(No emergencies or surgery- these must go to nearest polyclinic or hospital ER). .
or consultations by Telephone/email where appropriate.
update 7 November 2015: comments & feedback please.
Orthoiodosupplementation in a Primary Care Practice Jorge D. Flechas, M.D. its undated but the latest ref is 2004..
but informative 2014 iodine update video by Dr Jorge Flechas:
some points: “why women have so many more thyroid problems eg estrogen blocks iodine; whereas ovary hot nodules may cause thyrotoxicosis from secreting T2. Iodine alerts the brain, so dont take at night! give no more than ~12mg/d ie 2 drops 15% in pregnancy, it stimulates the baby!
“Iodine ie I2 diffuses into cells whereas iodide need to be transported in; babies lack the symporter Iodide transporter, so babies need iodine not iodide.
ie thyroid, ovary and WBCs can make thyroxine- but preferably they mop up low iodine intake. Thyroid supplements doesnt provide enough iodine for needs elsewhere .
” Millions of women in Japan and Korea on their marine diet used to normally ingest ~13.5mg iodine a day, producing very low neonate problem rates in pregnancy and with IQ far higher than average.
“in the west, Iodine has been taken out of bread and milk, and salt intake cut – associated with increased rate of ADD in USA 500% and more cancer thyroid, breast, ovaries, endomet, cretinism, goitre .. – as iodine intake and output in USA has been halved by admin policy…
the kidneys excrete excess ingested iodine, so avoiding overdose from high iodine intake.
“ie if sufficiency, a 50mg iodine load will excrete >90% . so the spot test for low iodine excretion, and 24 hr high iodine excretion, reflect defective sodium symporter problem. This corrects with ongoing iodine supplement. 80% of vegans in USA are iodine deficient due to skipping seaweed for iodine! Asians eat seaweed in everything.. the body can hold 1.5gms iodine; 50mg in the thyroid, 20% in the skin, 30% in muscles…
– if depleted of iodine, we cant sweat or use our muscles (fibromyalgia), brains, or control the breasts or ovaries.. .. just add ATP cofactor ie incl vits B2 & B3 to iodine…
“Bread & esp cooldrink’ iodine (eg Mountain Dew) has been replaced by bromine, which causes schizoid behaviour… .. Iodine reverses the immortality of cancer cells.
” 3000mg/d ester C , and highdose iodine, and B2+B3 , reverse the iodine symporter block, & abolish the fibromyalgia in 80% of sufferers. .
This Flechas review is encouraging for repletion with Lugol’s 50 to 100mg iodine /day ie 6 to 12 drops 15%; after perhaps a precautionary skin test dose for allergy.
especially for protecting breasts, cancer, diabetics, obesity, heart disease, immune, memory and stroke problems.. .
It does seem that as with vits C and D3, iodine has a minimal RDA as far as basic prevention goes ie ~0.15mg – 1mg/d for avoiding cretinism (cf scurvy with >10mg/d vit C, or frank rickets with 400iu/d vit D3) ; and at the other end of the spectrum ie treating severe disease, grams a day of iodine and vit C, and vit D3 >50 000iu ie >1mg/day..
Then longterm maintenance with eg ~12 mg iodine a day ie 2drops/d 15% Lugols, cf 1 to 3 gm a day vit C, vit D3 ~7000iu ~ 0.2mg/day… .
perhaps the corollary may be that , (as with vit D3 eg 2million ie ~ 50mg), a massive accidental load dose eg 2gms iodine- 20ml 15% Lugols- (which apparently bypasses the detox reaction at lower ie buildup dose, and incidentally provides 1gm potassium) may be both harmless and will reload for who knows how many years- presumably provided one takes a good magnesium and selenium ie realfood Banting diet .
To test tolerance, and try to reverse my familial irreversible atrial fibrillation, I have built up my Lugols’ dose so far to 15% 1 to 2 tsp a day ie 4 to 8ml, ~800mg combined (I + I2) iodine with 400mg potassium K a day;
whereas a load dose vit D3 eg 0.6 to a million units (6-10gms of standard max strength 100 cwt powder – with a good magnesium and vit K2 diet as in realfood Banting) will replete safely and harmlessly for less than a year.
Its a pity the simple IODINE urine test is- unlike the skin patch test duration- so tediously long and costly (and both can occasionally mislead),
whereas the blood vit D calcium-creat levels are quick to take but costly tests.. .
But in those who can afford them , the tests are essential to validate the clinical results we get with iodine and vit D3 .
see prev Healthspanlife.wordpress.com ie May 2014 update.
quotes from authorities are in italics: please feed back on errors and experience
Massive iodine deficiency is as universal worldwide (compared to 50 years ago) as are
*deficiencies of: ..vitamin C (except those who live on fresh fruit and veg);
..vitamin D (except those who work outdoors in sunny climes);
..natural saturated fats in all except keen carnivores;
..and increasing deficiency of other vitamins in the food chain, forced on the public by government-sponsored industries and “health authorities” for 50 years now;
*and unnecessary dangerous food-chain toxins ( refined carbohydrates; calcium/bromine/ fluorine/salt, aluminium, mercury supplements, synthetics eg transfats, pesticides eg glyphos Roundup, GMO foodstuffs, antibiotics ; and steroids). .
But with seafood almost wiped out by greed and pollution, and increasing global nuclear pollution, and failure by food producers to supplement iodine never mind vit D and magnesium in the depleted food chain,
iodine repletion with vigorous Lugols iodine (with its consort selenium) is even more of a priority than concomitant vitamin D (with its consort vit K2) and magnesium supplementation, and vitamin C, plus a broad balanced other score A to Z multisupplement ..
So the dangerous scaremongering myths need to be debunked about the “dangers” of iodine at over a mg a day – when the safe general therapeutic dose is not just ~12mg/d but up to 100mg/d for longterm prevention, and over a gm/d for major diseases; ie >10 000 x the RDA. The US recommended adult dose of iodine for nuclear exposure is about 120mg, without any mention of remotest risk of toxicity.
This 1000 x order of magnitude with iodine is like
*the almost 10 000x margin between minimalistic vitamin C 10mg/d dose (RDA now 60mg/d) to avoid scurvy, up to >3v-7gm a day to treat infections, and >30 gm/day (intravenously, or buffered orally) to treat cancer;
*and vitamin D3 (RDA now up to ~800iu/d) up to 250 x more eg from 200iu /d to prevent rickets vs 50 000iu/d to treat some serious diseases, vs 2million iu single doses and 150 000iu/d for decades that have no documentable toxic effects in adults.
Infants obviously need proportionate dosing of all, not left to depend on mother’s milk when she has received no more than the usual prenatal supp folate and iron.. . .
The heaviest essential metal iodine is perhaps the most rare essential mineral – Wiki: “Iodine is rare in the Solar System and Earth’s crust (47th/60th in abundance):”- hence iodine deficiency is universal – especially now it has become fashionable in our lifetime to stop adding iodine to foodstuffs; and instead food manufacturers pump in toxic halides like bromine and fluoride (like dangerous mercury and aluminium in vaccines, aluminium in antacids) that (unlike chlorine, iodine and refined sugars) have no essential biological need and benefit , only risks;
and recognition that commercial pure white runny salt NaCl – overdosing chlorine- is adverse because of worsening hypertension with aging and fast foods, instead of encouraging seasalt. .
The myths have been debunked that
*(unlike our essential blood chlorine in moderation), either fluorine or bromine are essential trace element halogens, any more than commercial cane sugar or fructose are biologically essential in our diet;
*and the Wolff-Chaikoff Effect myths (that iodine is toxic at much more than a mg a day) debunked by Abraham & Brownstein’s review of scientific evidence the past century including Wartofsky, et al 1970 that we overdose with iodine at only 20 x the RDA (0.15mg/d) ie over a mg/ day,
*and the myth that only potass KI /sodium NaI iodides should be supplemented. The most proven iodine is in Lugols iodide providing the balance between KI and free I2.
