Category Archives: H1Ni swine flu

FIGHTING INFECTION NATURALLY IN THE POST-ANTIBIOTIC ERA

FIGHTING INFECTION NATURALLY IN THE POST-ANTIBIOTIC ERA: SALUTE DR IGNAZ SEMMELWEIS

TRIBUTE:  to pioneer  Dr Ignaz Semmelweis martyred 150years ago by his jealous Viennese colleagues for shaming them by  saving  mothers’  lives with good hand hygiene- chlorine disinfection-  from childbirth fever  .

At no time in the past century of synthetics has natural infection control been more important; up to WW1 and the 1918-19 Influenza pandemic, infection killed more more armies of men than warfare itself.

Now  one  in three deaths in “western”  hospitals are  attributed to hospital-acquired antimicrobial  resistant bacterial (eg MRSA, MTB),  fungal  and now vital (eg HIV) infection;

and antivirals and vaccines anything but  eradicate serious HIV, flu, HSV, HPV, ebola, malaria, hepatitis, CMV,  etc.

Because of antibiotic harms, we increasingly have to advise patients against antibiotics for non-purulent respiratory- ENT, skin, gastrointestinal and genitourinary  infections since these are so often viral/ allergic.

But (apart from good hygiene),  given clean food, water and sanitation, the low-cost umbrella of proven safe natural immune boosters can at least halve infection rates, severity and thus deaths.

ph or email for appointments:  neil.burman@gmail.com; personal +27836299160.  fax+27865657215 Preferred provider contracted to major medical schemes.

Natural Medicine Clinic

1st floor, 15 Grove Bldg, Grove Ave, Claremont 7708. ph 021 6831465 office hours.

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SWINE FLU UPDATE . ODDS OF DYING OF SWINE FLU 1 IN A MILLION? WHY REGIONAL DIFFERENCES IN MORTALITY? WHY KAFKAESQUE U.S.GOVT.RESPONSE?………… IF SWINE FLU IS RAMPANT IN N.AMERICA,………… WHY STILL NO CLINICAL VACCINE TRIAL RESULTS? WHY THE CONSPIRACY TO AVOID RCT OF CLINICAL EFFICACY OF S.F.VACCINE?

neil.burman@gmail.com Cape Town

update 24 Feb 2914   Todays JAMA on-line- first prerelease article about  the current resurgence of Critically Ill Patients With Influenza A(H1N1)pdm09 Virus Infection in 2014 laments its high deathrate  from acute respiratory and multiorgan failure adults in young adults,  and its guarded response to antiviral designer drugs like Tamiflu.   But it fails to mention vitamins and minerals, although these have dramatic benefit in both preventing infections, and treating flu,  AIDS and  TB.

Flu season: Vitamin D versus H1N1 Flu ,    Hormones Matter and Vit C cures H1N1  highlight the safety and efficacy of vigorous vitamin D  & C repletion, never mind when combined with other antimicrobial supplements like the other vitamins, and the minerals selenium, zinc, iron, iodine, and antimicrobial plant extracts like sutherlandia and  galega officinalis etc.

Guess which Big Pharma is the biggest manufacturer of vitamins in the world? Roche. and guess  which company makes Tamiflu?   Roche–  which refused to release the data from all of its trials, the adverse effects far exceeding its benefits.

But nutritional supplements are not patentable, so they are studiously ignored by the Disease Industry for whom only profit matters.

More about the lethal effect of deriding and suppressing good remedies under the-2014-virus-season-dawns-avoiding-the-semmelweis-reflex-natural-antibiotics-vitamins-c-d3-avoiding-vitamin-denialism –  The Semmelweis Reflex.

update 16 Feb 2014: it’s taken 5 years, but at last the fraud of  Big Pharma and the Regulators, Governments they support is being exposed in more depth:

the Swine Flu pandemic of 2009- set up by the Vaccine Industry paying vast bribes to world Regulators and Governments-  to promote the useless if not risky flu vaccine and Tamiflu drugs, is being confirmed and investigated, as reported by www.NaturalNews.com email newsletter: Even the science journals are now investigating the total scam of the WHO’s flu pandemic fear mongering. Here’s what you need to know: http://www.naturalnews.com/043932_Big_Pharma_World_Health_Organization_flu_scam.html 

and the wider Multiple Vaccine MMR fraud affecting especially infants and children (the gastroenteropathy- Autism link), that has been centre stage for 15 years, is analysed in detail by Dr Andrew Wakefield in his new book Callous Disregard.

Update 15 January 2010: current commentaries:                                                   Mary budinger@earthlink.netn is quoted as writing:

INQUIRIES GET UNDERWAY INTO CONFLICTS OF INTEREST Governments heeded warnings from the United Nations that there would be millions of deaths unless nations promptly proceeded with the controversial vaccination plan promoted by the UN’s entity for health matters, the WHO. With billions of dollars of unneeded inventory now going to waste, government leaders turned angry and started to demand hard answers.

Articles in the European press have repeatedly called into question the myriad ties between vaccine manufacturers and decision makers in the WHO.

The French opposition Socialist Party described that country’s national campaign as an “extravagant fiasco” and demanded a parliamentary investigation.

In early January 2010, the Council of Europe member states announced they are launching an inquiry into the influence of the pharmaceutical companies on the global swine flu campaign, focusing especially on extent of the drug industry’s influence on WHO. The text of the resolution says, in part, “In order to promote their patented drugs and vaccines against flu, pharmaceutical companies influenced scientists and official agencies, responsible for public health standards, to alarm governments worldwide and make them squander tight health resources for inefficient vaccine strategies and needlessly expose millions of healthy people to the risk of an unknown amount of side-effects of insufficiently tested vaccines. The ‘bird-flu’-campaign (2005/06) combined with the ‘swine-flu’-campaign seem to have caused a great deal of damage not only to some vaccinated patients and to public health-budgets, but to the credibility and accountability of important international health-agencies.”[1]

The WHO’s “false pandemic” flu campaign is “one of the greatest medicine scandals of the century,” according to Dr. Wolfgang Wodarg, Chairman of the Parliamentary Assembly of the Council of Europe. “The definition of an alarming pandemic must not be under the influence of drug-sellers,” he adds.

Wodarg, a doctor and former SPD member of the German Bundestag, says that the “false pandemic” campaign began last May in Mexico City, when a hundred or so “normal” reported influenza cases were declared to be the beginning of a threatening new pandemic, although there was little scientific evidence for this. Nevertheless the WHO, “in cooperation with some big pharmaceutical companies and their scientists, re-defined pandemics,” removing the statement that “an enormous amount of people have contracted the illness or died” from its existing definition and replacing it by stating simply that there has to be a virus, spreading beyond borders and to which people have no immunity.

These new standards forced politicians in most states to react immediately and sign marketing commitments for additional and new vaccines against swine flu, through “sealed contracts” under which orders are secured in advance and governments take almost all responsibility. “In this way, the producers of vaccines are sure of enormous gains without having any financial risks. So they just wait until WHO says ‘pandemic’ and activate the contracts,” says Dr. Wodarg.[1]

The Japanese health ministry announced it is launching an inquiry into deaths and side effects from the vaccine. Japan recorded 104 deaths, roughly 80 percent of whom are people aged 70 or older who had chronic diseases or disorders. Additionally, some 1,900 cases of side effects had been reported from medical institutions.

In the U.S., President Obama had decreed the H1N1 pandemic a national emergency, prompting some analysts to warn about increased governmental powers. The U.S. Department of Health and Human Services had issued a “formal declaration of a Public Health Emergency” in April of 2009, even though there had only been 20 confirmed cases of the H1N1 virus.

To date, the U.S. has not followed in the footsteps of the Council of Europe.
[1] http://www.pharmatimes.com/WorldNews/article.aspx?id=17147

William Campbell Douglass II, M.D. writes:

How Big Pharma profits off fear            With Big Pharma raking in billions off swine flu fears, the last thing they need is a government handout.

Yet Uncle Sam is busy playing Daddy Warbucks with YOUR lunch money, helping Swiss drugmaker Novartis open a new vaccine plant in North Carolina. You’ve generously contributed around $700 million to help Novartis build their shiny new drug factory — $220 million three years ago, and $486 million this year.

And I’ll bet you didn’t even get a thank-you card.

In return for this bad investment in a foreign company, the U.S. government gets the right to PURCHASE vaccine for 17 years. Not only that, but these vaccines will be created using a new and unproven biotech method that relies on dog kidneys instead of chicken eggs.

In other words, this plan really is a dog.

I’m a doctor, not an economist. But if this is someone’s idea of stimulus, you do the math: The plant now employs 191 people making an average of $50,000 per year. At that rate, it would take around 75 years for the government money put into this joint to make its way back into our own economy.

Slice off a few years if you believe them when they say they’ll ultimately employ 350 people when the plant is fully operational in 2013 — in any case, it’ll be decades before Americans ever see that cash again.

But don’t worry — I’m sure somewhere, a poor Swiss ski resort is hosting a group of free-spending Novartis executives.

Maybe they’ll be joined by their yodeling friends at the World Health Organization. A report at World Net Daily says at least three of the WHO’s top flu “experts” have financial ties to vaccine makers.

That sure explains a lot.

Meanwhile, anyone who doubts that money is the real driving force behind swine flu fears only needs to check out Business Week magazine.

A recent headline there tells whole story by itself: “How Big Pharma Profits from Swine Flu.”

Careful there, Business Week. That kind of thinking would have gotten you branded a radical conspiracy theorist just a few months ago!

Just check out these big paydays off swine flu vaccine sales:
•  $1.7 billion for GlaxoSmithKline
•  $700 million for Novartis
•  $500 million for Sanofi-Aventis
Those figures are for the fourth quarter of 2009 alone — analysts expect them to grab similar piles of cash for the first quarter of 2010 as everyone from President Obama to Santa Claus push these needless vaccines on you and your children.

Business Week also notes that vaccine sales are booming just in time: Patents on prescription drugs worth a combined $135 billion in annual sales are about to expire… with no new meds ready to replace them.

And that means you can expect another phony swine flu scare any moment now.

Never feeding the flu fears”.

And tp://articles.mercola.com/sites/articles/archive/2010/01/02/Harvard-Takes-it-Back-and-Says-Swine-Flu-was-Oversold.aspx

These need to be read in tandem with the other vaccine sagas:

Martin Walker’s ongoing expose of  The Drug Industry-GMC-NHS  vendetta  against Dr  Andrew Wakefield  for daring to question the benefits of mass vaccination of infants;

about the risks versus benefit of vaccinating pubertal boys and girls against cervix cancer;

and the mad search for an HIV vaccine against a disease which is in fact a sociological problem of  nutritional immunodeficiency upon which is superimposed sexual violence as in rape  or voluntary recklessness usually against (usually)  innocent partners – promiscuity   in multiple concurrent sexual relationships as currently promoted  by sexual predators  like Tiger Woods and the illegitimate and corrupt  South African “president” Jacob Zuma. .

UPDATE 16 December:

It is now 15  weeks since this column  expressed grave doubt about the cost-benefit of the touted anti-virals Tamiflu and Relenza .

All hell has broken loose over drug company fraud- which could only have happened in collusion with big politicians:

while Bayer and BMS Bristol-Myer Squibb are under heavy attack, and Pfizer paid a record $2.3billion fine to settle, and Novartis and Baxter are under the vaccine fraud microscope,

not only has proven  swine flu  mercifully fallen far below pandemic deathrate and sickness predictions,  while big batches of vaccine (GSK)  have had to be pulled due to serious complications even in Canada- and GSK directors /promoters too are under scrutiny;

but predictions about the fraud of massive anti-influenza drug promotion have proven all too true.  The BMJ today is full of doubts since a solitary Japanese author questioned the veracity of selectively published let alone unpublished Tamiflu studies orchestrated by Roche.

As some say, in marketing and disease-mongering,  its like in love and war-  anything goes – and provided it promotes American corporate interests, the FDA goes along.. ..

20091111 A This WW1 Armistice day : A new report quotes the CDC projection that “4000 rather than 1200 Americans have died of swine flu since April.. and that the  University of Minnesota Center for Infectious Disease Research thinks deaths are likely to be in the 30,000-to-40,000 range, and would have a long way to go to even get there… The vaccine should also cut the death rate.”.

Yesterday an appeal from the FDA Commissioner of Food and Drugs went out to all to promote the swine flu vaccine. But Dr Hamburg does not quote one iota of evidence that the vaccine does or will do more good than harm- especially in those at highest risk, the pregnant, the  old and ill and infants. She fails to address the cardinal issue: why have no trials so far assessed the benefit of the vaccine (on swine flu infectivity and morbidity)  against placebo on a background of well-known anti-infective natural safe supplements?

It is perfectly obvious that with an apparent infectivity rate of swine flu well above 1:1000, but an apparent linked mortality rate of  2 per million of population per month through September-October- the USA- the FDA CDC and the other interlinked countries at highest risk- Canada, Australia,  UK, Brazil, Argentine –  had a duty to see that the vaccines were immediately tested in double-blind RCTs against placebo injection in volunteers–  at least the apparently moderate risk ie the well young, but most of all  in the high-risk groups ie the age extremes, pregnancy and those with serious chronic diseases.

From the already established  spread-, fatality- and complication rate, it is obvious that, during the current upsurge reported by these countries, it would take no more than a few weeks – at a vaccination rate even in Sweden of 2million people in a few weeks, with spread rate of thousands of new  tested cases a month, to produce the crucial answers- how far does the vaccine cut the infection rate, and  the morbidity rate and degree.

Yet according to the NIH Clinical trials.gov registry, there is still no such trial listed. The FDA decided it doesnt require efficacy data on the vaccines.

So it appears that the Authorities in all pandemic  countries are guilty of gross deception- at best  that they know that the vaccine is pretty useless, or worse, that they dont know – and don’t want to know till the vaccine is all used up. Dastardly conspiracy theorizing, by sober scientists,  but that’s what the Authorities’ declared deliberate omission (evasion of such a basic obvious  efficacy trial)  creates.

At least there is a double-blind placebo-controlled  clinical trial of Tamiflu in progress in Hong Kong, in 300 patients with the swine flu, lasting a year. . The outcome is likely to be that, if tamiflu doesnt prove to be worse than the placebo, 300 is far too few subjects to show any significant benefit over placebo.

Bloombergs reports today that Norway has had 6300 confirmed cases by last week and 16 related deaths by Nov 9, but while Sweden had cases doubling weekly to the last week of October, there have still been only 3 related deaths reported . However on Nov 9th perhaps the 4th related death was reported in Sweden.  . But Sweden has banned media reporting on swine flu vaccine deaths, which stood at 5 after 2million vaccinations.

It looks like the cumulative swine-flu related deathrate in Europe has reached 0.8 per million population.

20091109  The past week: only one new case has been reported in Southern Africa (Namibia) and no linked deaths in Africa; in Canada between 3-5 Nov there were 14 new linked deaths (14% increase);   in Netherlands 7 people died in the week to 6 Nov, with the total there still only around 20 attributed to the swine flu.

