance (as in arthritis; type 2 diabetes; osteoporosis; lipid- vascular disease, cancer) of modern designer drugs for prevention of everyday chronic degenerative aging diseases is truly POEM – Patient-Orientated Evidence that Matters

But does it need a massively costly study to show what has been obvious from every single published trial of these drugs?

Surely these anti-dementia drugs should be banned since their risks outweigh their benefits?
Talk about fiddling for a living.

Yet while appropriate long term sex hormone therapy the past >50 years for both sexes clearly lower (by perhaps 40%) the risk of dementia, fractures, vascular disease and all-cause premature deaths, with negligible risks, bureaucrats continue to insist that it must not be used longterm until major trials have proven it- which trials will never be done because these supplements are long out of patent.

One must ask again whether the bureaucratic bodies (professional associations, universities, Regulators, medical schemes, politicians) that strive to have effective safe supplements (HRT, vitamins, minerals, biologicals including fish oil, herbs) severely restricted – or made prescription only – are fearlessly independent of the massive financial inducements, lobbying power of the New Drug Industry on behalf of their wannabe substitutes for old supplements that work?

http://www.annals.org/cgi/content/full/148/5/379 Ann Intern Med. 2008 Mar 4;148:379-97.
Effectiveness of cholinesterase inhibitors (donepezil, galantamine, rivastigmine, and tacrine) and memantine for treating dementia: evidence review for a clinical practice guideline. Raina P, Santaguida P, Ismaila A, Patterson C, Cowan D, Levine M, Booker L, Oremus M. McMaster University, Hamilton, Ontario, Canada.