*Another commercially driven myth is that blood thyroid hormone levels are adequate to diagnose biologically significant iodine sufficiency, and commercial thyroxine to treat patients– the commercial hormones dont address, may worsen the serious iodine deficiency throughout the body that contributes hugely to acute and chronic, common and rare diseases
Studies of traditional Japanese after WW2 showed that their far better cancer-, cardiovascular,- thyroid health (before they emigrated to America, or took up Western diet) was attributable especially to the kelp ie iodine intake in their then-safe seafood diet, giving them an average iodine intake of about 12 mg/day- at least 100 times the current American imposed RDA of 0.15mg/d. But who can trust kelp, seafood from the poisoned oceans and rivers any more?
I recently took for a day each approx 20drops Lugols 2% pd in water ie iodine ~9mg a day; then 15% 4 drops ie 30mg/d …then up to , then 10drops ~70mg/d to test for detox reaction. I carry on with ~50mg/d, as many patients take it . I suppose my lack of detox reaction is not surprising since I have been detoxing for years on about 6 gm a day of a 50 -supp -multiblend( half vit C).- but no more than a mg/d of potass iodide. I find physical and mental stamina better, no longer have angina from stress or walking fast- which I could not do a fortnight before due to angina and fatigue. . .
One shudders to think of the billions of people – especially kids- who are dull, not achieving their full potential for lack of iodine, either because health professionals dont think we need more, or because patients are dismissed as euthyroid based on the usual thyroid lab hormone tests (which ignore iodine deficiency/excess in the majority who dont fall clearly in the over-or underactive blood hormone range).
Conventional western medicine apparently no longer considers or measures iodine deficiency, forgetting that iodine is the primary essential deficient mineral (along with magnesium, selenium, sulphur, phosphate; and iron in kids and reproductive women) for all systems in the body, not just for thyroid hormone levels- which dont reflect iodine security anywhere outside thyroid hormone production by the thyroid. .
Iodine is needed in microgram mcg amounts for the thyroid, milligram mg amounts for breast and other tissues, and therapeutically as anticancer in gram amounts.- Dr. David Miller
The theoretical iodine lethal LD50 for humans ie 1/10th of rodent dose is about 2 gm / kg, eg 6gm for a newborn baby, 140gm for an adult… a bottle of 20ml 2% Lugols in water contains 400mg, a 100ml bottle of 15% in water contains 15gm iodine(ie a 20ml bottle 3g) ie a harmless dose except corrosive if swallowed neat,.
Hence retailers if at all dispense Lugols 2%; we dont lightly prescribe/dispense 15% Lugols except for topical massage. And for cancer and we stick to 20ml dropper bottles.
not even Dischem and Clicks at Cavendish stock Lugols- only 2% iodine tinct IN ALCOHOL ie strictly for burning scratches… so no retailer should sell 100ml of any Lugols prep, only 20ml 2% Lugols, as is enforced in USA. It is indeed apparently regulated in the same way here., ‘tho’ the SA Medicines formulary doesnt mention that (recommends it only preop for eg thyroid storm), nor the multidisease benefits of Lugols including on the brain, wounds, infections, cardiac, vascular, cancer lungs etc;
nor the usual DETOXIFICATION REACTIONS as heavy metals are mobilized, for which (like eg metformin) the Lugol’s dose must be started low and titrated to tolerance with lots of fluids including magnesium, seasalt, selenium , vits B. eg Brief symptoms from heavy metal detox include “headaches, agitation, palpitations, nervousness, the jitters or irritated thyroid symptoms; pimples; skin rashes; fatigue, muscle aches, fever, diarrhea, worsen sinus/asthma, and brain fog. “. http://nourishingplot.com/2014/08/30/detoxing-fluoride-bromine-and-chlorine-naturally/ , http://www.iodine-resource.com/lugols-iodine.html , http://www.tiredthyroid.com/blog/2013/07/15/iodine-protocol-asthma-hives-sulfite-sensitivities/ and http://drsircus.com/medicine/iodine/iodine-and-detoxification. If these heavy metal detox reactions occur, stop the Lugols a few days, increase the detox remedies, then resume Lugols at a lower dose that you dont react to.
Threads indicate that detox problems go away once iodine dose exceeds 50mg/d- especially if taken with a multisupp incl vit C, magnes , BCo, & selenium; and plenty of seasalt in water. (the only one of these not in a multisupplement AntiAging blend is salt).
In perspective, the thyroid holds 50 milligrams of iodine, the breasts hold 200 milligrams, the skin holds 400 milligrams of iodine, and the whole body holds 2,000 milligrams, and possibly much more. Iodine is found and used in every hormonal receptor in the body. in 1911, 900 milligrams 0.9gm/day!) were considered usual and safe dosage. At 6 grams 6,000 milligrams/day!), iodine has been used to cure syphilis, skin lesions, and chronic lung disease. Iodine makes us smarter, helps with mental functioning. Low iodine is associated with low IQ’s with a difference of up to 13.5 points in children; but iodine deficiency is also associated with mental functioning in adults, because iodine not only chelates lead, but, according to Dr. Jorge Flechas, iodine prevents lead from lodging in the body in the first place. Low thyroid function decreases brain circulation, which slows intellectual function. low thyroid function is associated with cognitive impairment, memory loss, depression, slowness of mind, anxiety, suicidal tendencies, and a variety of psychiatric disorders. Bleichrod’s meta-analysis of 17 studies showed iodine sufficiency increases IQ by 13.5 points in children. Iodine prevents heart disease. Iodine is needed with the use of cordless phones, cell phones and now smart meters to prevent hypothyroidism. Iodine decreases insulin needs in diabetics.
IODINE ALLERGY? The risk of iodine allergy is quite low – Drs. Abraham and Brownstein were only able to identify 3 of 4,000 people who had a negative response to the iodine. People do not become allergic to iodine per se, but people react to the displacement of bound heavy metals; and can become allergic to protein-bound iodine as is found in shellfish or to the binding agents, excipients, fillers, preservatives and/or synthetics (rather than the bioavailable form of iodine itself) commonly found in tablets, capsules, and even liquids. Actually, iodine can help eliminate food allergies according to Dr. Derry.
But dont take Lugols at the same time as vit C, which neutralizes the antimicrobial effects of Lugols. so take them at opposite ends of the day.
and because iodine attacks only pathogens and abnormal cells, not our good probiotic biome or healthy cells, it has none of the risks of pesticides , antibiotics, antivirals, radiotherapy, chemotherapy etc.
RESEARCH ON LUGOL’S IODINE?
despite Dr Jean Lugol having published his landmark 1829 work on his iodine complex ie ~185 years ago, there is predictably little research on it published on Pubmed, for the obvious reason that Big Pharma and the Disease Industry and governments wont fund research on such a cheap cure, which would greatly increase survival, but in the short term reduce illness and thus need for health industry workers, hospital beds, pharmacies and new drugs.
There are apparently only three clinically relevant LUGOL’s papers listed on Pubmed ie in the past 50 years:-
from India 2012 Consul ea – confirming that painting the cervix with Lugols (the Schiller test ) and vinegar is as effective as Pap smear for screening; thus combined, the two simple cancer diagnostic paints make up for Lugols iodine for cervix cancer being only about 85% sensitive and specific ie not as reliable alone as a costly lab Pap smear…
Greece 2007 Theodoropoulou ea confirming that preoperative Lugol’s iodine 80mg/d for 15 days in euthyroid people was accompanied by increased intrathyroid total iodine but no changes in intrathyroid hormone HI or demonstrable increases of serum T4 and T3 were observed. It is hypothesized that the maintenance of normal intrathyroidal HI is the result of the combined inhibitory effect of iodine on thyroid hormone synthesis and on the release of T4 and T3 from the thyroid.