The USA latest  CDC report shows that in the 2 months   to end October influenza-associated death rate was  2 per million of population per month; for comparison, in 2006 the monthly deathrate  was 770 per million, of which influenza and pneumonia  contributed only 2.3%, the 8th  leading cause  after cardiac-, stroke, malignant, lower respiratory, accident, diabetes and alzheimer causes.  Since – accidents aside- all of these commonest fatal  diseases are precisely the highrisk patients that die most of influenza anyway,  it is unclear whether the present increase in ILS ( influenza-like syndrome)  deaths has significantly increased overall mortality

SWINE FLU 1918: There is a graphic  interview on November  5th with a living survivor of the 1918  genuine flu epidemic, which killed some 2.5-3% ie 25 000 of  every million  people   (5% in India) by blue death- drowning-  in at least America, France and Germany, far more in India.  That  H1N1 plague lasted at least 2 years,  infecting perhaps 1/3 of the world population of 1.5billion,  with 50% cross-infection  rate and mortality rate of between 2% and 20% of those infected.

SWINE FLU 1976:  that outbreak never spread beyond Fort Dix, where one victim died. But in the ensuing government panic, 22% of the population were given a hastily prepared vaccine, followed by 1098 cases of Guillaine-Barre syndrome, at least half of which were attributed to the H1N1 vaccine, with at least 25 deaths. A recent review puts this risk (of GBS after H1N1 vaccination) at about 1 in a million- far  higher than  there is now of  healthy people dying of the current swine flu outside the Americas and Australia.

SWINE FLU 2009: it is cold comfort to see the current swine flu  global picture on Wiki at the end of October- a true deathrate of probably <1 per million after at least 6 months. The big question is, will there be more waves of it or, worse, a deadlier mutation caused by hasty vaccination?

The biggest  question, mystery, now is:  if swine flu is indeed pandemic  and spreading at least in America and Australia, why are there still no placebo-controlled trials published confirming that the vaccines and antiviral drugs reduce infectivity, severity and mortality of the 2009 H1N1 virus?

INCIDENCE: While bigger countries have stopped testing all but key or high-risk suspect cases for swine flu,   the smaller countries’ figures of confirmed cases relative to population size are instructive:

closed communities like the Cook Islands, Hong Kong and Macau respectively found incidence of 0.9% – 0.47%;

but only 0.07 -0.25% in other “ islands” world wide – Caymans, New Zealand, Jersey, Bahrain, Iceland, Marshall, Australia, Malta.

Mainland countries that apparently continue screening all who report in with flu symptoms – like Portugal and Belgium -found respectively 0.24% and 0.08% of suspects positive for  swine flu.

FATALITY: As regards death rates: Mexico and South Africa reported apparently related deaths among confirmed swine flu cases as approx 0.7%/1000 infections ; Australia & Japan approx 0.5%; Hong Kong 0.12%; and Germany and Portugal approx 0.02%.

Multiplying  the incidence rate by the case  fatality rate- or more simply dividing the number of deaths by the population- suggests that if you the reader  are generally well, the odds of  your  dying of swine flu are far below  1 in a million; whereas infants, or the elderly,  the chronically ill or  the obese are at far higher risk of dying anyway.  So far there have been some 1500 deaths in 308million Americans recorded in people testing positive for swine flu- that, is some 5 deaths per million- but by epidemiological  reasoning by an  international team, most of those deaths were already in pregnant or  other (chronically) high risk patients  and therefore not attributable primarily  to the swine flu itself- they were already, knowingly or not, at high background risk..

1500 deaths in 6 months  in America is ~0.8 deaths  per million per month, but the  background- all-cause  death rate there averages about 68 per million per month by last CDC count.

Japan and India with the highest population density in the world for  big  developed populations are remarkable – since the first case in their spring 6 months ago,  similar  population deathrates so far  of only 0.00004%  or  0.4 per million.

whereas in USA the official attributed  swine flu death rate so far is  12 fold higher ie  about 0.0005% ie  5 per million. North America’s epidemic  had only a month headstart on the rest of the world.

These fatality rates may be the maximum theoretically, since even in these first-world countries, the great majority of those who did have swine flu symptoms would not have reported in to be tested.

While most cases of swine flu would have been unrecorded- shrugged off-  in both developed and poor countries it is likely that many deaths at the time of maximum scare may have been wrongly ascribed to swine flu. This is what the naysayers about deaths after vaccination (whether against eg HPV- cervix cancer or against swine flu) are arguing strongly- that with mass vaccination superimposed on normal deathrates, the deaths within a few hours of vaccination or within days of  flu  are simply co-incidence, they are unrelated to the co-incidental  vaccination or the flu….

In Canada, “The majority of suspect swine flu patients— over 85%  (in intensive care)    — have some associated medical risk factors.”

The current NICD  stats for South Africa show that 77% of those who died with swine flu had  relevant co-morbidity  – 50% had HIV, 28% were peripartum women, 21% were obese,  11% diabetic, and 9 to 11% had active TB and/or serious cardiac disease. 91deaths is 1.8deaths per million – surprisingly low in the most unequal and reckless population in the world with massive overweight and ischemic heart disease;   the poor  great  majority having  been  increasingly deprived of jobs, education and quality health care, and suffering the  highest AIDs, tuberculosis,  infantile and maternal  mortality rates,  due to criminally negligent government since ‘independence’ 15years ago which has left the majority increasingly worse off.

So while the 2009 swine flu infectivity  the world over  is  probably far above 1%,  the fatality rates  causally related to the flu virus in those who contracted the swine flu in developed prosperous northern  countries (eg Europe, USA, Canada, Japan) was surely well below 0.03% ie <3:10 000;   and in poor countries like RSA and Mexico and India, probably similar since the virus would have spread far more densely in crowded poor communities with  higher malnutrition and underlying common diseases- but more protected by  having already survived poverty-related infections but also having less robust immune response.

It remains a mystery of rational reasoning as to how the wildfire spread of the 2009 H1N1 virus, and the low linked case fatality rates,  justify the promotion by first-world countries of ‘pandemic’ panic and mass treatment  with untested vaccines  and risky antivirals- especially when the vaccines contain  notoriously risky adjuvants like mercury, aluminium and squalene, let alone extracts (and possibly prions)  from species other than humans. These countries seem to have learned nothing from experience the past century with influenza, polio and HIV.

The reasons may be simply economic- Only Disease Pays, it’s a huge boost for healthcare providers, and manufacturers of  “antiviral” drugs, test kits, anti-swine flu vaccines, masks, disinfectants etc.

Why are there such differences in reported swine flu deathrates in similar countries?

Examining regions in the ~  6 months since the the pandemic hit them:

EUROPE: the biggest nation- Germany with 80million people has had  20 000 people test positive ie 1 in 40 000, with 9 deaths  ie about 0.1 in a million of population.

AlpineSwitzerland with almost 8million people has tested all suspicious cases with only 1000 confirmed swine flu, and no suspected deaths – but it  has  banned the  Glaxo  vaccine Pandemrix from being used in  pregnant women, children or young adults (below 18 years of age) or elderly (above 60 years of age).

Scandanavia: In Sweden this Glaxo vaccine has already been associated with 5 deaths in the first 2 weeks  –  5 deaths per (2) million population vaccinated in a month   -with  only some 2000 flu cases documented. Yet   so far in 6 months  only 3 -4 deaths there – 0.3 -o.4 per million population-  have been associated with swine flu itself . If 5 deaths there  soon after the swine flu vaccine , out of (2) million people vaccinated in less than a month,  are co-incidental- a vaccine-related death rate of 1:200  000. – one can equally argue that 4 deaths with the swine flu in a month  in a population of 9.2 million is not a causal relationship but co-incidence of death from other causes and not from the passing mild swine flu.. Norway has had 15 deaths ie 3/million; but Finland only 0.4  and Denmark only 0.16 per million. These and Switzerland are all cold countries with some 33million total population, 22deaths representing a fatality rate of 0.66 per million- the same as the average for Europe. Can there be such significant difference in prosperity and social services accross the EU  to explain the vastly different death rates? Or is it just statistical vagary, or  the fault of sensationalist disease-mongering  media?

A warmer but still cool  country like Germany has a swine flu deathrate of only 0.1/million, whereas the warmer British Isles have a rate of 2.5/million. And the  four  Greko-Latin European nations vary from 0.5 in Portugal & Greece  to 1.1 in  Spain to 4/million in Italy. Why the 8 fold difference? they all  take plenty of wine, olive products and a Mediterranean diet; and many citizens travel widely between these old countries and their migrant kith and kin at  the fountainhead  of swine flu  in North America. .

The overall European swine flu deathrate is only 0.78/million, with France – stretching from the Alps to two warmer  major oceans – similar, and the Low Countries only  0.5..  Why deathrates in three prosperous countries  genetically so linked to the rest of Europe but climatically so  diverse as  Norway, Italy  and UK   are so much above the rest of Europe remains to be unraveled.

CONTINENTAL DIFFERENCES:  in poor  South America there are also wide differences with 1.5 / million in Argentine but 7 per million in Brazil and the whole continent,   compared to 3 per million in the colder  North America;  4/million in the warmer  Caribbean; and  9/million in Australasia.  Why should deathrates be the high  in the Americas and Australasia, but 90%  lower in Japan, India and most of Europe?

But presumably the bigger and poorer the population, the fewer swine flu deaths  get reported, tested and  attributed- this may apply equally in Southern Africa, as in India, China and Russia.

Despite the vastly different climate conditions under which the majority of their people lives, the American deathrate so far – 5/million- is 25% higher than in Canada and poor Mexico‘s 4/million. But the USA admits that most cases of virus-like pneumonia are no longer being tested for H1N1, there are assumed to be due to it. Yet some sources say that this assumption grossly overestimates the  actual swine flu.

COMPARISON WITH AIDS: while the flu also  knows no social barriers- it merely spreads faster and bites faster  in denser and more vulnerable  poor populations- AIDS remains largely a scourge of ignorance, violence (male) and recklessness(male)- especially amongst politicians, who are  amongst the most promiscuous people globally, but eg  in South Africa also the cruelest in deliberately depriving the population until very recently  of both a semblance of social security and antiretrovirals, while spending the abundance of tax revenue on corrupt profligacy – in unneeded weaponry, and personal luxuries like mansions and (to this day) German limos.

Hence the prevalence rate of AIDS varies from above  15% in Southern Africa ( antenatal HIV prevalence of 30%)  to between o.1 and 1% in the rest of the world; with mortality varying from 50% within a year  of clinical presentation in the malnourished squatter millions  without treatment, to 50% survival after 20years with decent living standard and ARVs etc. In South Africa this year AIDS is said to kill a thousand a day ie 20 per million of population every day ie 7200 per million (7.2% of the population) per year- against a crude birthrate of 2% giving a nett population decrease of 5.2% a year, reducing life expectancy at birth to only 49years .

THE VACCINE  SAGA: MORE DECEPTION WITH MISLEADING TRIAL RESULTS :

HIV-AIDS  VACCINE:  after >30years  there is still no proven safe  relevant vaccine in sight against the HIV.  But if rape and male reckless promiscuity  were stopped, there would be no need for a vaccine since cross-infection is so easily avoided.

SWINE FLU VACCINE: Since there has been  no  trial published of the clinical benefit of the  flu vaccine, no objective  information whatsoever is available to judge it’s efficacy versus risk  in  swine flu prevention.   No significant double-blind  trial has been done offering the flu vaccine versus placebo injection.  The first uncontrolled apparently open trial  started  in Australia 22 July, with results  promised and delivered within 6 weeks ie 2 months ago. It is strange indeed that just 8 weeks after the start of that trial, the Australian govt approved the vaccination campaign. . A medical media report of 11 Sept says only 240 people were enrolled in the trial, age 18 to 64 years ie outside the peak risk agegroups at the extremes of life; and the only result released was that the subjects had a good antibody response.

Even the NEJM official trial report gives no clinical results as to protection- although  the New York Times got it wrong in reporting that the “convincing  trial showed robust  protection” . This conclusion is hysterical nonsense since  the only data reported was the antibody response, which does not mean there will  necessarily be any clinical protection against the swine flu.  There can be  no conclusion  as to whether the vaccine reduced the swine flu infection rate or severity because there was no placebo group, double blind or otherwise. Similarly, the Australian trial in children 10 to 17 years old,  the Spanish trial in toddlers, the USA trial  in pregnancy,   and the Chinese trial, showed good antibody response by 10 days – but gave no result about clinical protection.

So all we need is a simple 2 x 2 RCT of  flu vaccine versus placebo vaccine, with all cases independently covered by eg a supplement of zinc plus  highdose vitamin betacarotene + C + D + K plus fish oil as baseline safety net,  or placebo. The most important question remains: given the huge proven benefit of  safe vigorous doses of these cheap freely available supplements against both flu and AIDS, do people need anything more than a multisupplement to reduce risk of all diseases?  and does adding a costly hazardous H1N1 vaccine on top of that give worthwhile better protection against swine flu? The answer must be overwhelmingly NO, given the risk of at least GBS if not anaphylactic death after H1N1 vaccines. Why take a vaccine if it’s risk is  far worse than that of the swine flu itself, let alone  simple all-system multinutrient prevention that reduces all-cause mortality by at least a third?

But the last thing that vaccine manufacturers,  marketeers and governments  want is a negative answer, so they dont allow such a trial- is it because they lack courage, or that they already know the answer is negative, or worst of all,  that the vaccine is worse than useless?

Some may argue that it is unethical to offer nothing ie double placebo in such an RCT with rare but arguably serious virus-related complications. So all could be covered by at least a simple standard multivite a day at below RDA levels- which by all accounts gives marginal if any benefits except in the malnourished.

Obviously the difficulty with such a virus trial  is cost and invasiveness:  in  an RCT of the vaccine, one ideally needs to have  both serological and culture screening for this hybrid H1N1 virus at baseline – as well as placebo-controlled evidence of reduction in disease. Since the swine flu is so far milder than seasonal flu, there is no other way of defining whether a specific swine flu  vaccine is of significant overall benefit against this H1N1 virus.

Trumpeting “pandemic” and compulsory vaccination with an unproven vaccine  is a great distraction and profiteering  for governments-  presidents and the Big Business that controls them and their agencies,   beset with insoluble political and corruption scandals as are most. Recently an Australian anti-vaccination group published a damning cross-referenced  litany of evidence against  the trillion$ vaccination industry.

The current “pandemic” distraction with swine flu while they wage war on their peoples, effective martial law implemented or foreseen  in the USA, China,  and South Africa (predicted conversion of the police to a massive politicized  paramilitary, nationalization of all major industry and business and provincial governments), is beyond the imagination of most fiction writers except masters like Margaret Atwood – ‘The Handmaid’s Tale’;  Jose Saramago – ‘Blindness’ and ‘Seeing’;  Gabriel Garcia Marquez ; Franz Kafka.  .

We can only continue to pray, hope that sanity will prevail , that  RCTs  of  both the swine flu vaccine and antiviral drugs are  being done  to prove that they are both useful, necessary and safe. There is no evidence on the internet of this,   suggesting that conspiracy theory may  prove correct – that the whole vaccination and antiviral drugs if not the severity of the ‘pandemic’  are simply the result of disease-mongering for profit, like ever-popular  war-mongering on every continent..

