Tag Archives: DHA

WHO SAYS LARGE DOSES OF NATURAL MARINE OIL ARENT MAJOR HEALTH BENEFIT?

who says Large doses of fish oil don’t prevent heart attack or stroke?

update 8 August 2013 the  OregonUniversity Linus Pauling Institute website still promotes the numerous benefits of fishoil.

update 2 August 2013    the Topol- Rowen- Peskin rejection of need for  fish oil EPA+DHA was  not supported by the recently NEJM-published  R&P 5 year trial in Italy, which compared  modified ie patented ethylester marine essential fatty acids with olive oil.

This R&P  trial was thus not a trial of fish oil (concentrate or otherwise), nor placebo-controlled, since olive oil is hardly a placebo- in the 13.4year Spanish EPIC trial  published last year , olive oil dramatically reduced all-cause mortality by 1/4 and CVD mortality by 44%. The full 2013 NEJM R&P paper is inexcusably silent in omitting this cardinal fact that it was no ways placebo-controlled- placebo means an inert comparator.

Thus  it can only be concluded from the Italian R&P trial that addition of patented processed EthylEster EFAs for only 5 years  gives no more benefit than the already major protection of olive oil and  mediterranean lifestyle alone. Contrary to Topol-Rowen-Peskin, this  R&P trial says nothing about the longterm benefits of vigorous fish oil intake in a high-risk population eg in USA/ other populations (especially smokers)  not  on a mediterranean/ Asian  high-fish intake.

the 2010 Nordic study ( Dyerberg  ea  Copenhagen University- who first reported in 1978 the association between marine omega3 PUFA and health in Eskimos) http://www.nordicnaturals.com/images/pdfs/tgstudy.pdf details the better bio-availability of natural ie triglyceride- bound fish oil- EPA+DHA compared to that in processed ethylester low-triglyceride omega3 products-   as used in the R&P and GISSI trials of patented commercial designer products. .

2 June 2013 Its some 4 years since this healthsite started promoting marine oil for optimal development and health.

    what say you to the latest hype about the  predictable negative result of the Italian N-3  Cardiovascular Risk and Prevention trial  R&P from the NEJM? ie that omega3 oil was no better than olive oil.
the major problem is that the R&P trial didnt use  natural clean FISH OIL, nor    in primary prevention.
Nowhere does it say it used fish oil- it says N-3 ie omega3, and in patients with multiple vascular disease. Nor does the original 2010 R&P plannng paper  state that in fact  it used  a patent formula of  chemically changed ethyl esters in tertiary  prevention,

like the GISSI trial used apparently patent branded altered  Om3  after heart attacks – it wasnt  natural clean fish oil..
the GISSI abstracts 1999 and 2008 also dont mention fish oil.
 So  it wasnt natural   fish oil  like I use and promote- clean codliver oil or clean om3  concentrate from clean factories in northern Europe and now even from Cape Town..  The R&P abstract paper cleverly doesnt mention  the brand Omega3  name- but Pfizer funded the trial…
Its the “top” journals  likely up to their  old tricks, publishing probable infomercials paid for in this case by Pfizer and mates,  without making that clear.
I cant see if these Italian trials used Lovza/Omacor or whatever  Big Pharma  chemically altered snakeoils.
But looking at the extensive debate already around Dr Topol’s condemnation of real fishoil  supplement,   many commentators  fell into the same trap- they didnt notice that  R&P didnt use fish oil, but about 850mg/day  ethyl esters of omega3.

Synthetic patent designer drugs dont do what the natural  food/supplement/human biophysiologic product  does.

   Ethyl esters eg ethinylestradiol, and xenohormones eg Premarin,  are  dangerously different from  estradiol.  Look at the controversy, the danger in using  altered natural products eg:
slowrelease niacin instead of natural niacin.
or  neurontin/lyrica or benzos  instead of natural  GABA to bind to the GABA receptors.                                                                                  or  anabolic steroids eg methyltestost instead of testosterone.         or methylprogesterone Provera instead of progesterone.                 or margarine instead of butter !.                                                             or  methanol  –   dangerously different from  ethanol;                        or synthetic substitutes for natural digoxin…      

or the Women’s Health Initiative- which through gross misrepresentation stopped many women from using beneficial physiological human HRT for 10 years, despite the bad design of the WHI that used  long-proven risky xenohormones (premarin, provera) at dangerous older age, while in the first 6 years it enormously benefitted women in the first decade after menopause.. .