Italy 1986 Marani ea –Iodine is therapeutic in various pathologies where immunity plays a dominant role, eg it facilitates cure in tuberculosis, lepromatous, syphilitic and mycotic incl sporotrichosis lesions . This effect does not depend on iodine’s action on the micro-organism responsible, but on host immune boosting. . Iodine may also be used in Panniculitis, in erythema nodosum, in nodular vasculitis, erythema multiforme etc. . To establish relationship between dietary iodine and immune response, 607 infants in an area of endemic goitre were studied: 215 were given Lugol solution (2 drops- presumably 20mg? a week for about 8 months ; and 392 not. Immune response was assessed by the skin test tetanus toxoid (in the U.S. 80% of paediatric cases aged 2-10 years old were positive). A significant difference was noted in the average diameter of the infiltrations after the tetanus toxoid skin test in the two groups considered (P less than 0.001). The results indicate that an adequate iodine intake is necessary for normal retarded immune response – a fact that the disease industry and Big Pharma blatantly ignore. . . (Iodine does not have the adverse effect of antibiotics on our gut biome, or causing antibiotic-resistant pathogens)
But there are dozens of scientific Lugol’s studies not referenced by Pubmed:
The End of Antibiotics and the Rise of Iodine as an Effective Alternative 2008 Mark Sircus
Iodine and viral infection?
David Derry, MD, PhD Thyroid Science 2009 Iodine: the Forgotten Weapon Against Influenza Viruses
Mamo & Naissides International Journal of Infectious Diseases (2005) from Australia show Iodine Could be effective in the treatment of human immunodeficiency virus and AIDS-associated opportunistic infections. as it is in rodents and cats .
Inactivation of human immunodeficiency virus by iodine-releasing products Harbison & Hammer Boston, Massachusetts 1989 showed that “povidine-iodine completely inactivated HIV at concentrations of greater than or equal to 0.5% ie is highly effective at killing HIV.
Betadine is simply “a stable complex of povidone and elemental iodine, contains 9.0% to 12.0% available iodine ie 90-120mg/ml .. Free iodine slowly liberated from the povidone-iodine PVPI solution kills microbe (but not healthy mammalian) cells through iodination of lipids and oxidation of cytoplasmic and membrane compounds, thus exhibits a broad range of microbicidal activity against bacteria fungi protozoa and viruses. Slow release of iodine from the PVPI complex in solution minimizes iodine toxicity towards mammal cells.” This compares exactly with a similar iodine complex 15% Lugols which contains about 10% ie 100mg iodine /ml water .. at far lower cost than but identical safety and efficacy to the patented Betadine – a modern designer marketable patented crib of Lugol’s .. …
and IODINE, A CRITICAL NUTRIENT 2014 http://drlwilson.com/Articles/IODINE.htm
Iodine: Its Role In Health and Disease: New Exciting Concepts Michael B. Schachter, M.D. 2007: Guy Abraham MD, former professor of obsts gyne & endocrinology at UCLA School of Medicine, has written papers about iodine that drastically changed my thinking about its role in health and the prevention and treatment of disease. I had been impressed by Dr. Abraham’s previous work, which showed that vitamin B6 and magnesium could be very helpful to women with premenstrual syndrome (PMS) and was eager to learn what he had to say about iodine. Through a series of articles termed “The Iodine Project,” Dr. Abraham proposed that the optimal daily dose of iodine for a WELL person is approximately 12.5 mg, which is 100 times the RDA of 0.125 mg, ie that the current prevailing medical opinion that more than 2 mg a day of iodine is toxic is wrong. He traces the source of this major blunder to a scientific experiment on rats that was published in 1948 by Drs. Wolff and Chaikoff, which erroneously concluded that iodine inhibits the thyroid gland at doses of about 20 times the recommended daily allowance (RDA) for iodine. This conclusion was later generalized to humans and can be found in medical textbooks, including endocrinology and nutrition textbooks. Guy Abraham wrote in 2005: In hypertension, iodine sufficiency resulted in normalization of blood pressure without medications; as reported by other physicians using this program. Best results were achieved when orthoiodosupplementation was combined with a complete nutritional program emphasizing magnesium instead of calcium. Obesity increases the requirement for iodine and up to 100 mg elemental iodine/day may be required to achieve and maintain sufficiency. Increased demand for iodine occurs with excessive amounts of goitrogens from the diet and lifestyle. eg, smoking increases serum thiocyanate levels, interfering with the sodium/iodide supporter function. Low thyroid iodine is associated with thyroid hyperplasia and cancer. Could thyroid hormones cause the same iodine depletion in breast tissue? The prevalence of breast cancer is higher in women on thyroid hormones. Medical iodophobia resulted in removal of iodate from bread 20 years ago, replacing it with the goitrogen bromate- which associated with increased obesity, diabetes, and hypertension, thyroid and breast cancer. Recent reports show association between low iodine intake in women during pregnancy and attention deficit and hyperactivity disorder (ADHD) in their offspring. The most plausible explanation is a decreased sensitivity of the nuclear thyroid hormone receptor to thyroid hormones. We previously reported evidence for improved receptor response to thyroid hormones following iodosupplementation. Therefore, iodine is not only necessary for the synthesis of thyroid hormones but also for their effect on target cells. This effect is probably due to iodination of the thyroid hormone receptor. The essential element iodine, which is the inorganic, non-radioactive forms, deserves more attention from researchers and clinicians. It maybe the missing link in patients currently resistant to conventional hormonal therapy.
re adding enough selenium, chromium, vit C, Magnesium, Vitamin B2/3
Until 2007, in the United States, Lugol’s solution was unregulated and available over the counter as a general reagent, an antiseptic, a preservative, or as a medicament for human or veterinary application .
However, effective August 1, 2007, the DEA now regulates Lugol’s solution (and, in fact, all iodine solutions containing greater than 2.2% iodine) as a List I precursor because it may potentially be used in the illicit production of methamphetamine. However, transactions of up to one fluid ounce (30 ml) of Lugol’s solution are exempt from this regulation. When buying Lugol’s Solution on places like Amazon, most sellers fail to indicate the DEA tracking requirement. On the other hand Lugol’s Iodine solution is available over the counter in Canada and Mexico.
Toxicity Because it contains free iodine, Lugol’s solution at 2% or 5% concentration without dilution is irritating and destructive to mucosa, such as the lining of the esophagus and stomach.
Doses of 10 mL of 5% solution have been reported to cause gastric lesions when used in endoscopy. The LD50 for Iodine is 14,000 mg/kg [Rat] and 22,000 mg/kg [Mouse].
Most guidelines accept that anything with an LD50 >2 g/kg (-5 g/kg in some countries) can be classed as having a low acute toxicity which classifies Iodine as having low toxicity. Potassium Iodide is not considered hazardous.[15
Treatment of Influenza and other Diseases iodine-dosages 2009 “After testing over 500 patients, I found that 94.7% of my patients are deficient in inorganic iodine. Dr. David Brownstein In this chapter I will present different views and practices from present as well as from the long past when iodine was vastly more popular as a medicine than it is today. For whatever irrational reason, doctors and patients fear iodine thus en mass do not use to its fullest potential.