THE 2014 VIRUS SEASON DAWNS: URGENT UPDATE: AVOIDING THE SEMMELWEIS REFLEX; natural antibiotics- Vitamins C & D3 – avoiding vitamin denialism.

update 22/3/2014the March equinox:Vaccines and antivirals for preventing   and  treating  influenza in healthy adults have  very modest benefit.  as  the seasonal flu epidemic wanes in the northern hemisphere and approaches in the south, Authorities eg the US CDC  continue relentlessly to promote mass flu vaccination. The South African Authority NICD recommends vaccination for anyone at high risk ie the elderly, infants or the sick, and carers. It also recommends antivirals eg Tamiflu for infection- but the BMJ recently publishes  Study claiming Tamiflu saved lives was based on “flawed” analysis. a 2012 BMJ  report by the samemedical journalist   Zosia Kmietowicz   notes Cochrane group rejects Roche’s offer of “advisory board” to discuss analysis of oseltamivir data. The 2011 Cochrane question remains unresolved:  Does Oseltamivir Tamiflu  Really Reduce Complications of Influenza?

But current Cochrane review of controlled trial publications to 2013 confirms  Vaccination of pregnant women is recommended internationally, while healthy adults are targeted in North America. The overall efficacy of inactivated vaccines in preventing confirmed influenza has a NNV of 71 (95% CI 64 to 80). . Live aerosol vaccines have an overall effectiveness corresponding to a NNV 46 (95% CI 29 to 115). Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates. Inactivated vaccines caused local harms CONCLUSIONS: Influenza vaccines have a very modest effect in reducing influenza symptoms and working days lost in the general population, including pregnant women.  This review includes 90 studies, 24 of which (26.7%) were funded totally or partially by industry. Out of the 48 RCTs, 17 were industry-funded (35.4%).

A current German review  Methodological quality of systematic reviews on influenza vaccination.   Fourty-six systematic reviews fulfilled the inclusion criteria. Average methodological quality was high  but variability was large (AMSTAR range: 0-11). Quality did not differ significantly according to vaccination target group. Cochrane reviews had higher methodological quality than non-Cochrane reviews (p=0.001).  this was due to better study selection and data extraction, inclusion of unpublished studies, and better reporting of study characteristics (all p<0.05).

20/1/2014   Protecting us from the new year northern hemisphere viruses:   natural antibiotics- Vitamins C & D: avoiding vitamin denialism as cause of more deaths.

Abstract: The Semmelweis  Reflex is about rejecting, deriding important new scientific discoveries or any serious sincere statement/action.    I didnt  fully appreciate the importance of that  age-old human  (mostly male) evil – mocking, martyrdom  and murder by denialism-  until I started this review of the current flu season threat and the role of supplements, and researched  pioneer medical martyrs Drs Ignaz Semmelweis, Jack Drummond  and Linus Pauling  as  paradigms of the scourge of modern vested-interest denialism and falsehoods, in medicine as much as politics, religion etc..

In fact,  just as it is negligence to deny (as Semmelweis’s persecutors did) gloving up or  properly washing  hands between examining patients , or ensure that every adult has bloodpressure checked occasionally, it is clearly bad practice  not to ensure that everyone – especially the young and old,  takes a multinutrient plus extra vigorous dose vitamins D3 and C, plus some protective herbs- garlic, cinnamon, ginger, origanum; and fish oil and/or coconut oil if not both; and drastically cut down sweetness intake- especially fructose, sucrose  and aspartame that now pervade all mass- produced food and drinks..

update 21 January 2014 : URGENT: THE 2014 FLU EPIDEMIC:     “High H1N1 prevalence and mortality rates a concern:    Type A (H1N1) influenza, the  commonest flu virus in Canada this year, has a higher  than anticipated mortality rate  causing some to wonder if it’s virulence has increased.             The worrisome factor  “is the reported mortality rate,” says  McGill University. As of Jan. 13, there were twenty confirmed deaths in Canada   attributed to H1N1. “There are more deaths than what we expect for the regular H1N1 influenza, The strain this year could be more virulent . 96% of this year’s lab -confirmed influenza is H1N1. The virus is unusual in that it appears to affect younger people more than other strains of seasonal influenza. People  20 to 65 are being hit harder than usual, comprising 52% of flu cases.                                  However, if you look at Europe,  it’s still H3N2. Its an example of how   you never know what the flu is going to do.”           Alberta confirmed a death  on Jan. 8, due to the virus H5N1, an avian virus. The  deceased woman had recently returned from China. The mortality rate is higher with H5N1 than H1N1, “but fortunately, it’s not an easy virus to transmit”. So far, it seems that there are no cases of H5N1 transmission from human-to-human. It seems   like the cases of H5N1 are few and far between and related to contact with birds in  China.     Patrick Janukavicius, Montréal, Quebec.  In the same period, at least 20 children have reportedly died of the same strain in USA.

update 12 Jan 2014  THE ANTIFLU VACCINE DECEPTION: this review by Doc Joe Mercola     stresses the disease-mongering myths,  futility and risks in real life of flu vaccination  and antiflu drugs eg Tamiflu ; and the overwhelming importance of natural immune boosters like Vit D3 & C, zinc, selenium,  herbs, and hygienic prevention.

1 Jan 2014  CURRENT INFLUENZA STATUSThe  22 December  solstice is the sun at its southern nadir seen from planet Earth, the onset respectively of real winter in the Northern hemisphere, and real summer in South Africa. Last year   the Gregorian New Year heralded a fierce flu season in the northern hemisphere, and as usual feathered- and jet-propelled  air travel brought the corresponding surge at the bottom of Africa.

And ominously, the Plagues & Pandemics   (Howard Phillips 2012) of temperate climates  that did so much historically  to mould global demography not least  the past 360 years in South Africa ( –STDS- pox, bubonic, polio, cholera, influenza, and now  tuberculosis, Mad Cow disease, and   HIV-AIDS). and especially antibiotic-resistant germs – are all on the increase despite (or because of) the increasingly futile $trillion armamentarium of 20th century designer vaccines and other antimicrobials.. 

Pneumonia is a welcome   friend of the old, often rapidly relieving prolonged degenerative incapacity;  such ending mostly by virus respiratory infection  the gateway for the  final bacterial infection.  

Unlike the  selflimited coronavirus common cold, breath-and hand-borne type A  influenza, although usually mild in the well,  is the commonest trigger in the frail.  Many  of us in our (grand)parents’ time lost relatives in the 1918/1919 “Spanish”  H1N1  flu pandemic. But that was a unique  global catastrophe because it killed mostly  armies  of healthy men, and then  young working adults, apparently from cytokine storm, with 30 % of the workforce out for up to3 weeks if not  20% mortality.  This is harrowingly described in the recently published   Letters ( to his Mother) of Dr Arthur Conan Doyle, who lost – apart from his first wife to TB- more young relatives to the  flu  than to warfare.

The recent spring  months here – apart from seasonal allergies -have seen declining viral respiratory illness in Cape Town, with the  upper respiratory accent often shifted down to more gastritis-enteritis .

But New Year 2014   UK and northern North America forecast  and are having a  wet if not white New Year.  ‘Flu rates are reported already high  and rising  in USA and Canadamostly influenza A H1N1(swine-avian flu-the main 1918/19 killer); including already 6 deaths in USA and 3 in Canada.

but not in Europe, where  the influenza (A > B) prevalence is still low and slightly more H3N2 than H1N1;  in UK there has rather been been increase in RSV respiratory syncytial virus bronchitis in infants. .  .

In fact by 28 December the exploding H1N1 deathtoll had hit 13 in Texas alone; especially in youths; with increasing Tamiflu resistance reported eg in Missisippi.. On 24 Dec the USA CDC mailed an emergency Advisory Notice to Clinicians: Early Reports of pH1N1-Associated Illnesses for the 2013-14 Influenza Season: From November through December 2013, CDC has received a number of reports of severe respiratory illness among young and middle-aged adults, many of whom were infected with influenza A pH1N1 pdm09 virus. Multiple pH1N1-associated hospitalizations, including many requiring intensive care unit (ICU) admission, and some fatalities have been reported.  While it is not possible to predict which influenza viruses will predominate during the entire 2013-14 influenza season, pH1N1 has been the predominant circulating virus so far. For the 2013-14 season, if pH1N1 virus continues to circulate widely, illness that disproportionately affects young and middle-aged adults may occur. 

Our  regional  South African Communicable Diseases Institute says H1N1 was documented here from April to September. But of 2566 pts with severe respiratory illness for January to October 2013 enrolled and tested at the five sentinel sites, only 6% were positive for influenza – mostly virus -H1N1. A pneumonia case in Cape Town was found to be due to Leigionnaire’s.

Now from China 147 human cases of avian influenza H7N9 have been confirmed including 48 deaths. – especially from poultry contact. No vaccine is currently available for avian influenza (H7N9) virus.

SAPA–AFP, 10 December 2013:  Resistant flu virus keeps contagiousness.  A mutant form of the H7N9 flu virus that is resistant to frontline drugs is just as contagious as its non-resistant counterpart, according to a study, published inthe journal Nature Communications.  The virus has claimed dozens of  lives since its outbreak in February. H7N9 is believed to have spread to humans from poultry, where it circulates naturally. The World Health Organisation (WHO) said on its website that “so far”, no evidence has emerged of  “sustained” transmission of H7N9 among people.

And H7N1 and H7N7 has broken out in ostriches in South Africa,

So never mind the  common cold  coronaviruses and many other prevalent infections, increased caution is due against all common diseases at this season- both the USA H1N1 swine flu circulating the past few years,  and now the Chinese H7N9 flu. . And the MERS-Co Virus Middle-East SARS-type outbreak has not gone away… 9 new cases reported the past week or two  from the KSA alone .the-deadly-middle-east-coronavirus-outbreak/

A  current NEJM  has a new report of a trial of quadrivalent Vaccine for Prevention of Mild and Moderate-to-Severe Influenza in Children by vaccine manufacturers GSK. The vaccine reduced severity by perhaps 70%- but at a cost of 1.5% serious adverse events, 50% more than the control group (hepatitis A vaccine only).                                                                                    The question remains- why risk  flu vaccine’s ~1.5% serious adverse events when a single high dose of vitamin D3  300 000iu  even just annually, and regular vitamin C with a multivite  including zinc and selenium (at trivial cost ) largely cover one  against a multitude of infections including AIDS and TB, and all degenerative health   problems?

PRECAUTIONS:

Is it coincidence, or divine evolution, that we have had available at low cost  for about 60 year (never mind zinc,  selenium, iron, iodine, vitamins A and vitamin E) two safe natural major antimicrobials in vigorous safe dose   –  vitamins  C and D3?  Medico-Pharma Big Business and governments have been heavily discrediting and ruthlessly suppressing these  for their own profiteering vested interest  even as plagues of HIV, TB,  influenza rage, and Big Business determinedly profits hugely from killer  smoking and alcohol sales despite increasing  marketing restriction?   South Africa- a major producer of alcohol and tobacco-smoke, and fossil-fuel-burning power stations, factories and motorvehicles – continues to lead the world with  the highest road and respiratory death rates  despite zealous attempts to reduce their lethal  use.

Apart from optimal hygiene including  avoiding livestock  and poultry contact, smoking, alcoholism and pollution including  swimming and sick buildings- air-conditioning-           what can we take  to minimize avoidable influenza  ie immune depletion risk? apart from enough  sunshine, exercise, rest, sleep, walking barefoot, not carrying a cellphone,   and good mixed fresh organic diet? The clinical benefit of influenza vaccines is anything but proven, and the adverse risks appreciable.

Big Business and thus governments  and the media  profit from illness, so they keep publishing articles promoting Big Business: new antibiotics, vaccines  and other synthetic drugs that do not prevent or cure but if anything perpetuate chronic degenerative obesity-diabetes-vascular-respiratory,- digestive-arthritic-cancer diseases; – and  GMO-genetically modified preserved  food  and bottled drinks stuffed with slow poisons like refined cornstarch – fructose; salt; sucrose and cereals, soya,  Roundup, antibiotics, preservatives, estrogenics,  aspartame,  and especially boiled and baked omega6 and sugars;  instead of marine omega3 and MCT- medium chain triglyceride virgin coconut oil, and unrefined cereals eg oats, wholewheat bread etc..  

Big Business and it’s cash-cow  Disease Industry decries  the natural healthgiving lowsugar Asian/ Mediterranean  diet-organically pastured and grown livestock meat and dairy products, lightly cooked if not raw (oily)  fish,  fruit and nuts, coloured veggies,  and plenty of  oils in their natural plant form. These were  the norm till food processing became Big Business in our lifetime post WW2, and the developed world was bluffed by Organized Medicine, the Food Barons and Big Pharma  with the masterly fiction of Ancel Keyes, into jettisoning the natural longevity “sea and farm” diet of the east eg Japan, and West eg Mediterranean (fresh produce & cholesterol-rich dairyproducts, meat and fish)  for the Diet Deception (Gary Taubes, Tim Noakes) and Bad Pharma ( James le Fanu, Ben Goldacre) of Ancel Keyes‘  low-fat high-refined cereals, margarine; and  the cholesterol -busting and psychotropes/ painkillers /antidementia/antivascular/ antidiabetic disease Designer Drugs-for-all  myths.

It spends multimillions promoting alcohol,  smoking and ever-newer designer prescription drugs and vaccine, and  disinformation on old well-proven cheap drugs like  reserpine, amilozide, metformin,  natural physiological  human hormone replacement,  natural antioxidants and anti-inflammatories ,  and decrying  ineffective but deliberately lowdose and isolated or imbalanced  vitamins and minerals .

The ATBC vits A+E trial  (isolated highdose vits A and E) was  one such  farce in very high risk smokers in an icy climate. . Others have been the recent Norwegian trial using only up to 1000iu vit D supplement a day,

and the current Annals Int Medicine editorial  review of three new articles condemning multisupplements: , on which Mike Howard publishes a scathing critique

*a commercial multisupplement in the TACT  post-heart attack trial – but the composition of the multisupplement  included only deficiency-disease prevention microdoses of micronutrients including 100iu vitamin D3/d and equally negligible vitamin K-  not pharmacological doses of key vitamins eg vits B, C, D & K2 that are well proven to greatly reduce infections and chronic degenerative diseases ;

* the  Physicians’ Health Study  randomized elderly professional men  to placebo or combinations of vitamin C (500 mg synthetic ascorbic acid), vitamin E (400 IU of synthetic alpha-tocopherol), beta-carotene (50 mg Lurotin), and a multivitamin (Centrum Silver – this included  anti-deficiency disease low dose of all common vits and minerals BUT   only 400iu Vit D3),   .

* The third study- on lowdose (traditional anti-deficiency disease) Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer was simply a literature review of 26 best-quality  published trials of microdoses – not pharmacological safe macrodoses.

ie these  three trials published in this  Annals Internal Medicine issue to please Big Pharma advertisors to discredit supplements shared the usual problem of now well-known futile lowdose supplement doses  at least of vitamins D3 and K, if not also vitamin C in the multigram dose scientifically promoted by the Drs  Stone- Klenner-Pauling followers.

Sir Jack Cecil  Drummond (1891-1952) was one of the world’s pioneer 20th century  biochemists and nutritionists in UK,  from  1916- 1952 discovering or defining  and promoting  under his world-famous biochemist professors Rosenheim, Halliburton and Funk the role especially  of vits A, B, C  and E. Thanks to his and Churchill’s forceful vision and foresight, he oversaw  food supply and diet  and thus keeping Britons healthy through and after WW2. He was  so successful in promoting healthy cheap and unpatentable micronutrients and natural fresh food  (in the face of the mushrooming megaprofit  processed food  and designer drug industry) that it  speculatively led to his and his family’s  1952 assassination by competing interests  in France The Vitamin Murders, Fergusson 2007. .