It’s  dis-ingenouos of Messrs Rowen,  Topol  and Peskin  not to state this, that the R&P TRIAL  DIDNT USE FISH OIL..
Dr Rowen and Mr Peskin are heavily promoting their own PEO Parent Essential Oil  Brand of Omega6 plant oils. The evidence is that such combination is excellent benefit- but I see no science, no reason not to balance it with clean fish oil since this is now so deficient in general diet.
But surely Prof Topol is doing patients a huge disservice in backing the R&P trial in dumping fish oil  -when that trial didnt use fish oil, and makes no conclusion about fish ol?

I await the full  copy of the R&P study – which the NEJM mysteriously doesnt  make available on line as they usually do with any seriously important  new  study.. .

No-one doubts that good plant oils , good mixed diet have benefit.
there is no doubt that a few gms of fish oil a day have huge  benefit.
Its the balance that matters- and the avoidance of  smoking, sloth, adiposity, refined sugars and cooked animal fats that matters.
so I see no reason to change from taking/ recommending   daily  a tsp (or 4)   of codliver oil (ie about 800 – 3000mg EPA+DHA) ,
and olives/ mixed nut/plant/olive oils on salads/pasta etc ,
     and a tsp of DMSO, and  2 tsp coconut oil/day.
   A recent Australian paper analyses usefully the growing problem of dwindling resources and  the inestimable health importance   of marine  oil – but does not mention viable  marine  om3   synthesis. Like a cure for HIV-AIDS,  the latter  is an elusive  improbability.  .  There is still no objective independent eg  Cochrane review of  prescription omega-3-acid ethyl esters (P-OM3), despite Omacor being on the market for over 20 years .  Why is this?
      Wikipedia specifically notes that  Lovaza/Omacor  has not been shown to lower the rates of all cause mortality and cardiovascular mortality, or the combination of mortality and non-fatal cardiovascular events.[3]It is .. fishoil that has been  chemically altered”…  and the USA FDA still hasnt licensed such derivatives for anything but severe hypertriglyceridemia.   And the US Supreme Court banned patenting of any natural marine oil extract.  Whereas in stark contrast, unpatentable  natural marine omega3  EPA+ DHA–   clean  marine  oil- lowers all  major morbidity  from conception,  and all-cause mortality.

what say you?…

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Forbidden Medicine? Vitamin C-lecithin-fish oil- bioflavonoid interactions in the prevention of atherosclerosis, cancer and gallstones.

neil.burman@gmail.com

IS THERE ANYTHING NEW UNDER THE SUN?

Fish oil use for medicinal as well as dietary purposes  dates back at least to Viking times; but the 1922  scientific study of fish oil by Jack Drummond & Sylvester Zilva is the first paper on it on Pubmed, as a source of vitamin A.

But  in this ‘scientific’ era it took till the 1930s for fish  (ie codliver) oil’s  wide medicinal benefits  to be recognized.

Since then fish oil has proven to be the most pluripotential ‘micro’nutrient – at a dose as little as perhaps 100mg/day- in prevention and treatment (via either it’s omega3 EPA+DHA content, or its vitamins A and D content) of all common major diseases from learning , behaviour and memory disorders from birth to dotage, to infections, inflammation, arthritis, vision, pregnancy,  growth and osteoporosis, mood, Parkinson’s, hypertensive, vascular, thrombotic, lipid, cancer and diabetic disorders – probably halving all-cause ‘natural’ aging mortality.

The recognition of citrus juice- vitamin C – as a medicinal dates back apparently only 250 years to Dr James Lind’s recognition of it’s reversal of lethal scurvy. But it was first identified and isolated only about 80 years ago .  Since then it has proven to be as pluripotential a preventative as fish oil and now vitamin D3, and balanced sex hormone replacement.

The 1940s give the first reference  on Pubmed to bioflavonoids-which are anti-allergic, anti-inflammatory, anti-microbial, anti-cardiovascular disease, anti-varicose veins, anti-piles  and anti-cancer- and promote the absorption of vitamin C.