Humans tolerate large doses of iodine but the ultra high doses that were used many decades ago are not required to get the most out of iodine therapy. Just a little goes a long way, as the governmental iodized salt programs showed but this dosage level was only effective for Goiter and its avoidance. It actually takes very little iodine to prevent this disease but no one ever said that was the only purpose and need for iodine in the body. Today people are more deficient then ever before because our need for iodine has increased in direct proportion to our toxic burdens especially of other competing halogens. Read on at http://drsircus.com/medicine/iodine/iodine-dosages
see lugols_dosage_chart. . But for obvious reasons stick to 2% till you know you tolerate and need much stronger drops.
firstname.lastname@example.org Cape Town
update 24 Feb 2914 Todays JAMA on-line- first prerelease article about the current resurgence of Critically Ill Patients With Influenza A(H1N1)pdm09 Virus Infection in 2014 laments its high deathrate from acute respiratory and multiorgan failure adults in young adults, and its guarded response to antiviral designer drugs like Tamiflu. But it fails to mention vitamins and minerals, although these have dramatic benefit in both preventing infections, and treating flu, AIDS and TB.
Flu season: Vitamin D versus H1N1 Flu , Hormones Matter and Vit C cures H1N1 highlight the safety and efficacy of vigorous vitamin D & C repletion, never mind when combined with other antimicrobial supplements like the other vitamins, and the minerals selenium, zinc, iron, iodine, and antimicrobial plant extracts like sutherlandia and galega officinalis etc.
Guess which Big Pharma is the biggest manufacturer of vitamins in the world? Roche. and guess which company makes Tamiflu? Roche– which refused to release the data from all of its trials, the adverse effects far exceeding its benefits.
But nutritional supplements are not patentable, so they are studiously ignored by the Disease Industry for whom only profit matters.
More about the lethal effect of deriding and suppressing good remedies under the-2014-virus-season-dawns-avoiding-the-semmelweis-reflex-natural-antibiotics-vitamins-c-d3-avoiding-vitamin-denialism – The Semmelweis Reflex.
update 16 Feb 2014: it’s taken 5 years, but at last the fraud of Big Pharma and the Regulators, Governments they support is being exposed in more depth:
the Swine Flu pandemic of 2009- set up by the Vaccine Industry paying vast bribes to world Regulators and Governments- to promote the useless if not risky flu vaccine and Tamiflu drugs, is being confirmed and investigated, as reported by www.NaturalNews.com email newsletter: Even the science journals are now investigating the total scam of the WHO’s flu pandemic fear mongering. Here’s what you need to know: http://www.naturalnews.com/043932_Big_Pharma_World_Health_Organization_flu_scam.html
and the wider Multiple Vaccine MMR fraud affecting especially infants and children (the gastroenteropathy- Autism link), that has been centre stage for 15 years, is analysed in detail by Dr Andrew Wakefield in his new book Callous Disregard.
Update 15 January 2010: current commentaries: Mary email@example.com is quoted as writing:
INQUIRIES GET UNDERWAY INTO CONFLICTS OF INTEREST Governments heeded warnings from the United Nations that there would be millions of deaths unless nations promptly proceeded with the controversial vaccination plan promoted by the UN’s entity for health matters, the WHO. With billions of dollars of unneeded inventory now going to waste, government leaders turned angry and started to demand hard answers.
Articles in the European press have repeatedly called into question the myriad ties between vaccine manufacturers and decision makers in the WHO.
The French opposition Socialist Party described that country’s national campaign as an “extravagant fiasco” and demanded a parliamentary investigation.
In early January 2010, the Council of Europe member states announced they are launching an inquiry into the influence of the pharmaceutical companies on the global swine flu campaign, focusing especially on extent of the drug industry’s influence on WHO. The text of the resolution says, in part, “In order to promote their patented drugs and vaccines against flu, pharmaceutical companies influenced scientists and official agencies, responsible for public health standards, to alarm governments worldwide and make them squander tight health resources for inefficient vaccine strategies and needlessly expose millions of healthy people to the risk of an unknown amount of side-effects of insufficiently tested vaccines. The ‘bird-flu’-campaign (2005/06) combined with the ‘swine-flu’-campaign seem to have caused a great deal of damage not only to some vaccinated patients and to public health-budgets, but to the credibility and accountability of important international health-agencies.”
The WHO’s “false pandemic” flu campaign is “one of the greatest medicine scandals of the century,” according to Dr. Wolfgang Wodarg, Chairman of the Parliamentary Assembly of the Council of Europe. “The definition of an alarming pandemic must not be under the influence of drug-sellers,” he adds.
Wodarg, a doctor and former SPD member of the German Bundestag, says that the “false pandemic” campaign began last May in Mexico City, when a hundred or so “normal” reported influenza cases were declared to be the beginning of a threatening new pandemic, although there was little scientific evidence for this. Nevertheless the WHO, “in cooperation with some big pharmaceutical companies and their scientists, re-defined pandemics,” removing the statement that “an enormous amount of people have contracted the illness or died” from its existing definition and replacing it by stating simply that there has to be a virus, spreading beyond borders and to which people have no immunity.
These new standards forced politicians in most states to react immediately and sign marketing commitments for additional and new vaccines against swine flu, through “sealed contracts” under which orders are secured in advance and governments take almost all responsibility. “In this way, the producers of vaccines are sure of enormous gains without having any financial risks. So they just wait until WHO says ‘pandemic’ and activate the contracts,” says Dr. Wodarg.
The Japanese health ministry announced it is launching an inquiry into deaths and side effects from the vaccine. Japan recorded 104 deaths, roughly 80 percent of whom are people aged 70 or older who had chronic diseases or disorders. Additionally, some 1,900 cases of side effects had been reported from medical institutions.
In the U.S., President Obama had decreed the H1N1 pandemic a national emergency, prompting some analysts to warn about increased governmental powers. The U.S. Department of Health and Human Services had issued a “formal declaration of a Public Health Emergency” in April of 2009, even though there had only been 20 confirmed cases of the H1N1 virus.
To date, the U.S. has not followed in the footsteps of the Council of Europe.
William Campbell Douglass II, M.D. writes:
How Big Pharma profits off fear With Big Pharma raking in billions off swine flu fears, the last thing they need is a government handout.
Yet Uncle Sam is busy playing Daddy Warbucks with YOUR lunch money, helping Swiss drugmaker Novartis open a new vaccine plant in North Carolina. You’ve generously contributed around $700 million to help Novartis build their shiny new drug factory — $220 million three years ago, and $486 million this year.
And I’ll bet you didn’t even get a thank-you card.
In return for this bad investment in a foreign company, the U.S. government gets the right to PURCHASE vaccine for 17 years. Not only that, but these vaccines will be created using a new and unproven biotech method that relies on dog kidneys instead of chicken eggs.
In other words, this plan really is a dog.
I’m a doctor, not an economist. But if this is someone’s idea of stimulus, you do the math: The plant now employs 191 people making an average of $50,000 per year. At that rate, it would take around 75 years for the government money put into this joint to make its way back into our own economy.
Slice off a few years if you believe them when they say they’ll ultimately employ 350 people when the plant is fully operational in 2013 — in any case, it’ll be decades before Americans ever see that cash again.
But don’t worry — I’m sure somewhere, a poor Swiss ski resort is hosting a group of free-spending Novartis executives.
Maybe they’ll be joined by their yodeling friends at the World Health Organization. A report at World Net Daily says at least three of the WHO’s top flu “experts” have financial ties to vaccine makers.
That sure explains a lot.
Meanwhile, anyone who doubts that money is the real driving force behind swine flu fears only needs to check out Business Week magazine.
A recent headline there tells whole story by itself: “How Big Pharma Profits from Swine Flu.”
Careful there, Business Week. That kind of thinking would have gotten you branded a radical conspiracy theorist just a few months ago!