        MURDER BY DENIALISM: It is incontrovertible   common cause that irrational and often jealous medical denialism costs endless lives:
* Scurvy prevention:  Dr James Lind (who did the first ever recorded clinical trial) showed by 1750 that sailors’ scurvy on long sea voyages  was preventable; but  despite his pioneer discovery, the British navy cost the lives of thousands more seamen from scurvy when the Admirals  neglected for 50years until the Napoleonic Wars to supply the fresh produce-  eg limes – that rapidly cured and prevented the lethal scourge.

This despite the fact that another UK navy surgeon Dr John Woodall had already over 130 years earlier- by 1617 – published in UK  The Surgeon’s Mate stating We have in our owne country here many excellent remedies generally knowne,- Scurvy-grasse, Horse-Reddish roots, Nasturtia Aquatica, Wormwood, Sorrell, and many other good meanes… to the cure of those at home…and Sea-men returned from farre who by the only natural disposition of the fresh aire and amendment of diet, nature herselfe in effect doth the Cure (of scurvy- for which antiscorbutic citrus had been known since antiquity) without other helps. the Lemmons, Limes, Tamarinds, Oranges, and other choice of good helps in the Indies… do farre exceed any that can be carried tither from England.

* Childbed fever prevention:  in 1865  Dr Ignaz Semmelweis (1818 -’65) an AustroHungarian Roman Catholic ob-gyne in Vienna, was locked up, and beaten to death  within weeks, because he showed – to the outrage of his peers- that handwashing with chlorinated lime eradicated the epidmic puerperal fever (three times that in the midwives’ ward)  in  the  doctors’ labour wards; 70years before Thir Reich terrorists took charge, his senior colleagues reacted violently to his progressive promotion of (what was already more advanced British and  French) hygiene and science, and his urging them to wash their hands after examining corpses before examining women in labour..  .  Tragically for Semmelweis and new mothers in the Hapsburg empire then,  Pasteur (b 1822) and Lister (b 1827) ‘s germ antiseptic discoveries  were already being implemented further west, but  had not yet been publicized.

    *metformin after centuries of use as an antidiabetic herb galega officinalis,  and its extraction as an antidiabetic in 1922, came into increasing use globally from the 1950s as the best treatment for type 2 diabetes, but the USA- to protect their own new patent antidiabetic  drugs – ruthlessly suppressed  its use there (like that of the natural salt lithium for manic depression)  for 40years till the mid-1990s.

     *AIDS and ART denialism: until  5 years  ago in South Africa   the  overwhelming-majority “people’s”  government  (with the country’s vast resources),  and its successive  “health”  ministers,   cost the lives of an estimated 300 000  AIDS victims through sufferers  – indigent state dependents-  being denied  antiretroviral ART  drugs, (never mind still till now denied quality education and civil  security,  and thus    adequate basic nutrition, and meaningful housing,  jobs and thus hope.)  Genocidal AIDS denialism about which the still-ruling (since 1994) leadership cadre did nothing until under  intense  international pressure and repeated Constitutional Court orders, combined with political rival factioneering in the ruling party,   they  ousted the denialist president and his denialist Disease Minister in 2008.

DENIALISM TARGETS IN NUTRITION: 

VIGOROUS VITAMIN C ASCORBIC ACID  PHARMACOTHERAPY : Much effort and Big Pharma money  has been  spent to denigrate the irrefutable science-based work   (between their advocacy years shown) of Drs Irvine Stone (1934-1984), Fred Klenner(1948-74) and Linus Pauling (1970-1991) of  antibiotic dose >50 to 1000 mg/kg/d pure vitamin C (not the antiscurvy  10mg/d)  – as a universally needed essential in primates. We primats,  like guineapigs and a few birds and fish species,  are among the few  that do not make their own since we  lost the needed gene and thus enzyme in our evolution..

It took about 150 years after Lind’s publication for the antiscorbutic factor to be named as vitamin C by Dr Jack Drummond, another 10 years for it to be assayed and its structure proven- but despite the pioneering clinical work of Dr Fred Klenner in the 1950s proving the lifesaving benefit of tens of grams a day intravenously, it took another 20 years before Dr Linus Pauling  took up Dr Irvine Stone’s conviction and put highdose vitamin C  on the world Nobel prize map; just on Pubmed,  vitamin C has >51 000 citations  since 1921, and intravenously in 763 entries  since 1946, with  Dr Fred  Klenner reporting  it intravenously  asmajor antibiotic in the Southern Medical journal from 1948..

The 2009 book  Injectable Vitamin C and the Treatment of Viral and Other Diseases collection  of  medical journal papers from the 1930s to 2006 details the exhaustive scientific evidence proving the uniform benefit of even 1gm a day vit C both as an antimicrobial antiinflammatory antioxidant  and immunomodulator against major crippling / lethal diseases from polio to tuberculosis, pneumonia, hepatitis, rabies, encephalitis, neuritis, poisoning, cancer, and pancreatitis;                                                                                   

          and the persistent resistance of the FDA and other multinational Regulators to recognize (so as to protect their domestic patent drug manufacturers- Big Pharma and their politician and civil service lobbyists )- such uniquely safe and effective natural drug therapy.         The final chapters of that 2009 book pose the crucial questions of overwhelming vested interest by the organized medical – hospital –pharmaceutical mega-industry and governments in not eradicating preventable disease, the Big Pharma banning of natural effective remedies-  The Origin of the 42-Year Stonewall of Vitamin C, and Medical Resistance to Innovation,

The  University of Oregon,  the  Riordan-Gonzalez group and more recently Hemila and Chaker‘ and Ullah et al’ s 2012 reviews have  published much  validating what Drs Goodall, Lind, Drummond, Stone, Klenner, Pauling and Cameron started.

VIGOROUS   VITAMIN D3 CHOLECALCIFEROLPHARMACOTHERAPY  costing wholesale ~ <US$0.5/month for ~200 000iu /month  in South Africa)  reduces serious infection by perhaps 90% ie 9fold: . eg 80iu/kg/d – 500iu/d (15000u/month) for an infant, 50 000iu/wk or 200 000iu/mo for an adult; who if obese, may need two  to three times the average dose, to achieve the (?) optimal 25OH vit D level of around 70ng/ml for health, higher for any acute or chronic chronic illness.

The modern prophets of vitamin D3 have been the three pre-WW2 doyens :

Prof Chris E Nordin (MB ChB 1950) working in bone physiology for 60 years now; 84 papers on vitamin D on Pubmed 

Prof Walter Stumpf (1927-2012; MD 1952) the recently deceased  professor at North Carolina University, neuropsychiatrist and radiobiologist  in his 60year medical career with over 500 publications (76 on Vit D on Pubmed) including early discovering that vitamin D targets all systems and diseases; professor-walter-e-stumpf-ahead-of-his-time/ and https://healthspanlife.wordpress.com/tag/stumpf-dr-walter/

paralled by Prof Robert Heaney (MD 1951) at Creighton University, osteoporosis and nutrition authority with 119 vitamin D papers on Pubmed since 1982, over 400 publications to date;

succeeded by Prof Mike Holick (PhD 1971, MD 1976) with 391 publications on vitamin D since 1970 on Pubmed, who has done more than most to show that the maximum daily body production of vitamin D3 with plenty of sunlight is enough to prevent rickets and reduce all disease, but nowhere near the pharmacologically therapeutic 80iu/kg/d needed to maintain a vigorous all-disease protective bloodlevel of 60-100ng/ml.

and Dr John Cannell (MD 1976, registered psychiatrist from 1993, nutritionalist), a  legendary whistleblower .   who successively campaigned against  #cigarette smoking; and  uncovered:   # the cigarette-smoking  (Black Lung) compensationitis fraud of miners’ pneumoconiosis;          #the fictitious inflated “above national average” school results (Lake Woebegone)  that all states were inventing and  reporting (as is still happening – mass government deception- in South Africa) ;  then the  
# recovered memory therapy (RMT) scandal – a form of psychotherapy in which patients recovered memories of abuse that they had no previous memory of. Such therapy resulted in false memory syndrome (FMS) of events that never occurred as well as an epidemic of multiple personality disorder (MPD), a rare disorder historically conceived of as being a hysterical disorder.  Unfortunately, many MPD patients believed the psychiatrist conducting the RMT and went home to falsely accuse their parents and others of horrendous acts that never occurred. Cannell teamed up with two Harvard professors to write a peer reviewed paper on RMT, debunking the witch-hunt;                                                                               then since the 1990s researching and promoting  # vitamin D deficiency as major cause of much psychopathology including autism, and vigorous vitamin D therapy to correct multiple diseases, through the Vitamin D Council. He has (co)authored some 13 papers, and published a book. .

Now a major longterm German Cancer Research screening program has just publishd   the 2002-2013 ESTHER study (Perna ea) of 10 000 citizens followed with serial 25OH vit D  levels; to assess the association of apparently unsupplemented vit D levels with fatal and nonfatal CVD in the same study population.  Follow-up data, including survival status, up to over 9  years. Comparing subjects with 25(OH)D levels below 12ng/ml and above 20ng/ml resulted in the lower vitamin D level cohort showing a higher hazard ratio of 1.27 (95% confidence interval = 1.05-1.54) for total CVD and 1.62 (1.07-2.48) for fatal CVD in a model adjusted for important potential confounders. No significant association for nonfatal CVD was observed. In dose-response analysis, we observed an increased cardiovascular risk at 25(OH)D levels below 30ng/ml. Results for CHD and stroke were comparable to the results obtained for the composite outcome CVD. Our results support evidence that low 25(OH)D levels are associated with moderately increased risk of CVD, BUT  the observed association is much stronger for fatal than for nonfatal events.

But the benefit of sunlight in healing tuberculosis has been used for well over a century; while the Google antibiotic benefit of calciferol on Pubmed goes back at least to 1950.

In a prospective 16 mo trial in press from Australia, vit D3 even just 60 000iu/month (ie 2000iu/day) halved antibiotic use in seniors.  (Tran, Neale  ea 2014) Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial.

Since the toxic dose of vitamin D long term  reportedly may be as high as 600 000iu/day or a blood level well >150ng/l , imagine how much better the antimicrobial benefit of vitamin D3 at 80 to 100iu/kg/day or pro rata – even higher eg 10 000+iu/day for obese people who sequester more vit D in fat. .

Dr Robert F  Cathcart wrote 30 to 20 years ago in  Med Hypotheses. 1981 Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy   The amount of oral ascorbic acid tolerated by a patient without producing diarrhea increase somewhat proportionately to the stress or toxicity of his disease. Bowel tolerance doses of ascorbic acid ameliorate the acute symptoms of many diseases. Lesser doses often have little effect on acute symptoms but assist the body in handling the stress of disease and may reduce the morbidity of the disease. However, if doses of ascorbate are not provided to satisfy this potential draw on the nutrient, first local tissues involved in the disease, then the blood, and then the body in general becomes deplete of ascorbate (Anascorbinemia and Acute Induced Scurvy). The patient is thereby put at risk for complications of metabolic processes known to be dependent upon ascorbate.                     1984 Vitamin C in the treatment of acquired immune deficiency syndrome (AIDS). evidence is that massive doses of ascorbate (50-200 grams per 24 hours) suppress the symptoms of the disease and can markedly reduce secondary infections. In combination with usual treatments for the secondary infections, large doses of ascorbate will often produce a clinical remission which shows every evidence of being prolonged if treatment is continued. .. despite continuing laboratory evidence of helper T-cell suppression. There may be a complete or partial destruction of the helper T-cells during an initial infection that does not necessitate a continuing toxicity from some source to maintain a permanent or prolonged helper T-cell suppression. However, it is possible ascorbate may prevent that destruction if used adequately during that prodrome period. Emphasis is put on the recognition and treatment of the frequent intestinal parasites. Food and chemical sensitivities occur frequently in the AID syndrome and may aggravate symptoms considered to be part of the AID syndrome. A topical C-paste has been found very effective in the treatment of herpes simplex and, to a lesser extent, in the treatment of some Kaposi’s lesions.  Increasingly, clinical research on other methods of treating AIDS is being “contaminated” by patients taking ascorbate.                                                     1991 A unique function for Vitamin C is as reducing substance,  electron donor. When vitamin C donates its two high-energy electrons to scavenge free radicals, much of the resulting dehydroascorbate is re-reduced to vitamin C and therefore used repeatedly. Conventional wisdom is correct in that only small amounts of vitamin C are necessary for this function because of its repeated use. The point missed is that the limiting part in nonenzymatic free radical scavenging is the rate at which extra high-energy electrons are provided through NADH to re-reduce the vitamin C and other free radical scavengers. When ill, free radicals are formed at a rate faster than the high-energy electrons are made available. Doses of vitamin C as large as 1-10 g per 24 h do only limited good. However, when ascorbate is used in massive amounts, such as 30-200+ g per 24 h, these amounts directly provide the electrons necessary to quench the free radicals of almost any inflammation, and reduces NAD(P)H and therefore  provide the high-energy electrons necessary to reduce the molecular oxygen used in the respiratory burst of phagocytes. In these functions, the ascorbate part is mostly wasted but the necessary high-energy electrons are provided in large amounts.

A recent review from Atlanta Kearns ea found 30 papers which aggregate to show that annual vitamin   D3 dose (not D2) of  optimally 300 000 to 500 000iu (wholesale cost ~R5 in South Africa)  for deficient adults is best for avoiding poor patient compliance with minimal risk and major benefit.

THE INFERIORITY OF VITAMIN D2 SUPPLEMENT: It should be noted that the long-used Lennon’s Strong Calciferol datasheet  (1974 updated 2004) does not indicate that this 50 000iu tablet labelled ‘calciferol’  is in fact vitamin D2 (ergocalciferol), not the fourfold more potent cholecalciferol D3 formed by sunlight in the skin. This is disclosed only on the Lennons website.. and in the South African Medicines Formulary.  So ‘Strong Calciferol’ in South Africa (actually  the D2 not D3 form of calciferol) is convenient but seriously deceptive mislabeling-  much weaker than the ideal vitamin D3, and therefore its effect unpredictable compared to D3- in fact Dierkes ea Norway show that  giving D2 may actually lower 25OH vit D level in the blood..   Sadly, despite this being reported to the local manufacturers and authorities, no correction of the clinically serious misperception created by the Strong Calciferol label and insert has been issued  to health practitioners by the Medicines Control Council and the manufacturer Aspen-Lennons. 

A recent 8yr study in Cape Town blacks   Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in South Africa Martineau, Nhamoyebonde ,Wilkinson ea   confirmed that vitamin D deficiency (serum 25(OH)D <20 mg/L) is associated with susceptibility to tuberculosis (TB) in HIV-uninfected people in Cape Town as it is Europe. Vitamin D deficiency was present in 62.7% of 370 participants and was associated (OR ~5.4)  with active TB in both HIV-uninfected  and HIV-infected -(P < 0.001) people. Vitamin D status varied according to season:  25(OH)D concentration was double in summer-January- March compared to winter (23 vs 12ng/l; P < 0.001). Reciprocal seasonal variation in TB notifications was observed:lowest in autumn  and highest in spring October through December (4,2 vs. 5; P < 0.001). Vitamin D deficiency is highly prevalent among black Africans in Cape Town and is associated with susceptibility to active TB both in the presence and absence of HIV infection.