In 1971 Borgman & Haselden described the  effects of cod liver oil on dissolution of gallstones.

from 1973 Cameron Pauling & Campbell published their landmark work on vitamin C to tolerance (not antiscurvy doses or below many grams a day) in the prevention and treatment of many human cancers.

In 1974 Krumdieck & Butterworth’s landmark  paper on cholesterol-lecithin interactions: factors of potential importance in the pathogenesis of atherosclerosis. summarized the evidence for combining supplements of vitamin C and soy lecethin (ie polyunsaturated fatty acid at position 2)  in the prevention of atherosclerosis- since once this disease is present, it can take months to reverse.

in 1976  Navarro & Guevara described the importance of vitamin C in prevention of gallstones.

and by  1989 Wechsler  ea described how omega-3-fatty acids  – fish oil–  just 1.5gm a day decreases biliary cholesterol and lithogenicity.

by 1997 Mizuguchi ea described prevention  by fish oil of cholesterol gallstone formation in hamsters.

and in 1999  Takenaga ea described how Lecithinized ascorbic acid (PC-AS) effectively inhibits murine pulmonary metastasis.

Lecitithin is derived from food – meat, liver, legumes, cereals, fish and eggs – but not from fish oil.   It – phosphatidylcholine- is a principal component of fat metabolism, cell membranes, brain, semen, and against gallstones, atherosclerosis (and thus heart – vascular-hypertensive -brain-), breast,  cirrhosis and other liver diseases.

The crucial DHA and EPA omega3 fatty acids are, practically, derived exclusively from marine algae and thence krill and fish oil .

Hence the paramount importance (in preventing all common diseases)  of promoting fish oil (by the teaspoon or capsule) together with lecithinized Vitamin C to tolerance eg  vitamin C 50% enhanced with perhaps 15% calcium carbonate,  5% mag oxide,  10% bioflavonoid and 20% lecithin. Up to a heaped  tsp 2 – 3 times  a day of such an Enhanced Vitamin C  mix – ie to bowel tolerance- will provide 5 – 7.5g vitamin C, 500-750mg calcium, 300 -450mg magnesium, 1-1.5g bioflavonoid and 2- 3g  lecithin, without diarrhoea.

This self-degassing self-emulsifying blend puts within reach orally the eg 1gm/kg vitamin C per day vitamin C to produce the high enough plasma levels of vitamin C that have  been shown to be lethal to cancer cells in vitro and in vivo. For the much higher doses of vitamin C for this purpose eg 30gm daily, some  of the calcium and magnesium obviously need to be replaced with sodium to avoid 3000mg/day calcium and 1800mg/day  overdose.

Adding say 1tsp cod liver oil to half a glass of water with eg 3tsp of the powder blend (ie 6gm vitamin C) and beating it produces a smoothie emulsion  that is easy to drink. Who needs fish oil capsules now?. And there is  virtually no limit to the  amount of lethicinized calmag ascorbate – bioflavonoid omega3 emulsion  that can be poured into the body to combat eg infection, atherosclerosis and cancer.

Obviously to this should be added a blend of all the other few-score safe proven potential preventative supplements to combat all the other chronic diseases of premature aging including even multiple sclerosis (especially highdose vitamin D3).

So while oil and water dont usually mix in a glass, ie vitamin C and bioflavonoids are soluble in water but  not in  oil, combining them by taking them  together with lecithin, fish oil and calmag (to lessen acid load with  better absorbed calmag ascorbate) a few times a day makes huge sense for all disease prevention let alone support..

And none of it is news.

But the farce from  “authorities”- ‘Regulators’ (who are paid big protection money by Drug Companies)  – is that labels, marketing materials are  not allowed to say that cheap harmless food supplements prevent let alone treat disease!..

And “Authorities” want to regulate (or put on doctors’ prescription only) safe medicinal  food supplements when they will not ban   the biggest killer  drugs-  like DDT, PCBs,  PVCs (and other estrogenics eg from the highdose xenoestrogens & -progestins consumed  orally by possibly a billion women and excreted into the water chain to pollute land and sealife) ie  throughout the environment and  food chain; and  stuffing sodas and  processed foods with cornstarch, aspartame and phosphates; and over-the-counter refined sugar and salt, smoking tobacco and alcohol which should at best be made  prescription- or permit-only .