Just check out these big paydays off swine flu vaccine sales:
• $1.7 billion for GlaxoSmithKline
• $700 million for Novartis
• $500 million for Sanofi-Aventis
Those figures are for the fourth quarter of 2009 alone — analysts expect them to grab similar piles of cash for the first quarter of 2010 as everyone from President Obama to Santa Claus push these needless vaccines on you and your children.
Business Week also notes that vaccine sales are booming just in time: Patents on prescription drugs worth a combined $135 billion in annual sales are about to expire… with no new meds ready to replace them.
And that means you can expect another phony swine flu scare any moment now.
Never feeding the flu fears”.
These need to be read in tandem with the other vaccine sagas:
Martin Walker’s ongoing expose of The Drug Industry-GMC-NHS vendetta against Dr Andrew Wakefield for daring to question the benefits of mass vaccination of infants;
about the risks versus benefit of vaccinating pubertal boys and girls against cervix cancer;
and the mad search for an HIV vaccine against a disease which is in fact a sociological problem of nutritional immunodeficiency upon which is superimposed sexual violence as in rape or voluntary recklessness usually against (usually) innocent partners – promiscuity in multiple concurrent sexual relationships as currently promoted by sexual predators like Tiger Woods and the illegitimate and corrupt South African “president” Jacob Zuma. .
UPDATE 16 December:
It is now 15 weeks since this column expressed grave doubt about the cost-benefit of the touted anti-virals Tamiflu and Relenza .
All hell has broken loose over drug company fraud- which could only have happened in collusion with big politicians:
not only has proven swine flu mercifully fallen far below pandemic deathrate and sickness predictions, while big batches of vaccine (GSK) have had to be pulled due to serious complications even in Canada- and GSK directors /promoters too are under scrutiny;
but predictions about the fraud of massive anti-influenza drug promotion have proven all too true. The BMJ today is full of doubts since a solitary Japanese author questioned the veracity of selectively published let alone unpublished Tamiflu studies orchestrated by Roche.
As some say, in marketing and disease-mongering, its like in love and war- anything goes – and provided it promotes American corporate interests, the FDA goes along.. ..
20091111 A This WW1 Armistice day : A new report quotes the CDC projection that “4000 rather than 1200 Americans have died of swine flu since April.. and that the University of Minnesota Center for Infectious Disease Research thinks deaths are likely to be in the 30,000-to-40,000 range, and would have a long way to go to even get there… The vaccine should also cut the death rate.”.
Yesterday an appeal from the FDA Commissioner of Food and Drugs went out to all to promote the swine flu vaccine. But Dr Hamburg does not quote one iota of evidence that the vaccine does or will do more good than harm- especially in those at highest risk, the pregnant, the old and ill and infants. She fails to address the cardinal issue: why have no trials so far assessed the benefit of the vaccine (on swine flu infectivity and morbidity) against placebo on a background of well-known anti-infective natural safe supplements?
It is perfectly obvious that with an apparent infectivity rate of swine flu well above 1:1000, but an apparent linked mortality rate of 2 per million of population per month through September-October- the USA- the FDA CDC and the other interlinked countries at highest risk- Canada, Australia, UK, Brazil, Argentine – had a duty to see that the vaccines were immediately tested in double-blind RCTs against placebo injection in volunteers– at least the apparently moderate risk ie the well young, but most of all in the high-risk groups ie the age extremes, pregnancy and those with serious chronic diseases.
From the already established spread-, fatality- and complication rate, it is obvious that, during the current upsurge reported by these countries, it would take no more than a few weeks – at a vaccination rate even in Sweden of 2million people in a few weeks, with spread rate of thousands of new tested cases a month, to produce the crucial answers- how far does the vaccine cut the infection rate, and the morbidity rate and degree.
Yet according to the NIH Clinical trials.gov registry, there is still no such trial listed. The FDA decided it doesnt require efficacy data on the vaccines.
So it appears that the Authorities in all pandemic countries are guilty of gross deception- at best that they know that the vaccine is pretty useless, or worse, that they dont know – and don’t want to know till the vaccine is all used up. Dastardly conspiracy theorizing, by sober scientists, but that’s what the Authorities’ declared deliberate omission (evasion of such a basic obvious efficacy trial) creates.
At least there is a double-blind placebo-controlled clinical trial of Tamiflu in progress in Hong Kong, in 300 patients with the swine flu, lasting a year. . The outcome is likely to be that, if tamiflu doesnt prove to be worse than the placebo, 300 is far too few subjects to show any significant benefit over placebo.
Bloombergs reports today that Norway has had 6300 confirmed cases by last week and 16 related deaths by Nov 9, but while Sweden had cases doubling weekly to the last week of October, there have still been only 3 related deaths reported . However on Nov 9th perhaps the 4th related death was reported in Sweden. . But Sweden has banned media reporting on swine flu vaccine deaths, which stood at 5 after 2million vaccinations.
It looks like the cumulative swine-flu related deathrate in Europe has reached 0.8 per million population.
20091109 The past week: only one new case has been reported in Southern Africa (Namibia) and no linked deaths in Africa; in Canada between 3-5 Nov there were 14 new linked deaths (14% increase); in Netherlands 7 people died in the week to 6 Nov, with the total there still only around 20 attributed to the swine flu.
The USA latest CDC report shows that in the 2 months to end October influenza-associated death rate was 2 per million of population per month; for comparison, in 2006 the monthly deathrate was 770 per million, of which influenza and pneumonia contributed only 2.3%, the 8th leading cause after cardiac-, stroke, malignant, lower respiratory, accident, diabetes and alzheimer causes. Since – accidents aside- all of these commonest fatal diseases are precisely the highrisk patients that die most of influenza anyway, it is unclear whether the present increase in ILS ( influenza-like syndrome) deaths has significantly increased overall mortality
SWINE FLU 1918: There is a graphic interview on November 5th with a living survivor of the 1918 genuine flu epidemic, which killed some 2.5-3% ie 25 000 of every million people (5% in India) by blue death- drowning- in at least America, France and Germany, far more in India. That H1N1 plague lasted at least 2 years, infecting perhaps 1/3 of the world population of 1.5billion, with 50% cross-infection rate and mortality rate of between 2% and 20% of those infected.
SWINE FLU 1976: that outbreak never spread beyond Fort Dix, where one victim died. But in the ensuing government panic, 22% of the population were given a hastily prepared vaccine, followed by 1098 cases of Guillaine-Barre syndrome, at least half of which were attributed to the H1N1 vaccine, with at least 25 deaths. A recent review puts this risk (of GBS after H1N1 vaccination) at about 1 in a million- far higher than there is now of healthy people dying of the current swine flu outside the Americas and Australia.
SWINE FLU 2009: it is cold comfort to see the current swine flu global picture on Wiki at the end of October- a true deathrate of probably <1 per million after at least 6 months. The big question is, will there be more waves of it or, worse, a deadlier mutation caused by hasty vaccination?
The biggest question, mystery, now is: if swine flu is indeed pandemic and spreading at least in America and Australia, why are there still no placebo-controlled trials published confirming that the vaccines and antiviral drugs reduce infectivity, severity and mortality of the 2009 H1N1 virus?
INCIDENCE: While bigger countries have stopped testing all but key or high-risk suspect cases for swine flu, the smaller countries’ figures of confirmed cases relative to population size are instructive:
closed communities like the Cook Islands, Hong Kong and Macau respectively found incidence of 0.9% – 0.47%;
but only 0.07 -0.25% in other “ islands” world wide – Caymans, New Zealand, Jersey, Bahrain, Iceland, Marshall, Australia, Malta.