Antimicrobial implications of vitamin D is detailed by Youssef,  Peiris ea (USA  Dermato-Endocrinol  2011)   against all microorganisms – viruses, fungi, bacteria, protozoa  (except perhaps leishmaniasis)  as both profound prevention and therapy; in many cases without commercially invented marketed antimicrobials to which there is growing and deadly  microbial resistance, let alone toxicity.. There is evidence that seasonal vitamin D deficiency  status contributed greatly to the 1918/19 flu-pneumonia pandemic (Grant & Giovannucci 2009).

and finally, a month ago JAMA published from Marianna  Baum,  Richard Marlink ea the universities of Miami, Harvard and Florida  Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic  Antiretroviral-Naive HIV-Infected Adults in Botswana A Randomized Clinical Trial,  that Micronutrient deficiencies occur early in human immunodeficiency virus (HIV) infection, and supplementation with micronutrients may be beneficial; however, its effectiveness has not been investigated early in HIV disease among adults who are antiretroviral therapy (ART) naive.  2 year supplementation with either daily vitamins BCo,  C and E, selenium alone, or B,C,E with selenium vs placebo: study  conducted in 878 patients infected with HIV subtype C with a CD4 cell count greater than 350/μL who were not receiving ART between  2005 and July 2009.  Results  participants receiving the combined supplement of vitamins plus selenium vs placebo had half the  risk of reaching CD4 cell count 250/μL or less (adjusted hazard ratio [HR], 0.46); and secondary events of combined outcomes for disease progression  or AIDS-related death, whichever occurred earlier [adjusted HR, 0.56); . There was no effect of supplementation on HIV viral load. Multivitamins alone and selenium supplementation alone were not statistically different from placebo for any end point. Reported adverse events were adjudicated  unlikely  related to the intervention, and there were no notable differences in incidence of HIV-related and health-related events among study groups.Conclusions and Relevance  In ART-naive HIV-infected adults, 24-month supplementation with a single supplement containing vitamins BCo,C,E and selenium was safe and significantly reduced the risk of immune decline and morbidity. Micronutrient supplementation may be effective when started in the early stages of HIV disease.

THE PARADOX OF THE GLUCOSE- ASCORBIC ACID- CHOLESTEROL- STEROID CASCADE:              Is it coincidence, or  evolution, that the basic animal fast-energy circulating anabolic substrates are glucose, fatty acids and aminoacids?   from which basic glucose C6H12O6 ( from ingested  fructose C6H12O6 and sucrose C12H22O11, or fats or protein)  the liver manufactures the basic cardinal steroid  cholesterol C27H46O.     Then from cholesterol we metabolize by adding or splitting off carbon molecules  the crucial anabolic and regulating  human hormones-                                                                                                                    1. ouabain C29H44O12  the  adrenal hormone  made also  in the hypothalamus and heart ; adrenal),                                                                                                                                           2.  active calciferol C27H44O the strengthening and reproductive secosteroid;                                                                                                                                   3 the prime sex/ reproductive steroids  pregnenolone C21H32o2,  and thence progesterone C21H30O2,  testosterone C19H28O2, DHEA C19H24O2. and thence estradiol C18H24O2. and                                                       4 the prime adrenal mineralo/glucocorticoid steroids  cortisol C21H30O5, aldosterone C21H28O5.

But we primates and a few other species lost the ability to synthetise on demand in quantities of grams a day the crucial vitamin C ascorbic acid C6H8O6 that is key to all the above.                                                                                            And vested interests in the Disease Industry want us to believe the biological nonsense  heresy  that we must ingest minimal unprocessed foods- cholesterol, fats (especially dairy, marine oil Omega3 and medium-chain triglyceride- coconut oil)   and abundant vitamins C and D3, but eat abundant processed foods-  refined plant Omega6,  refined carbs- fructose,  sucrose, fruit juice,  cooldrinks, cereals, confections- which overload causes insulin resistance and thus lipidemia,  obesity- metabolic syndrome -diabetes, cancer and cardiovascular disease.

The Semmelweis reflexA current Wiki essay sums up the current genocidal problems of deliberate deceptions/denialism in Diet, Vitamins and causality  – for ruthless profit and possibly cynical eugenics: “The Semmelweis  effect is a metaphor for the reflex-like tendency to reject new evidence or new knowledge because it contradicts established norms, beliefs or paradigms.The term originated from the saga of Dr Ignaz Semmelweis, who discovered that childbed fever mortality rates reduced ten-fold when doctors washed their hands with a chlorine solution before examining  patients. His hand-washing suggestions were rejected by his contemporaries, often for non-medical reasons. For instance, some doctors refused to believe that a gentleman’s hands could transmit disease (see Contemporary reaction to Ignaz Semmelweis).   In his book The Game of Life, Timothy Leary provided the following polemical definition of the Semmelweis reflex: “Mob behavior found among primates and larval hominids on undeveloped planets, in which a discovery of important scientific fact is punished”. The expression has found way into philosophy and religious studies as “unmitigated Humean skepticism concerning causality“.[2]”

Idealism, ethics may evolve; but the  problem of  human bigotry, self-interest and subjective ie personal bias do not diminish, they spread.  It is classic that Semmelweis  (1818-1865) the observant innovative  Catholic medical scientist of his time (before microbes and antiseptics   were known) was fatuously condemned  not just by his jealous  competing Vienna colleagues,  but even by his progressive and reformist  Copenhagen  contemporary obgyn Prof Carl Levy (1808-1865)- who outlived him by only 4 months;

ironically at the same time that their Copenhagen contemporary Dr Soren Kierkegaard (1813-1855) was increasingly  isolating himself on the lonely ethical journey  against the convenience lazzez- faire  tide, writing for ethical life and religion against the hypocrisy  of the Church and becoming the father of both reformist theology and psychology. But unlike Semmelweis who was way ahead of the bioscience  and humanity of his time, Kierkegaard stuck to and isolated himself in   promoting the incompatible ie  blind-faith-based   religion – the dilemma of Abraham’s conviction (or delusion)  to sacrifice his son-  and ethical morality;

and closely followed by    Rudolph Steiner (1861-1925) another more  profound European  thinker who bridged  science, spirituality, progressive education, architecture, agriculture, natural medicine, nutrition,    and   social  reform;

contrary to the rationalists of the 19th Century “Age of Enlightenment” and since, like   British historian-philosopher -ethicist  Winwood Reade (1838 – 1875)  who published the enduring secularist’s bible The Martyrdom of Man (1872), of which  Churchill wrote  25 years later  “he was right but wrong to say it” on the book’s critique of the wrongs of war and religion, of mankind’s selfishness, corruption  and destructiveness (by the greedy aggressive acquisitive minority)  against the  weak masses and the environment) that carries on worse in the 21st century than even the 20th century;                                                                                                                                          and    150 years later bioscientist and philosopher Stephen Jay Gould (1941-2002) rationalized sadly   the non-overlapping Magisteria of Science and Faith, objective “provable” science – which in fact is seldom immutably constant as is mathematics-  and purely faith-based  “unprovable” religious belief.

It was only a year ago that Richard Conniff published his column on   Strange Behaviours, The Medical Martyrs. And the medical  hero martyrs in this review-  Semmelweis,  Margaret Sanger, Drummond  and Pauling –  never made it onto his list.

But then nor did  the modern medical  freedom fighters  Steve Biko,  Agostinho Neto,  Che Guevera. Jonas Savimbi, Neil Aggett, and the living spouse of Steve Biko, Dr Mamphele Ramphele….

Women of the Century apart (like Margaret Sanger, Marie Curie, Eleanor Roosevelt, Golda Meir, Indira Gandhi,  Helen Keller, Benazir BhuttoMother Theresa, Aung San Suu Kyi -many of whom have been martyred),                 it is a philosophical debate whether among the men  the medical martyr  Semmelweis (1818-1865) ranks with  his  19thC contemporaries-   Lincoln (1809-1865), Kierkegaard(1813-1855), Pasteur (1822-95), Lister (1827-1912)  ;  and his successors (and 20th C  leading achievers): Koch(1843-1910), Edison(1847-1931), Steiner (1861-1925), Gandhi(1869-1948),  Weizmann(1874-1952), Churchill (1874-1965), Einstein (1875-1955), Jung (1875-1961), FD Roosevelt(1882-1945), JK Galbraith(1908-2006), Martin Luther King (1929-68), Pauling and Mandela   as arguably giant enduring male leaders -innovators-  teachers and achievers  of the past two centuries.

Unlike eg Socrates, Hippocrates  and Jesus of Nazareth, one of the  five greatest polymath medical and ethical sages of all time Rabbi Dr Moses Maimonides (RamBam)  avoided martyrdom by burying himself in practicing selfless medical service for sultan and peasants alike, and jurisprudence   for his GreekoRoman based  Islamic-Sephardic   times and philosophy, like his guru predecessor Avicenna and his contemporary savant Averroes. .

CONCLUSION:   Today it can  be argued that the denial of effective phamacotherapeutic doses of especially  vitamins C and D3, let alone supportive doses of balancing vits (A, B1,3,5,6,9 & 12, E and K2); the often-crucially  deficient minerals (eg magnesium, sulphur, phosphate, iodine, zinc and selenium), and biologicals like human transdermal balanced HRT, coenzyme Q10, alphalipoic acid, milk thistle, cinnamon, fish oil, chondroglucosamine, DMSO, coconut oil,  is a repetition of denialism of the germ theory,  and of optimal physiological human micronutrition as well as macronutrition. .

      – especially when patients are poor and thus malnourished, and plagued by diarrhoea and stress, TB, lipidemic vascular disease and cancer; and when antiretroviral ART- although life-saving- is even more diabetogenic and neurotoxic  than untreated AIDs.

Even transdermal administration is  better than nothing, perhaps  better  (for the frail and noncompliant eg oldies) than oral or injection eg of vitamins D3 & C and progesterone , metformin, (in addition to the usual magnesium chloride, vits A, BCo & E)  may be beneficial whether by patch or cream for both healing, infection, calming,  heart, circulation, infection, arthritis, osteoporosis,   and neuritis, applied under coconut oil,  codliver oil and DMSO as further analgesic, anti-inflammatory,  memory and absorption enhancers.

REFERENCES:     New reviews bear out the major benefits of micronutrient supplements selenium,  zinc, silver, vits A, B, C, D, E;  and DMSO, sutherlandia and aloe  against HIV-AIDs. and co-infection;

Micronutrient supplementation for children with HIV infection. Irlam JH,  Rollins NC ea . Cochrane Database Syst Rev. 2013 Oct 11;10:CD010666.

Effect of micronutrient supplementation on disease progression in asymptomatic, antiretroviral-naive, HIV-infected adults in Botswana: a randomized clinical trial.Baum MK,  Marlink R ea .JAMA. 2013 Nov 27;310(20):2154-63. .

Preliminary trial of aloe vera gruel on HIV infection.Olatunya OS,  Oyelami OA. ea, J Altern Complement Med. 2012 Sep;18(9):850-3. doi: 10.1089/acm.2010.0735.

In vitro effects of Sutherlandia frutescens water extracts on cell numbers, morphology, cell cycle progression and cell death in a tumorigenic and a non-tumorigenic epithelial breast cell line.Stander A,  Joubert AM. ea, J Ethnopharmacol. 2009 Jul 6;124(1):45-60

Sulfur in human nutrition and applications in medicine.Parcell S.Altern Med Rev. 2002 ;7(1):22-44.

Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention.DebMandal M, Mandal S.Asian Pac J Trop Med. 2011 Mar;4(3):241-7

below  are some of the  most recent  94 studies  of vitamin D and human infectionin   published just  in 2013:

New insights on the role of vitamin D in the progression of renal damage: Kidney Blood Press Res. 2013;37:667-78. . Lucisano S, Santoro D.ea  Many studies indicate relationship between hypovitaminosis D and survival, vascular calcification, bone mineral metabolism, immune, cardiovascular and endocrine. Vitamin D analogs reduces proteinuria, in particular through suppression of the renin-angiotensin-aldosterone system (RAAS) and exerts anti-inflammatory and immunomodulatory effects. In particular vitamin D deficiency contribute to an inappropriately activated RAAS, as a mechanism for progression of chronic kidney disease (CKD) and/or cardiovascular disease. Human and experimental models of CKD showed that vitamin D may interact with B and T lymphocytes and influence the phenotype and function of the antigen presenting cells and dendritic cells, promoting properties that favor the induction of tolerogenic T regulators rather than T effectory. Interstitial fibrosis may be prevented through vitamin D supplementation. .

Should vitamin D supplementation be a regular part of asthma care? Gordon BR.Otolaryngol Clin North Am. 2014 Feb;47:97-108. .Vitamin D (vitD3) deficiency occurs frequently and has profound effects on health, especially asthma.

Vitamin D in asthma and future perspectives.Huang H,  Zarogoulidis K. ea Drug Des Devel Ther. 2013 Sep 23;7:1003-13.

 vitamin D deficiency associated with development of Acinetobacter baumannii infections in critically ill patients?; Türkoğlu M, Aygencel G et al.; Journal of Critical Care 28 (5), 735-40 (Oct 2013)

Association between vitamin D and hepatitis C virus infection: a meta-analysis. Villar LM, Romero-Gomez M. ea World J Gastroenterol. 2013 Sep 21;19(35):5917-24.

Association between prehospital vitamin D status and hospital-acquired bloodstream infections. Quraishi SA, Christopher KB. Ea, Am J Clin Nutr. 2013 Oct;98(4):952-9.

Human parvovirus B19 associated dilated cardiomyopathy. Jain P, Jain A, Khan DN, Kumar M. BMJ Case Rep. 2013 Aug 5;2013.

The role of vitamin D supplementation in the risk of developing pneumonia: three independent case-control studies. Remmelts HH,  van de Garde EM ea  .Thorax. 2013 Nov;68(11):990-6.

Correlation between serum vitamin D level and severity of community acquired pneumonia in young children   Ren J, Sun B, Miao P, Feng X. Zhongguo Dang Dai Er Ke Za Zhi. 2013 Jul;15(7):519-21. Chinese. http://www.ncbi.nlm.nih.gov/pubmed/23866270

Role of vitamins D, E and C in immunity and inflammation. Shaik-Dasthagirisaheb YB, Pandolfi F. J ea Biol Regul [Correlation between serum vitamin D level and severity of community acquired pneumonia in young children].Homeost Agents. 2013 Apr-Jun;27(2):291-5.

Pre-hospital vitamin D concentration, mortality, and bloodstream infection in a hospitalized patient population.Lange N, Christopher KB ea. Am J Med. 2013 Jul;126(7):640.e19-27.

Vitamin D deficiency in HIV infection: an underestimated and undertreated epidemic. Pinzone MR, Nunnari G. eA Eur Rev Med Pharmacol Sci. 2013 May;17(9):1218-32.

Vitamin D deficiency and sudden unexpected death in infancy and childhood: a cohort study.Cohen MC, Offiah A, Sprigg A, Al-Adnani M. Pediatr Dev Pathol. 2013 Jul-Aug;16(4):292-300.

Serum 25-hydroxyvitamin D3 and the risk of pneumonia in an ageing general population.Aregbesola A, Tuomainen TP. ea J Epidemiol Community Health. 2013 ;67:533-6.

Treatment of pulmonary tuberculosis.Nunn A, Phillips PP, Abubakar I.Curr Opin Pulm Med. 2013 ;19(3):273-9.