Mainland countries that apparently continue screening all who report in with flu symptoms – like Portugal and Belgium -found respectively 0.24% and 0.08% of suspects positive for swine flu.
FATALITY: As regards death rates: Mexico and South Africa reported apparently related deaths among confirmed swine flu cases as approx 0.7%/1000 infections ; Australia & Japan approx 0.5%; Hong Kong 0.12%; and Germany and Portugal approx 0.02%.
Multiplying the incidence rate by the case fatality rate- or more simply dividing the number of deaths by the population- suggests that if you the reader are generally well, the odds of your dying of swine flu are far below 1 in a million; whereas infants, or the elderly, the chronically ill or the obese are at far higher risk of dying anyway. So far there have been some 1500 deaths in 308million Americans recorded in people testing positive for swine flu- that, is some 5 deaths per million- but by epidemiological reasoning by an international team, most of those deaths were already in pregnant or other (chronically) high risk patients and therefore not attributable primarily to the swine flu itself- they were already, knowingly or not, at high background risk..
1500 deaths in 6 months in America is ~0.8 deaths per million per month, but the background- all-cause death rate there averages about 68 per million per month by last CDC count.
Japan and India with the highest population density in the world for big developed populations are remarkable – since the first case in their spring 6 months ago, similar population deathrates so far of only 0.00004% or 0.4 per million.
whereas in USA the official attributed swine flu death rate so far is 12 fold higher ie about 0.0005% ie 5 per million. North America’s epidemic had only a month headstart on the rest of the world.
These fatality rates may be the maximum theoretically, since even in these first-world countries, the great majority of those who did have swine flu symptoms would not have reported in to be tested.
While most cases of swine flu would have been unrecorded- shrugged off- in both developed and poor countries it is likely that many deaths at the time of maximum scare may have been wrongly ascribed to swine flu. This is what the naysayers about deaths after vaccination (whether against eg HPV- cervix cancer or against swine flu) are arguing strongly- that with mass vaccination superimposed on normal deathrates, the deaths within a few hours of vaccination or within days of flu are simply co-incidence, they are unrelated to the co-incidental vaccination or the flu….
In Canada, “The majority of suspect swine flu patients— over 85% (in intensive care) — have some associated medical risk factors.”
The current NICD stats for South Africa show that 77% of those who died with swine flu had relevant co-morbidity – 50% had HIV, 28% were peripartum women, 21% were obese, 11% diabetic, and 9 to 11% had active TB and/or serious cardiac disease. 91deaths is 1.8deaths per million – surprisingly low in the most unequal and reckless population in the world with massive overweight and ischemic heart disease; the poor great majority having been increasingly deprived of jobs, education and quality health care, and suffering the highest AIDs, tuberculosis, infantile and maternal mortality rates, due to criminally negligent government since ‘independence’ 15years ago which has left the majority increasingly worse off.
So while the 2009 swine flu infectivity the world over is probably far above 1%, the fatality rates causally related to the flu virus in those who contracted the swine flu in developed prosperous northern countries (eg Europe, USA, Canada, Japan) was surely well below 0.03% ie <3:10 000; and in poor countries like RSA and Mexico and India, probably similar since the virus would have spread far more densely in crowded poor communities with higher malnutrition and underlying common diseases- but more protected by having already survived poverty-related infections but also having less robust immune response.
It remains a mystery of rational reasoning as to how the wildfire spread of the 2009 H1N1 virus, and the low linked case fatality rates, justify the promotion by first-world countries of ‘pandemic’ panic and mass treatment with untested vaccines and risky antivirals- especially when the vaccines contain notoriously risky adjuvants like mercury, aluminium and squalene, let alone extracts (and possibly prions) from species other than humans. These countries seem to have learned nothing from experience the past century with influenza, polio and HIV.
The reasons may be simply economic- Only Disease Pays, it’s a huge boost for healthcare providers, and manufacturers of “antiviral” drugs, test kits, anti-swine flu vaccines, masks, disinfectants etc.
Why are there such differences in reported swine flu deathrates in similar countries?
Examining regions in the ~ 6 months since the the pandemic hit them:
EUROPE: the biggest nation- Germany with 80million people has had 20 000 people test positive ie 1 in 40 000, with 9 deaths ie about 0.1 in a million of population.
AlpineSwitzerland with almost 8million people has tested all suspicious cases with only 1000 confirmed swine flu, and no suspected deaths – but it has banned the Glaxo vaccine Pandemrix from being used in pregnant women, children or young adults (below 18 years of age) or elderly (above 60 years of age).
Scandanavia: In Sweden this Glaxo vaccine has already been associated with 5 deaths in the first 2 weeks – 5 deaths per (2) million population vaccinated in a month -with only some 2000 flu cases documented. Yet so far in 6 months only 3 -4 deaths there – 0.3 -o.4 per million population- have been associated with swine flu itself . If 5 deaths there soon after the swine flu vaccine , out of (2) million people vaccinated in less than a month, are co-incidental- a vaccine-related death rate of 1:200 000. – one can equally argue that 4 deaths with the swine flu in a month in a population of 9.2 million is not a causal relationship but co-incidence of death from other causes and not from the passing mild swine flu.. Norway has had 15 deaths ie 3/million; but Finland only 0.4 and Denmark only 0.16 per million. These and Switzerland are all cold countries with some 33million total population, 22deaths representing a fatality rate of 0.66 per million- the same as the average for Europe. Can there be such significant difference in prosperity and social services accross the EU to explain the vastly different death rates? Or is it just statistical vagary, or the fault of sensationalist disease-mongering media?
A warmer but still cool country like Germany has a swine flu deathrate of only 0.1/million, whereas the warmer British Isles have a rate of 2.5/million. And the four Greko-Latin European nations vary from 0.5 in Portugal & Greece to 1.1 in Spain to 4/million in Italy. Why the 8 fold difference? they all take plenty of wine, olive products and a Mediterranean diet; and many citizens travel widely between these old countries and their migrant kith and kin at the fountainhead of swine flu in North America. .
The overall European swine flu deathrate is only 0.78/million, with France – stretching from the Alps to two warmer major oceans – similar, and the Low Countries only 0.5.. Why deathrates in three prosperous countries genetically so linked to the rest of Europe but climatically so diverse as Norway, Italy and UK are so much above the rest of Europe remains to be unraveled.
CONTINENTAL DIFFERENCES: in poor South America there are also wide differences with 1.5 / million in Argentine but 7 per million in Brazil and the whole continent, compared to 3 per million in the colder North America; 4/million in the warmer Caribbean; and 9/million in Australasia. Why should deathrates be the high in the Americas and Australasia, but 90% lower in Japan, India and most of Europe?
But presumably the bigger and poorer the population, the fewer swine flu deaths get reported, tested and attributed- this may apply equally in Southern Africa, as in India, China and Russia.
Despite the vastly different climate conditions under which the majority of their people lives, the American deathrate so far – 5/million- is 25% higher than in Canada and poor Mexico‘s 4/million. But the USA admits that most cases of virus-like pneumonia are no longer being tested for H1N1, there are assumed to be due to it. Yet some sources say that this assumption grossly overestimates the actual swine flu.
COMPARISON WITH AIDS: while the flu also knows no social barriers- it merely spreads faster and bites faster in denser and more vulnerable poor populations- AIDS remains largely a scourge of ignorance, violence (male) and recklessness(male)- especially amongst politicians, who are amongst the most promiscuous people globally, but eg in South Africa also the cruelest in deliberately depriving the population until very recently of both a semblance of social security and antiretrovirals, while spending the abundance of tax revenue on corrupt profligacy – in unneeded weaponry, and personal luxuries like mansions and (to this day) German limos.
Hence the prevalence rate of AIDS varies from above 15% in Southern Africa ( antenatal HIV prevalence of 30%) to between o.1 and 1% in the rest of the world; with mortality varying from 50% within a year of clinical presentation in the malnourished squatter millions without treatment, to 50% survival after 20years with decent living standard and ARVs etc. In South Africa this year AIDS is said to kill a thousand a day ie 20 per million of population every day ie 7200 per million (7.2% of the population) per year- against a crude birthrate of 2% giving a nett population decrease of 5.2% a year, reducing life expectancy at birth to only 49years .
THE VACCINE SAGA: MORE DECEPTION WITH MISLEADING TRIAL RESULTS :
HIV-AIDS VACCINE: after >30years there is still no proven safe relevant vaccine in sight against the HIV. But if rape and male reckless promiscuity were stopped, there would be no need for a vaccine since cross-infection is so easily avoided.
SWINE FLU VACCINE: Since there has been no trial published of the clinical benefit of the flu vaccine, no objective information whatsoever is available to judge it’s efficacy versus risk in swine flu prevention. No significant double-blind trial has been done offering the flu vaccine versus placebo injection. The first uncontrolled apparently open trial started in Australia 22 July, with results promised and delivered within 6 weeks ie 2 months ago. It is strange indeed that just 8 weeks after the start of that trial, the Australian govt approved the vaccination campaign. . A medical media report of 11 Sept says only 240 people were enrolled in the trial, age 18 to 64 years ie outside the peak risk agegroups at the extremes of life; and the only result released was that the subjects had a good antibody response.
Even the NEJM official trial report gives no clinical results as to protection- although the New York Times got it wrong in reporting that the “convincing trial showed robust protection” . This conclusion is hysterical nonsense since the only data reported was the antibody response, which does not mean there will necessarily be any clinical protection against the swine flu. There can be no conclusion as to whether the vaccine reduced the swine flu infection rate or severity because there was no placebo group, double blind or otherwise. Similarly, the Australian trial in children 10 to 17 years old, the Spanish trial in toddlers, the USA trial in pregnancy, and the Chinese trial, showed good antibody response by 10 days – but gave no result about clinical protection.
So all we need is a simple 2 x 2 RCT of flu vaccine versus placebo vaccine, with all cases independently covered by eg a supplement of zinc plus highdose vitamin betacarotene + C + D + K plus fish oil as baseline safety net, or placebo. The most important question remains: given the huge proven benefit of safe vigorous doses of these cheap freely available supplements against both flu and AIDS, do people need anything more than a multisupplement to reduce risk of all diseases? and does adding a costly hazardous H1N1 vaccine on top of that give worthwhile better protection against swine flu? The answer must be overwhelmingly NO, given the risk of at least GBS if not anaphylactic death after H1N1 vaccines. Why take a vaccine if it’s risk is far worse than that of the swine flu itself, let alone simple all-system multinutrient prevention that reduces all-cause mortality by at least a third?
But the last thing that vaccine manufacturers, marketeers and governments want is a negative answer, so they dont allow such a trial- is it because they lack courage, or that they already know the answer is negative, or worst of all, that the vaccine is worse than useless?
Some may argue that it is unethical to offer nothing ie double placebo in such an RCT with rare but arguably serious virus-related complications. So all could be covered by at least a simple standard multivite a day at below RDA levels- which by all accounts gives marginal if any benefits except in the malnourished.
Obviously the difficulty with such a virus trial is cost and invasiveness: in an RCT of the vaccine, one ideally needs to have both serological and culture screening for this hybrid H1N1 virus at baseline – as well as placebo-controlled evidence of reduction in disease. Since the swine flu is so far milder than seasonal flu, there is no other way of defining whether a specific swine flu vaccine is of significant overall benefit against this H1N1 virus.
Trumpeting “pandemic” and compulsory vaccination with an unproven vaccine is a great distraction and profiteering for governments- presidents and the Big Business that controls them and their agencies, beset with insoluble political and corruption scandals as are most. Recently an Australian anti-vaccination group published a damning cross-referenced litany of evidence against the trillion$ vaccination industry.
The current “pandemic” distraction with swine flu while they wage war on their peoples, effective martial law implemented or foreseen in the USA, China, and South Africa (predicted conversion of the police to a massive politicized paramilitary, nationalization of all major industry and business and provincial governments), is beyond the imagination of most fiction writers except masters like Margaret Atwood – ‘The Handmaid’s Tale’; Jose Saramago – ‘Blindness’ and ‘Seeing’; Gabriel Garcia Marquez ; Franz Kafka. .
We can only continue to pray, hope that sanity will prevail , that RCTs of both the swine flu vaccine and antiviral drugs are being done to prove that they are both useful, necessary and safe. There is no evidence on the internet of this, suggesting that conspiracy theory may prove correct – that the whole vaccination and antiviral drugs if not the severity of the ‘pandemic’ are simply the result of disease-mongering for profit, like ever-popular war-mongering on every continent..
update 22/3/2014: the March equinox:Vaccines and antivirals for preventing and treating influenza in healthy adults have very modest benefit. as the seasonal flu epidemic wanes in the northern hemisphere and approaches in the south, Authorities eg the US CDC continue relentlessly to promote mass flu vaccination. The South African Authority NICD recommends vaccination for anyone at high risk ie the elderly, infants or the sick, and carers. It also recommends antivirals eg Tamiflu for infection- but the BMJ recently publishes Study claiming Tamiflu saved lives was based on “flawed” analysis. a 2012 BMJ report by the samemedical journalist Zosia Kmietowicz notes Cochrane group rejects Roche’s offer of “advisory board” to discuss analysis of oseltamivir data. The 2011 Cochrane question remains unresolved: Does Oseltamivir Tamiflu Really Reduce Complications of Influenza?
But current Cochrane review of controlled trial publications to 2013 confirms “Vaccination of pregnant women is recommended internationally, while healthy adults are targeted in North America. The overall efficacy of inactivated vaccines in preventing confirmed influenza has a NNV of 71 (95% CI 64 to 80). . Live aerosol vaccines have an overall effectiveness corresponding to a NNV 46 (95% CI 29 to 115). Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates. Inactivated vaccines caused local harms. CONCLUSIONS: Influenza vaccines have a very modest effect in reducing influenza symptoms and working days lost in the general population, including pregnant women. This review includes 90 studies, 24 of which (26.7%) were funded totally or partially by industry. Out of the 48 RCTs, 17 were industry-funded (35.4%).
A current German review Methodological quality of systematic reviews on influenza vaccination. Fourty-six systematic reviews fulfilled the inclusion criteria. Average methodological quality was high but variability was large (AMSTAR range: 0-11). Quality did not differ significantly according to vaccination target group. Cochrane reviews had higher methodological quality than non-Cochrane reviews (p=0.001). this was due to better study selection and data extraction, inclusion of unpublished studies, and better reporting of study characteristics (all p<0.05).
Abstract: The Semmelweis Reflex is about rejecting, deriding important new scientific discoveries or any serious sincere statement/action. I didnt fully appreciate the importance of that age-old human (mostly male) evil – mocking, martyrdom and murder by denialism- until I started this review of the current flu season threat and the role of supplements, and researched pioneer medical martyrs Drs Ignaz Semmelweis, Jack Drummond and Linus Pauling as paradigms of the scourge of modern vested-interest denialism and falsehoods, in medicine as much as politics, religion etc..