Role of vitamin D in children with respiratory tract infection.Esposito S, Baggi E, Bianchini S, Marchisio P, Principi N. Int J Immunopathol Pharmacol. 2013 J26(1):1-13.

Tuberculosis incidence correlates with sunshine: an ecological 28-year time series study.Koh GC, Dedicoat M. PLoS One. 2013;8:e57752.

Improving outcomes in patients with psoriasis.Tidman MJ. Practitioner. 2013 ;257:27-30, 3.

vitamin C refs & infection:

Authors’ perspective: What is the optimum intake of vitamin C in humansFrei B, Birlouez-Aragon I, Lykkesfeldt J.  Crit Rev Food Sci Nutr. 2012;52(9):815-29.

Micronutrients at the interface between inflammation and infectionascorbic acid and calciferol. Parts 1 & 2: .Ströhle A, Wolters M, Hahn A. Inflamm Allergy Drug Targets. 2011 ;10:54-74- FULL TEXT IS ON LINE. .

Vitamin C for preventing and treating tetanus Cochrane Database Syst Rev. 2008 Apr 16;(2):

THE TRILLION-DOLLAR CANCER INDUSTRY: QUOT HOMINES TOT FEMINA or QUOT HOMINES TOT CANKERI??

neil.burman@gmail.com

 PREFACE:  the conflict  between common sense, conventional wisdom and vested commercial interests:

Throughout the ages, innovators and believers in truth and freedom of thought  have risked if not attained martyrdom for disputing populist or autocratic wisdom or beliefs, from Socrates to Jesus to objectors against prevailing dogma through the past twenty centuries, Martin Luther, Galileo Galilei and in our time  eg Margaret Sanger, Mahatma Ghandi, Linus Pauling, Jack F Kennedy, Nelson Mandela,  Steven Biko, now even medical leaders like Dr David Graham at the Federal Drug And Food Administration itself.

But despite the eternal fact that truth will out, even now the USA and South African governments are determined to suppress truth, making it a jail offence for whistleblowers and media reporters to publicise evidence that exposes (eg medical) fact let alone corruption and worse. Jose Saramago the late Nobel-winning Portuguese author of “Blindness” and “Seeing”.  will be sadly shaking his heavenly locks.  We should heed Saramago’s modern scepticism  about official truths if not his atheism and communism.

Eleven years ago the emeritus professors Sirs  Stuart Cameron(British)  and Bill Hoffenberg (South African) at London University  dared to publish jtaboo questions for ethical debate – The ethics of organ transplantation reconsidered: paid organ donation and the use of executed prisoners as donors. This was still hotly debated in 2003- and remains so in South Africa -ironically after 16 years of ‘democratic’ majority rule  one of the most violent and corrupt countries in the world – where leading private practice doctors and hospitals are being prosecuted for transplanting kidneys from apparently desperate willing sellers to unrelated paying recipients.

The Case of Disease-Mongering?  Screening the well at average (not high) risk for Possible Future Cancer:

 The classic Latin phrase Quot Homines, Tot Sententiae- so many people, so many opinions – refers to the dilemma of which opinion to follow, what to  vote for. Politics aside, never is this more apposite than about confusing men and women about the grave risks  of the overdiagnosis and overtreatment of screening-detected silent cancers.

So perhaps the title should read: Quot Homines Tot Cankeri: not all adults may get crabs, but the screening disease industry posits that  all adults may get cancer and thus should be regularly invasively internally screened. .

We are not talking about investigation directed at a possible cancer that has already grown big enough to be causing relevant symptoms eg a lump or pain etc. It is indeed surely negligent if a health professional fails to recommend such diagnostic investigations in the appropriate clinical conditions.

SCREENING FOR BREAST AND PROSTATE CANCER: A review last month of the massive ( New Jersey Cancer Institute) study of prostate cancer bears out the futility- in fact grave risks- of screening for silent dormant prostate cancer in men without symptoms. This is reinforced by a broader recent Medscape review. 

Wikipedia usefully sums up the dilemma we face 2500 years after Hippocrates.  While Aulus Cornelius Celsus translated the Greek carcinos into the Latin  – to many of us the foods of the gods – Galen 150 years later used “oncos” to describe all tumours, the root for the word oncology; but the more thoughtful Hippocrates had long before distinguished benign tumours oncos, Greek for swelling, from malignant tumours carcinos.

We can fast-forward this distinction to 2010 in Hippocratic terms of both ethics and pathology:

1.should tumours that are histologically “malignant” but clinically static over a usual lifetime – as most asymptomatic prostate and breast “cancers” are ie “oncos” (eg screening-detected ductal or cervix carcinoma in situ) if not stirred up by eg hormone therapy or biopsy- be labelled, diagnosed to the patient as clinically malignant “carcinos” ie a spreading crab? Hippocrates , and later Celsus , were indeed talking about cancers as tumours that were clinically and macroscopically malignant. Silent preclinical cancers that are discovered on screening are rarely so. And therefore

 2.is it ethical to do cancer screening (by blood, digital, xray, ultrasound, biopsy) of all asymptomatic patients? As Shaughnessy and Slawson (1997) so incisively wrote a decade ago, is such commercially lucrative proactivity Patient-Orientated Evidence that Matters ie POEM to the patient? They continued to publicise this theme relentlessly until their last joint Pubmed-listed essay in 2006, arguing trenchantly for valid evidence-based practice rather than as most doctors seem to do, following ex cathedris views and guidelines by ‘experts’ and committees- who are likely influenced by Big Pharma. They (Shaughnessy and Slawson) individually continue this battle until now.

The updated wikipedia review  of xray screening for asympotomatic preclinical cancer including breast cancer, soberly reviews the controversy surrounding the benefits – saving possibly one extra life in 2000 healthy women whose breasts are heavily crushed and irradiated for years for no benefit, for the dozens undergoing recalls and biopsies for lesions found, the handful who may have cancer diagnosed and even surgery and radio/chemotherapy, for mostly early cancers that far more often than not would never have presented during lifetime and death from other causes.

Yet screening breast cancer xray mammography of even millions of asymptomatic women not at familial risk cannot be proven to save even one life let alone lives. The increasing doubts about the costs (both financial and emotional) of such screening versus the benefits of such screening of well persons with low risk factors including family, apply to screening for many relatively common feared cancers eg breast, prostate, testicular, ovary, lung.

SCREENING FOR OTHER CANCERS: So the question may well be asked whether there is overall statistically significant benefit (in lower overall mortality and morbidity) of such invasive screening programs even for the other two commonest cancers of older adults- colon cancer and cervix cancer- in those without significant risk factors- relevant symptoms or infections or family history.

This then extends to the longerm questionable overall benefit versus risk of vaccination especially from preteens against human papilloma virus- again, such vaccination is a trillion-dollar industry when it is decreed compulsory for all children. .  As screening for breast and prostate cancers has shown no clear benefit to individuals or to the population screened – versus the non-screened- on longterm population followup, it will take comparable careful review of results in thousands of initially low-risk well patients for decades to show whether overall mortality and morbidity was indeed lower in average-risk populations that were invasively screened/ vaccinated for eg cervix or colon cancer versus those that were not.

Only such a study will show whether the public has anything to lose by simply being mandated to report to a healthcare professional for relevant investigation when they develop new symptoms eg change in bowel or gynaecological health.   It is damning that on a populist website like Health24, the page on Breast cancer was last updated in 2006, and does not even mention the crucial issue of longterm benefit and risk on those screened. Naturally service providers with vast investments in technology and aggressive management promote screening, as witnessed by national health services, university and private hospitals and high-tech practitioners in all countries. At least the Wikipedia section on breast cancer screening has a lengthy section covering the controversy.  .

 It is now six years since surgery professors Dent and Panieri published an editorial warning about the lack of convincing evidence for population breast cancer screening. And their editorial did not even consider the added risk factor of repeated crushing and irradiation of presumably health breasts.

And a practicing USA radiologist like Dr Jeff Dach argues realistically against all such screening based on the evidence.  .  As he says, just switch off the screening imaging machines, stop calling ductal carcinoma in situ of the breast a cancer. The ongoing argument for and against screening is hotly debated by specialists supporting and opposing the vested interest of the Screening Industry.

 Without more study, it cannot be assumed, proclaimed, taken for granted that the giant resources- costs, risks, and invasion of everyones’ privacy and time,  required for such mass screening and vaccination – are justified. Are they anything more than lucrative disease-mongering? when screening xray mammography alone is already said to  gross almost $10 billion a year in USA (300million people) .

   Extend that to all countries and the five common adult genetically linked cancers,  and the cost of questionable screening (and then managing the discovered cancers) – let alone aging cancer itself) for the whole world of older adults surely  rises to above a trillion dollars a year– a nice coveted annual pot of gold for governments in power and the business moguls, big stakeholders they serve.

As with the spurious decade-long unwinnable invasion of Iraq for fictitious nuclear weapons but in reality for the profits of war and oil,

 and the USA – European Union -WHO declaration of a swine flu pandemic just a year ago so that the NATO business buddies – governments and their funding private megacorporations – could reap billions in immediate rake-off from unproven screening tests and vaccinations and drugs;

and its trillions a year from uncovering and treating all those sleeping cancers, 

 so who cares about the benefits and risks decades down the line for those screened and vaccinated and treated now for disease that is unlikely ever to occur?

BIG PHARMA-US GOVT CONSPIRACY FRAUD: THE NEVER-ENDING STORY OF DESIGNER SNAKEOILS- VIOXXES, FOSAMAXES, PSYCHOTROPES…

neil.burman@gmail.com  20100630

Pharma Fraud: the saga continues:

So Merck is also paying out $4,5billion to settle Vioxx damage cases…

  and now    Fri, Jun 25 2010  Jury orders Merck pay $8 million Fosamax damages 

 But as this column has described for almost 3 years  now, over 3000 cases of bisphosphonate osteonecrosis had already been  reported worldwide by 2006; the first case having been reported in about 1996.    

    And  leading university clinician Professor Dr  Scott Reuben gets a slap on the wrist 6 month jail sentence and > $300 000 fine for consistently faking drug  results ( Vioxx, Bextra, Effexor and even Lyrica ) for Merck and Pfizer- to bolster their multibillions sales. How much has he been paid / guaranteed to retire luxuriously remains untold.  

 So Meck now leads Pfizer ($3.4billion admitted  so far) in fines and damages penaties-  but both Pfizer    and Merck  still face untold billions in fines and damages in current ongoing litigation against them.  And worse to come- Merck and Bayer face massive damages claims over their contraceptives . This apart from the bakers’ dozen of shady practices listed against Bayer, of unquantified costs.    

  I recently saw my first associated case, a postmenopausal woman who had to have all her teeth removed and implants done after they came loose after a  few years on a bisphosphonate for osteoporosis prevention.  But perhaps my mother-in-law’s spontaneous cornflake collapse  of her lower femur in 1998 was my first case, someone had put her at about 70years  on bisphosphonate a few years before. She has never walked since, despite repeatedly failed  knee replacement. .

  There never has been the slightest  proven clinical justification for taking Vioxxes- Celebrex- Voltarens for pain, or bisphosphonates for osteoporosis/osteopenia, since there are safe  long-proven more effective natural painkillers, and safe supplements which restore normal bone without any risks, and (unlike bisphosphonates) with multisystem benefits that reduce all major common  degenerative diseases by 1/3 to 1/2 .   These modern synthetic designer drugs like bisphosphonates,   nonsteroidal anti-inflammatory “painkillers” ,  statins- cholesterolbusters, hypoglycemic drugs which actually promote obesity, neuro-drugs like  Neurontin, Lyrica, and Prozacs – Effexors, were and are  invented  to deceive patients into taking  lucrative $billion-dollar a year patent prescriptions  for widespread “prevention” and treatment, instead of the original natural supplements like eg herbs, biologicals, vitamins,and minerals which give relief and address the real causes with minimal risks and at low cost.        

 This  catastrophic fraud of Big Pharma- fostered by governments (for massive tax profits, job creation and ‘kickback’- God forbid that they are called bribes ) is  now exceeded in size only by the biggest Big Pharma scam ever,   last year’s  false swine flu pandemic scam  set up between the US government and Big Pharma, with multibillion dollar profits from unproven-value  mass testing,  vaccination and Tamiflu of unknown future disaster potential like thalidomide and stilbestrol proved to be.    (which in turn is exceeded perhaps by the biggest scam ever of modern times- the 2nd Iraqi war of GW Bush-Dick Cheney- Donald Rumsfeld- Halliburtons   that has now run most of this decade, the $Trillion War of Jo Stiglitz which will cost future generations of American and UK taxpayers infinitely more than that in compensation for injuries and deaths and debt; when there never were grounds – other than limitless oil to be pillaged- to invade Iraq any more than any of another dozen repressive dictatorship, when the obvious target against  Al Quaeda was always Afghanistan-Pakistan. )  

And the USA Govt and WHO (and hence most countries’ sheep -like regulators) actually changed the definition of a pandemic last year to perpetrate the trill$megabillion  swine flu  scam, and forswore proper randomized controlled clinical double-blind trials  to justify the vaccines and Tamiflu; and conveniently declared masses of old vaccine stores that were legally past their expiry date as recertified for use; and actually indemnified the vaccine manufacturers they chose against any future liability for failure of or complications from the vaccines.  

 Thus  the current USA government -with the backing of coerced allied governments  – invented the so far unproven if not risky swine flu vaccines, then handed the  recipes over to chosen manufacturers for free to produce and make $billions each within a year- with no liability –  at the incalculable expense of present and future taxpayers already reeling under the onslaught of USA-provoked overseas wars and  gigantic banking and oil cartel scams carefully orchestrated  by  deliberately failed  government   “regulation” which have caused the worst western global financial depression and environmental pollution  ever. .  

But these Big Pharma mafia  companies are bigger than the economies of many countries – apparently up to >8% of American gross domestic product- so they are protected by governments as too big to  jail or  close for fraud!   They couldnt care less about a few billion dollar fines  and damages for which they budgeted under cost of business- eg Bayer  last year paid $68billion for Wyeth the HRT  (Premarin- Provera) giant in North America…  

 As this column has previously reported,  the late greatest economist of modern times Ken Galbraith  would have said that  Big Pharma truly  rerpresents   the bared  backside  of western capitalist social democracy Naomi Klein’s  disaster capitalism (led by the modern pioneers of Human Rights for their own citizens if not their vassal dominions  – UK, Europe and USA)   – –  at its foulest .

ABANDONED DOCTRINE OF TRUTH IN MEDICINE: POSTMENOPAUSAL HRT:USE HUMAN TRANSDERMALS. WHY RISK TABLETS? BIG PHARMA WINNING THE DISINFORMATION WAR.

 5 June 2010. neil.burman@gmail.com 

Part 1: Transdermal better than oral estrogen for replacement: the importance of appropriate HRT.

part 2: Information warfare, Big Pharma, Appropriate HRT and the Doctrine of Deception.

PART 1: TRANSDERMAL BETTER THAN ORAL ESTROGEN: THE IMPORTANCE OF APPROPRIATE HUMAN HRT OVER PATENTED MEDICINES :

The  health bite today from the BBC  correctly highlights one of the many critical reasons why appropriate routine Hormone Replacement HRT should be taken permanently  by any route  – but preferably transdermally, not as tablets.  In the appropriate low human dose HRT reduces the natural risk of stroke- and of the far more common chronic major diseases that cripple and kill – ie heart disease, cancer, fractures, dementia..

  But the Menopause Societies (South African, British  and  International) ie BMS , SAMS ,   IMS , and  the BMJ must promptly issue strong statements to the media condemning the BBC again for its typical misleading  elementary misreporting- in this instance  as regards progestins..  

 Transdermal and oral hormone replacement therapy and the risk of stroke: The source report –  this week’s BMJ –   describes HRT use in UK over about 6.7years among postmenopausal stroke victims mean age 70years (50 to 79) compared to matched controls without strokes. But the inexcusable error in the BBC report is that it twice mentions progesterone as being quoted in the BMJ study- which is nonsense.  The  BMJ report never mentions progesterone,  it repeatedly says progestogen -ie synthetics progestins since these were and are deliberately and wrongly routinely prescribed (instead of progesterone) for HRT due to manufacturer-led market disinformation.

  Progesterone is the original natural progestogen- but no major drug company promotes it, so it has been rarely used except by thinking women who prefer to use prime ie human – bioequivalent- hormones!  

In the adjusted risk statistics, lowdose transdermal estradiol TD replacement  0.025 to 0.05mg a day lowered stroke risk by 19%; whereas the average gynecologist’s  arbitrary  patent pharmacological oral  dose (20 to 40fold higher than the TD dose)  of  about 0.625 conjugated estrogens CE equivalent to 1 to 2 mg estradiol OET ) a day increased stroke risk by 35% . Thus, in contrast to lowdose estradiol  TD which reduced the natural stroke rate, OET  and highdose  estrogen TD  increased the stroke rate by 50% – 90%.  

COMPARISON WITH USA WOMENS’ HEALTH INITIATIVE WHI:  the WHI  showed that on premarin 0.625mg/d the absolute  risk of stroke in USA women age 50 to 79years was about 0.3% ie 3 cases per 1000 women per year -but about 45% higher in depressed women on antidepressants. And  depression is even  more common after midlife, especially without HRT. This cohort from the volunteer WHI trial  was a mean of 63years at enrolment ie 7years younger than the British real-life cohort; and since the risk of stroke approximately doubles with every 10 years of aging, the basic risk in the British study women may have been about 5 cases per 1000 per year or 33 per 1000patients over the duration of the British stroke and HRT study. ie annually 4 cases per 1000 on lowdose estrogen TD versus 6 cases per 1000 on OET 

Despite vast evidence  that physiological replacement doses of the human hormone progesterone (the original progestogen in humans) has endless benefits for older adults, doctors, government clinics and committees overwhelminglly still are lead by the marketing hype of drug companies (and the regulators  lobbyists and governments they fund) to use  drugs designed for profit  eg xenohormone progestens that they wish  were and falsely claim are as good as the original one that our bodies produce.

Truthful information  on HRT for women is widely and easily available from even Wiki    and the real authorities like the British and International Menopause Societies, and any university department of gynecology. .   Thus today’s BBC report reflects the BBC’s willful  neglect  of the most basic check of its facts before publishing health bites. In this case, it misleads women that  conventional combined oral HRT (in fact containing the synthetic progestin that most drug companies and doctors encourage women to take) is beneficial in somewhat lowering the risk of stroke  (never mind womb cancer) – whereas such synthetic progestins. progestogens   especially in oral HRT have numerous sinister other adverse effects  eg breast cancer and heart disease,  compared to the numerous proven benefits of  lowdose human progesterone. .

KEEPS: THE DEFINITIVE HEAD-TO-HEAD TRIAL OF APPROPRIATE HRT: ORAL vs NON-ORAL ERT WITH OR WITHOUT PROGESTERONE.: The small but definitive 5year KEEPS double blind randomized controlled trial RCT is now more than half way through and due to report in 2012, comparing the alternative regimes in women in the early menopause (10years younger and less overweight than in WHI) . “ KEEPS is a multicenter trial that will evaluate the effectiveness of 0.45mg of conjugated equine estrogens CEE Wyeth Premarin, a weekly estradiol TD Climara patch delivering 0.05mg estradiol a day -( both in combination with cyclic oral, micronized progesterone (Prometrium Solvay) 200mg for 12 days each month), and placebo”.

Recent information from KEEPS is that it is proceeding smoothly, with no significant differences so far between the three arms- no increase in serious adverse events has yet been seen by the Independent Monitoring Committee in the still unblinded results.  

 Wyeth (now Pfizer since 2009) is not crossfunding KEEPS, although they may be hoping that  their premarin in lower dose will prove to be as safe as or better than estrogen TD in the medium term.. But given the ~70year experience with oral HT mainly premarin 0.625mg/d promoting breast cancer increase (although not mortality) after >12-15years of use , it is remotely unlikely that even ¼ of the long-standard premarin oral dose will prove anywhere as safe and effective as parenteral balanced human hormones for permanent protection in aging women.  One hopes it is, to vindicate the insistence of so many doctors on still prescribing OHT for  even just the first 10 years of menopause,  despite so much damning evidence to the contrary (see this entire website of reviews).

SO WHY PRESCRIBE, RECOMMEND HRT PILLS FOR POSTMENOPAUSAL WOMEN? when hard evidence is that non-oral  balanced human HRT (appropriate estrogen, progesterone and testosterone) is far superior in both benefits and zero risks for women? Whereas it is common cause that conventional oral HT ie about 0.625mg CE or equivalent started at menopause increases the  early risk of dangerous deep vein thrombosis DVT; and  begins to increase the risk of breast cancer to above that of untreated women after a cumulative dose of about 2 – 3 gms oral estrogen – after 10 – 15years ie by prime post retirement midlife in the midsixties. It is only some compensation that other cancers, fractures, ischaemic heart disease, dementia and (breast cancer- and all-cause) mortality, are reduced by appropriate m0dest doses of such OET combined with appropriate progestin; but such regime increases the risk of DVT, gallstones and fatness frailty- increasing body fat with increasing muscle wasting due to collagen loss which also promotes increase in the natural tendency to fractures and urinary incontinence by the midsixties.

Promoters of oral estrogen, bisphosphonates, SERMS,  and strontium cleverly ignore the hard fact that by far the greater risk for aging fractures is not bone density but muskuloskeletal ie failing bone and muscle strength and global co-ordination – which bisphosphonates do nothing to promote, while estrogen and strontium nad SERMS  may promote bone strength but not crucial muscle strength, and SERMS double the laready very high rate of stress urunary incontinence. .

  American major authorities do anything to promote their own commercial interests.  so they have long given their drug regulator the FDA – which is unashamedly paid for by big pharma- unbridled licence to make nonsensical claims and draconian laws. And because drug companies fund the FDA and the lobbyists and legislators in USA to promote their  products, (in a $trillion disease industry – some 8% of American GDP) they have the vast profits to in turn influence medicines regulators and legislators throughout the world to follow their profitable lead.

So  only the FDA and regulators  decide what foods are good for people, what supplements (of microfood stuffs) people may take, and licence designer synthetics for human prescription after trials of only a few months in a few hundred subjects – but insist  that old proven nutritional remedies may not even be claimed to have any health, preventative and therapeutic benefits unless they have undergone massively costly controlled trials that Big Pharma will never fund.

 Their hypocritical deadly nonsense is then to use draconian measures to stop suppliers from making any health claims for even supplements that are well known to be gold standards for prevention and treatment eg fish oil and the scores of other highly effective and safe biologicals- minerals, vitamins, human (eg glucosamine, chondroitin, n-acetylcysteine, coQ10, arginine, carnitine, carnosine), and plant products- that are (co)-hormones, antioxidants, true anabolics, nitric oxide promotors, anti-inflammatories, antidepressants, memory and vision promotors, neurotropics, insulin sensitizers, antiatheroma, hypolipidemic , antimicrobial etc. .  

In fact they now proclaim that citizens may not even buy supplements, foodstuffs  or even legally prescribed compounded hormone creams made from legal components (as are all other prescriptions made by manufacturing pharmacists practicing alone or in Big Pharma), unless the FDA has proclaimed them safe, because “they have not been proven safe”.

 This despite the facts that most  enduringly successful prescription drugs  (eg reserpine, metformin, digoxin, the synthetic progestins) are derived from/ based on successful evolution of and human experience  with the parent supplement eg vitamin, mineral and other biologicals  (eg non-oral progesterone, estradiol, testosterone)  over thousands of years,   and millions of patient years experience  in the past >100years of scientific discovery. 

The Disease Industry- FDA-Big Pharma – organized medicine international network- proclaims that no claims may be made for the benefits of supplements (the vehicles, parents  of most prescription drugs in use) unless they have been tested in rigorous trials to the same standards as designer drugs are recently tested.  

Yet the FDA and regulators allow the marketing of generics- chemical identicals but often far from identical pharmacology and therapeutic action- without clinical trials. Where is the logic for the vendetta against supplement creams  like individually compounded bioidentical hormones that produce measurable physiological levels and appropriate relief?

 This despite the fact that millions of patients have been and continue to be  damaged (iatrogenesis that results in vast numbers of hospital admissions and deaths annually) the past 50 years by drugs promoted by the FDA at the pushing of Big Pharma, based on far too short poor and often fraudulent reports which the drug industry ruthlessly manipulates.

  This led to the disasterous use of stilbestrol in pregnancy from the 1940s to the 1970s;         to the disasterous registration and extensive liberal prescription – in many cases even promotion over-the-counter- of practolol, thalidomide,  chloromycetin and other antibiotics;     potentially fatal unnecessary patent anti-inflammatories  up to the Cox2   inhibitors (eg Vioxx, celebrex) as painkillers;  barbiturates benzos and antidepressants;   lately sulphonylureas and glitazones as firstline drugs for type 2 diabetes instead of the gold standard metformin; new antihypertensive drugs as firstline therapy instead of the goldstandard lowdose amiloretic plus reserpine; appetite-weight suppressants instead of metformin;  bisphosphonates for osteoporosis instead of the goldstandard combined dozen vigorous vitamins minerals and sex hormones that halve all major diseases; and statins for uncomplicated mild to moderate cholesterolemia  instead of goldstandard combined minerals vitamins  metformin and HRT.

  And the simple fact that drug companies  will no longer risk funding head to head trial of one of their profitable drugs against gold standard old drugs or supplements of proven great all-disease medicinal value; since prevention does not pay- only disease pays.

The cost of protectionism for the lucrative Big Pharma industry – for the sake of trade and taxes – is vast  as witnessed by governments sponsoring eg statin , H1N1 flu vaccines , modern antidepressants, bisphosphonates and nonsteroidal anti-inflammatories, and when each of these products of unproven benefit in mass use nets the manufacturers  obscene multibillion dollar profits- in the case of vaccines, with 100%  indemnity guaranteed them at taxpayers’ ie the consumers’  expense!

The lesson from the new UK  study of oral versus estrogen TD is that appropriate ie balanced physiological-dose  human sex hormones are the logical 1st-choice prevention and treatment for postmenopausal women (and their peer mates) – not the multirisk wannabe synthetic substitutes that  Big Pharma keep hammering on the public- new psychotropes, NSAIDs, Cox2 antagonists, statins, bisphosphonates which lack the multisystem benefits of physiological balance of evolution-evolved natural micronutrients ie nutriceuticals.

Part : 2. DOCTRINE OF CENSORSHIP and DECEIPT;   vs DOCTRINE OF TRUTH/… see next review above this.

UPDATE: THE FRAUD OF BIG PHARMA MODERN CHRONIC DRUGS

neil.burman@gmail.comUPDATE: see 14 June 2010. The Statin Scam Unravels. 

 

Update: 6 May  2010: this week’s recall of Johnson and Johnson’s Tylenol, Motrin, Zyrtec, and Benadryl due to negligent contamination , in particular of Tylenol for children, leapfrogs America’s household favourite Johnson and Johnson J&J to 2nd place (with at least 6 bad drugs) in the fraudsters mafia roll of dishonour behind the unreachable leaders Pfizer with about a dozen notorious fraud drugs. What is another $81million fine to J&J  that had sales of >$63billion in each of the last two years with profit of above 20%, and that despite the recall still maintained this turnover in quarterly sales for the 1st quarted this year? 

The major thing is that despite J & J’s gross negligence endangering the lives of children, the FDA has taken no other action against them. They terrorize  with armed marshalls  for trivia and shut down small firms making safe health supplements and physicians using them, but the Big Pharma mafia are the darlings of the FDA and Government since they pay such vast amounts in fees and taxes to Govt and lobbyists- politicians and academicians- trialists – that they are untouchable in every country.. 

14 April 2010: So we  can throw away the fraudulent  Pfizer’s fraudulent Neurontin gabapentin  we have been taking? when there never was  evidence that it is as good and safe as it’s parent (our chief brain neurotransmitter aminoacid )  GABA; while it’s younger twin sister  Lyrica – pregabalin– designed  for extension of patent benefits –  is worse  … just like we can throw away the chronic nonsteroidal anti-inflammatories eg Voltaren diclofenac , Vioxx and Celebrex  that are  such heart risks, poor painkillers,   and do  nothing for the underlying destructive chronic disease process. Drugs for massive profit for the beloved Big Pharma Industry that  politicians go to endless lengths to protect.- even Obama and George Brown as witnessed by the multibillion dollar swine flu scam, even now  in 2010 with Obama’s Pharmacare bill. 

 And now Harvard  University shows that even Neurontin and lamotrigine  increase the risk of suicide by42% and 81% respectively. So the long list of fraudulently overmarketed  or hazardous -improperly registered  or prescribed drugs  without adequate trials or obligatory definite  indications-  grows. 

And then there is the Disease Industry hypermarketing technique of Diseasemongering-  promoting previously ignored or unrecognized variable human traits like anxiety, insomnia, lowgrade depression, mild  hypercholesterolemia, female low sexual desire, erectile dysfunction, postural or stress backache- to diseases requiring permanent designer drug therapy eg benzos, viagras, prozacs, statins, NSAIDS nonsteroidal anti0inflammatories;  or “corrective surgery” for all. 

Pfizer,  Bayer, GSK  and  Roche  with the 100% support of their respective government regulators and politicians   continue to vie for top place as the biggest fraudsters of all time – competing with  the food, tobacco, booze, media, vehicle, financial, lawyer, minerals, fuel  and politics  industries..   

Why is this? Because the public – taxpayers and the poorer consumers- are at their most vulnerable, pawns if not cannonfodder and guineapigs  when it comes to trust in government regulators and the giant consumer product  industries – manufacturers and big distributors-  that Govts  regulate – especially the disease and drug industries.  

  And government regulators are controlled by elected politicians   who ( apart from a few altruistic successful honest folk who stand out and are nominated for  or called to office -but not Ralph Nader) –  as  mostly  lawyers or failed businessmen/ workers or carreer trade unionists,   rarely seek higher office  except to further their own financial interests and power lust.   

Winston Churchill and Frank Rooseveldt vie with Margaret Sanger, Mahatma Ghandi  and Nelson Mandela  for honour as the leading persistent (western)  fighter for justice, human rights of the 20th century if not all time, since they were skillful – brave  but above all tough enough (unlike many heroic martyrs) to survive to see it through. 

Hence there is enormous incentive for collusion between politician/ government officials who control the taxes and spending thereof,  and the big businesses that control the big money that escapes the tax officials – including Big Pharma. In South Africa there is no incentive whatsoever for the MCC Medicines Control Council Regulator to work efficiently as all income it generates is absorbed by the Fiscus/Dept Health, which blatantly refuse to produces annual financials for the MCC – effectively a parastatal supposedly under an independent CEO and Board. 

 Below is a list of costly modern disaster or dubious largely chronic drugs and their manufacturers that earn  the profound distrust of consumers: (where there are a proliferation of me-too analogues in a group eg benzos, statins, NSAIDS, bisphosphonates, only the original one or two are listed since they led/lead the pack): 

PFIZER -Wyeth -Searle – Upjohn:  Neurontin; Geodon,  Bextra,  Zyvox,  Lyrica; Lipitor;  Celebrex; PremPro; aspartame; Rezulin;  Viagra; and Ativan=lorazepam/ Xanor=alprazolam – two  of the most addictive   chronic  “anxiolytic” benzos – again, in Wiki and MIMS their  indications are far fewer than the pages of problems they  cause us since the 1970s , papering over and masking symptoms by numbing the mind (as with alcohol and smoking) instead of patients addressing the underlying cause of their anxieties with psychotherapy including learning self-hypnosis control.   

Collectively, Pfizer (the conglomerate of rash clones it has swallowed) has as many modern disaster/fraud  drugs as the next two combined of its  major league fraud competitors: 

Johnson & Johnson – Risperdal  ;   prepulsid;  Tylenol, Motrin, Zyrtec, and Benadryl 

Bayer – Trasyol; Yaz/min Baycol, Paxil, Flonase, Cipro; 

Astra-Zenca – I.C.I. – Seroquel, Nexium ; Crestor,Tenormin, Losec; and thalidomide.. 

Roche  – Xenical, Roaccutane, Tamiflu; Valium. . 

Glaxo-Smith-Kline  GSK -swineflu vaccine; Avandia, Paroxetine. 

Sanofi-Aventis (Hoechst-Rhone-Poulenc)  – Actonel  ; benzbromarone;  swine flu vaccine; Cosaldon -Trental [Cosaldon R was an excellent peripheral vasodilator oxypentifylline plus vitamin E; then Hoechst subtly started downplaying Cosaldon R as it’s patent expired, and introduced the slightly phonetically changed  and far more costly ‘new’   drug Trental pentoxyfylline.. Hoechst would naturally not explain (except obviously on grounds of profiteering from the new patent substitute)  why they substituted an inferior “new”  drug for the better  older version which included the safe dose of vitamin E.] 

 Merck – Vioxx; Zocor,   Fosamax; gardasil. 

Eli  Lilly – Prozac, Zyprexa; memantine ; and DES-diethylstilbestrol, perhaps the most infamous of all commercialized drugs in causing problems even in grandchildren of those so recklessly exposed to it without evidence of benefit. (Eli Lilly was the last company to stop manufacturing it – in 1997! despite evidence of it’s disasterous effects published in 1953, and of cancer from 1971 . ) 

Novartis -Ciba Geigy- Voltaren, swineflu vaccine. 

Abbott labsMeridia=Reductil   

Biogenesis labs – Acomplia; rimonabant  

Bristol-Myers Squibb -Pravastatin;   Plavix, warfarin; And the sustained  cover-up of the COSMIC  metformin  obligatory postmarketing trial  done at the insistence of the FDA on a huge 9000 subjects for 1 year in about 1996/7.   This trial was eventually submitted for publication only in 2004 and thus published in 2005- but for the previous year  BMS and their licensor  the original patent-holder  Merck  denied any knowledge of such a trial although the summary was presented and published a year earlier at a US diabetes congress by the authors, and we supplied the COSMIC abstract- written by BMS researchers who did the COSMIC trial- to BMS and Merck… .        why would BMS and Merck  delay publication of this trial  for so many years, and blatantly deny knowledge of it after the first report of the trial result at a USA diabetes congress ? 

The answer can only be the predicted- because it confirmed in the biggest metformn trial cohort ever- 8000 patient-years- that metformin in diabetics gave zero significant adverse drug effects, with the all-cause deathrate in fact 9% lower than in those on other conventional antidiabetic therapies; and  four major diabetes prevention  trials of metformin in four continents confirmed that it at least halves the incidence of new diabetes- with zero significant adverse effects; and in the intervening years between this trial and it’s result publication, both BMS and Merck developed and launched their respective combinations of metformin and a sulphonylurea (M + SU) . This despite the fact that it was clear since at least the 1970s that the addition of sulphonylurea to  metformin is a desperate last resort since it is fraught with risk of hypoglycemia and reversal of the reduction in fatness produced  by metformin alone.           

A new  retrospective study just published from the UK patient database confirms the  folly known all along  of combination of SU with metformin in that  that over a mean of 4 years on therapy, the metformin+SU therapy reduced all-cause mortality by 23% compared to SU alone; while metformin alone compared to SU alone reduced mortality 1/3 more ie  by 30% – with trivial risk of hypoglycemia. This was similar to the outcome in the 20year UKPDS RCT, where metformin reduced all-cause mortality by 36% over a mean of 13 years, making it the safest and most effective  drug ever patented for  chronic degenerative  disease. . 

And note the cynical folly of the many manufacturers of the grossly overpromoted and overprescribed  bisphosphonates and statins  – which  have numerous serious adverse effects and  should be last-ditch therapy in metastatic bone cancer and in rare  serious hyperlipidemia, not for osteoporosis, not for mild to moderate lipidemia and certainly not over-the-counter as profiteers crave. 

ENDURINGLY BENEFICIAL MODERN CHRONIC DRUGS: 

The above drugs contrast with vey  few modern chronic designer drugs that are still the leaders in their fields, whether as original or generic – although none of them has been shown to address all-cause mortality and pathogenesis. 

Pfizer’s Norvasc=amlodipine  is a rare modern designer exception – dating from the late 1980s,  it’s patent has only just run out-  proving it’s enduring worth for longterm hypertension therapy as the premier 4th-line drug to add when reserpine 0.125mg plus amiloretic 1/2 (ie HCT 25mg + amiloride 2.5mg)  daily are inadequate for optimal control; with very low risk of serious adverse effects. 

BMS’  Captopril & Merck‘s  Renitec – angiotensin converting enzyme inhibitors ACEI –  date from the mid-late ’70s, and while they were and are the first of the invaluable ACEI inhibitors, 5th line antihypertensive drugs for common use, they have formidable potential for lifethreatening adverse effects- but they are on essential drug lists. In the past dozen years big pharma has attempted to substitute angiotensin 11 receptor blockers ARBs, for the aging ACEI,   but a recent metanalysis shows that neither group of drugs significantly lowers fatal or nonfatal cardiovascular events- and they all (unlike reserpine + coamiloretic + amlodipine) have risk of life-threatening  adverse effects. 

DRUGS FROM THE GOLDEN AGE: 

Virtually all other current  designer drugs of enduring and safe worth for chronic longterm use originated from the golden era of innovative and enduring designer drugs mostly around WW2 up to the 1960s: 

The modern  birth control OC pill taken chronically  by millions of women for up to decades for either contraception or symptom control, certainly dates enduringly and endearingly  from the post war Golden Era  as     Estinyl (Schering 1930s)  , with  or alternatively just a  progestin. Modern preparations are relatively so safe that they are the preferred contaceptives for millions of young women.  But we have just seen two young women unwisely started on Bayer-Schering’s Yaz/Yasmin develop in one case hypertension and major weight gain, the other hives- so such innovations are not necessarily better than established brands of OC . 

MSD’s 40year old Sinemet still the firstline gold standard for Parkinsons; Moduretic- amiloretic/ amilozide- still the first drug and permanent baseline  (in low dose eg half tab3 x a week or 1/4 – 1/2 a day) for hypertension; Epilim valproic acid for epilepsy; Tryptanol; 

Sanofi-Aventis Hoecht’s Lasix furosemide still the leading diuretic for  chronic severe heart failure, cirrhosis, nephrosis. 

Merck’s 80yr old metformin- the only laboratory – originated drug (a teak of the galega plant’s biguanide) that reduces all-cause mortality – by no less than 36%, without a single serious adverse effect or mortality if sensibly used; 

Bayer’s Adalat; Aspirin (1899) ; prednisone; 

Novartis-Ciba-GeigyImipramine-Tofranil the first successful commercialise and still enduring major antidepressant. 

Roche’s                            Rivotril; 

Abbott-Knoll                Isoptin; 

GSK’s  Zyloprim;   Imuran;  Panado- still the lead patent mild-moderate painkiller, safe at prescribed dose. 

Pfizer -GDSearle’s  Aldactone; Sulfasalazine; and the 100year old phenytoin -Dilantin, still a longterm lifesaving antiepileptic despite occasional major adverse effects. 

Boot’s  Brufen-  the NSAID nonsteroidal anti-inflammatory drug on Essential Drug Lists,  altho there is no evidence that this group of drugs is essenntial since they do not alter the course of the underlying chronic inflammatory disease or reduce longterm mortality and morbidity, are little if at all better than Panado+- codeine as painkillers, and have formidable risks. http://en.wikipedia.org/wiki/Ibuprofen#History  

Astra-Zenca-ICIs   Inderal was the first of the major new cardiovascular protectant beta-blockers which  are essential drugs., altho all have formidable potential adversity ; as with ACEI, no special optimal favourite has yet emerged;  they have some special chronic indicatiions, including heart conditions and special cases of hypertension. . 

THE BIG PHARMA RAINCHECK  MONEYSPINNERS: 

The US drug industry is reputedly worth >$100billion a year and the biggest industry to >$200billion; and globally some $643 billion, of which the United States produces almost half.  The gross industrial output in USA was apparently about $26 thousand billion in 2008 ie the drug inductry alone approaches 8% of total gross manufacturing output there.   

 It is surely no co-incidence that virtually all  the above  common fraud-drug  pharmacy companies are among the dozen top money-spinners listed on 2009 financials.. But perhaps the biggest racketeering of modern times has yet to be quantified, perhaps  $100 billion  of wasted money on last year’s swine flu  “pandemic” that never happened, in futile mass screening lab tests and vaccines and Tamiflu – giving massive profits  (some companies claimed >$6billion) with total indemnity against litigation to Roche, GSK, Novartis,  Baxter,  Sanofi et al.. The USA-dominated WHO hastily changed the core definition of pandemic early in the North American outbreak so it could declare the nonsensical pandemic to suit the pockets of the profiteering American-European conglomerate and the political lobbyists they employ in Government and beaurocracy… 

 So do we wonder why we can’t trust Big Pharma prescription drugs and doctors’ judgment? Read the stats of a 5years study of the relevant risks,  of  deaths from prescription drugs in USA ( versus natural supplements)  exceeding  over 106 000 to 1.   Thats why Big Pharma and it’s “regulators” like the US Govt FDA, the UK MCC, European medicines Authority EMA, and organized doctors, are so desperate to stop the public buying the supplements people choose- when early and permanent use of balanced natural supplements at least halve serious disease and thus medical consultations, prescription drug use and hospitalization. For profit, only disease (not prevention) pays. 

Of the  103  drugs that achieved  $billion sales  in 2006,: considering the chronic  disease drugs, only valproate and J & J’s contraceptive dates back to the 1980s; Wyeth’s Premarin-Prempro dates back to 1995; and  (omiting duplicate entries) only 33 were oral drugs for chronic major common degenerative (as opposed to infective or malignant or autoimmune )  diseases.  And of the ~33 , only  10 (in descending order of sales value on that list)  even vaguesly justified their  ranking and sales- amlodipine, venlafaxine, bupropion, metoprolol, Viagra ,carvedilol, valproate, ramipril, paroxitine and premarin- 

Reuter’s forecast of the 10  >$5billion raincheques for 2010  include in descending rank for common chronic diseases only the tablets Lipitor, Plavix, Diovan and Crestor- none of which are  proven essential drugs for common average disease use. They are there solely because of heavy marketing by Big Pharma, despite their mediocre results and major potential risks, with far better results given by long-proven natural supplements or by lowdose reserpine-amiloretic combination, then amlodipine . 

Finally, landmark  drugs that were not invented by, or were laregly ignored by,  suppressed by drug companies as medicinals: 

EDTA ethilenediaminetetraacetate was invented 80 years ago but never patented by Big Pharma as a medicine. Yet as an oral nutritional supplement in modest dose it is perfectly safe, and removes toxic lead, mercury, iron and many other heavy metals  (now routinely polluting the environment -food and water- chain)  from the body,  as well as uric acid– being effective preventative against gout, and an antiatheroma agent. It is apparently not a scheduled medicine in either USA, UK or South Africa, being a routine ie harmless – beneficial- food  additive preservative. 

Yet despite the vast evidence favouring fish oil, metformin and EDTA as perfectly safe and effective chronic  anticoagulation, the Disease Industry persists in promoting rat poison- warfarin, dicoumarol– as the common chronic anticoagulant, despite its’ proven risks of promoting hemorrhage, fractures – already known since at least 1998vascular calcinosis already known since 1998 and most recently published last month; and even cancer .   

Metformin is unique, the widest multidisease panacea ever extracted (from a traditional antidiabetic plant)  and patented. Like EDTA it was eventually identified in 1922 by university researchers Werner and Bell in Ireland – but only patented  and produced for routine diabetic use since the 1950s- and deliberately obstructed for use in the USA for another 40 years by the FDA and Big Pharma, which were busy as bees designing and mass marketing far less safe and effective USA sulphonylureas although these were already discredited by the  UGDP  almost 50 years ago, when metformin was ‘rediscovered’ and came into its own. 

Reserpine  also a plant (rauwolfia) extract  remains (with coamiloretic, amilozide)  both in low dose the first-line drug treatment of all classes of hypertension– which since the prevalence of this disease now approachines 50 % in aging adults, makes these drugs amongst the most prevalent essential drugs needed. As even wiki says,  from many major studies over decades, “Reserpine is one of the few antihypertensive medications that have been shown in randomized controlled trials to reduce mortality” – in at least a score conclusive trials of the individual components reserpine, thiazide and amiloride, the triple combination is by far the best firstline therapy, at a cost in South africa of about  $US1 a month.. . But Big Pharma and its profiteer lobbyists continue to suppress the combination fraudulently based on decades-old overdosage data. 

By contrast well over 100 natural micronutrient substances – cinnamon, garlic, ginger, codeine, reserpine, digoxin, huperzine A, galega-metformin and many other plant extracts; vitamins especially B,C,D  in higher dose; , minerals especially calmag,  zinc, chromium, boron, iodine, iron  and even lithium; and human biologicals that deplete with aging like glucochondroitin, CoQ10, acetylcysteine, arginine, cartnitine , GABA, 5HTP  and almost 20  other hormones  replaced chronically – provide almost every chronic major degenerative  disease with the best prevention and treatment, without the almost invariable  risks of  the modern designer chronic drugs discussed above. 

 Since alcohol and tobacco, salt and sugar are still freely sold over the counter OTC  without any restrictions except some  to children , the commonest causes of chronic degenerative disease in more than slightest daily usage, it is obviously lowdose vitamin K,  vitamin C and D, lithium, magnesium, reserpine, metformin- galega  and EDTA that should be mandatorily supplemented in the food chain for the fattening aging 1st-world populations, and allowed OTC purchase;  while indications are severely limited  for prescription of sulphonylureas, statins, bisphosphonates and the dozens of other disaster or dubious  designer drugs listed above.