In fact, just as it is negligence to deny (as Semmelweis’s persecutors did) gloving up or properly washing hands between examining patients , or ensure that every adult has bloodpressure checked occasionally, it is clearly bad practice not to ensure that everyone – especially the young and old, takes a multinutrient plus extra vigorous dose vitamins D3 and C, plus some protective herbs- garlic, cinnamon, ginger, origanum; and fish oil and/or coconut oil if not both; and drastically cut down sweetness intake- especially fructose, sucrose and aspartame that now pervade all mass- produced food and drinks..
update 21 January 2014 : URGENT: THE 2014 FLU EPIDEMIC: “High H1N1 prevalence and mortality rates a concern: Type A (H1N1) influenza, the commonest flu virus in Canada this year, has a higher than anticipated mortality rate causing some to wonder if it’s virulence has increased. The worrisome factor “is the reported mortality rate,” says McGill University. As of Jan. 13, there were twenty confirmed deaths in Canada attributed to H1N1. “There are more deaths than what we expect for the regular H1N1 influenza, The strain this year could be more virulent . 96% of this year’s lab -confirmed influenza is H1N1. The virus is unusual in that it appears to affect younger people more than other strains of seasonal influenza. People 20 to 65 are being hit harder than usual, comprising 52% of flu cases. However, if you look at Europe, it’s still H3N2. Its an example of how you never know what the flu is going to do.” Alberta confirmed a death on Jan. 8, due to the virus H5N1, an avian virus. The deceased woman had recently returned from China. The mortality rate is higher with H5N1 than H1N1, “but fortunately, it’s not an easy virus to transmit”. So far, it seems that there are no cases of H5N1 transmission from human-to-human. It seems like the cases of H5N1 are few and far between and related to contact with birds in China. Patrick Janukavicius, Montréal, Quebec. In the same period, at least 20 children have reportedly died of the same strain in USA.
update 12 Jan 2014 THE ANTIFLU VACCINE DECEPTION: this review by Doc Joe Mercola stresses the disease-mongering myths, futility and risks in real life of flu vaccination and antiflu drugs eg Tamiflu ; and the overwhelming importance of natural immune boosters like Vit D3 & C, zinc, selenium, herbs, and hygienic prevention.
1 Jan 2014 CURRENT INFLUENZA STATUS: The 22 December solstice is the sun at its southern nadir seen from planet Earth, the onset respectively of real winter in the Northern hemisphere, and real summer in South Africa. Last year the Gregorian New Year heralded a fierce flu season in the northern hemisphere, and as usual feathered- and jet-propelled air travel brought the corresponding surge at the bottom of Africa.
And ominously, the Plagues & Pandemics (Howard Phillips 2012) of temperate climates that did so much historically to mould global demography not least the past 360 years in South Africa ( –STDS- pox, bubonic, polio, cholera, influenza, and now tuberculosis, Mad Cow disease, and HIV-AIDS). and especially antibiotic-resistant germs – are all on the increase despite (or because of) the increasingly futile $trillion armamentarium of 20th century designer vaccines and other antimicrobials..
Pneumonia is a welcome friend of the old, often rapidly relieving prolonged degenerative incapacity; such ending mostly by virus respiratory infection the gateway for the final bacterial infection.
Unlike the selflimited coronavirus common cold, breath-and hand-borne type A influenza, although usually mild in the well, is the commonest trigger in the frail. Many of us in our (grand)parents’ time lost relatives in the 1918/1919 “Spanish” H1N1 flu pandemic. But that was a unique global catastrophe because it killed mostly armies of healthy men, and then young working adults, apparently from cytokine storm, with 30 % of the workforce out for up to3 weeks if not 20% mortality. This is harrowingly described in the recently published Letters ( to his Mother) of Dr Arthur Conan Doyle, who lost – apart from his first wife to TB- more young relatives to the flu than to warfare.
The recent spring months here – apart from seasonal allergies -have seen declining viral respiratory illness in Cape Town, with the upper respiratory accent often shifted down to more gastritis-enteritis .
But New Year 2014 UK and northern North America forecast and are having a wet if not white New Year. ‘Flu rates are reported already high and rising in USA and Canada– mostly influenza A H1N1(swine-avian flu-the main 1918/19 killer); including already 6 deaths in USA and 3 in Canada.
but not in Europe, where the influenza (A > B) prevalence is still low and slightly more H3N2 than H1N1; in UK there has rather been been increase in RSV respiratory syncytial virus bronchitis in infants. . .
In fact by 28 December the exploding H1N1 deathtoll had hit 13 in Texas alone; especially in youths; with increasing Tamiflu resistance reported eg in Missisippi.. On 24 Dec the USA CDC mailed an emergency Advisory Notice to Clinicians: Early Reports of pH1N1-Associated Illnesses for the 2013-14 Influenza Season: From November through December 2013, CDC has received a number of reports of severe respiratory illness among young and middle-aged adults, many of whom were infected with influenza A pH1N1 pdm09 virus. Multiple pH1N1-associated hospitalizations, including many requiring intensive care unit (ICU) admission, and some fatalities have been reported. While it is not possible to predict which influenza viruses will predominate during the entire 2013-14 influenza season, pH1N1 has been the predominant circulating virus so far. For the 2013-14 season, if pH1N1 virus continues to circulate widely, illness that disproportionately affects young and middle-aged adults may occur.
Our regional South African Communicable Diseases Institute says , “H1N1 was documented here from April to September. But of 2566 pts with severe respiratory illness for January to October 2013 enrolled and tested at the five sentinel sites, only 6% were positive for influenza – mostly virus -H1N1. A pneumonia case in Cape Town was found to be due to Leigionnaire’s.
Now from China 147 human cases of avian influenza H7N9 have been confirmed including 48 deaths. – especially from poultry contact. No vaccine is currently available for avian influenza (H7N9) virus.
SAPA–AFP, 10 December 2013: Resistant flu virus keeps contagiousness. A mutant form of the H7N9 flu virus that is resistant to frontline drugs is just as contagious as its non-resistant counterpart, according to a study, published inthe journal Nature Communications. The virus has claimed dozens of lives since its outbreak in February. H7N9 is believed to have spread to humans from poultry, where it circulates naturally. The World Health Organisation (WHO) said on its website that “so far”, no evidence has emerged of “sustained” transmission of H7N9 among people.
And H7N1 and H7N7 has broken out in ostriches in South Africa,
So never mind the common cold coronaviruses and many other prevalent infections, increased caution is due against all common diseases at this season- both the USA H1N1 swine flu circulating the past few years, and now the Chinese H7N9 flu. . And the MERS-Co Virus Middle-East SARS-type outbreak has not gone away… 9 new cases reported the past week or two from the KSA alone .–the-deadly-middle-east-coronavirus-outbreak/
A current NEJM has a new report of a trial of quadrivalent Vaccine for Prevention of Mild and Moderate-to-Severe Influenza in Children by vaccine manufacturers GSK. The vaccine reduced severity by perhaps 70%- but at a cost of 1.5% serious adverse events, 50% more than the control group (hepatitis A vaccine only). The question remains- why risk flu vaccine’s ~1.5% serious adverse events when a single high dose of vitamin D3 300 000iu even just annually, and regular vitamin C with a multivite including zinc and selenium (at trivial cost ) largely cover one against a multitude of infections including AIDS and TB, and all degenerative health problems?
Is it coincidence, or divine evolution, that we have had available at low cost for about 60 year (never mind zinc, selenium, iron, iodine, vitamins A and vitamin E) two safe natural major antimicrobials in vigorous safe dose – vitamins C and D3? Medico-Pharma Big Business and governments have been heavily discrediting and ruthlessly suppressing these for their own profiteering vested interest even as plagues of HIV, TB, influenza rage, and Big Business determinedly profits hugely from killer smoking and alcohol sales despite increasing marketing restriction? South Africa- a major producer of alcohol and tobacco-smoke, and fossil-fuel-burning power stations, factories and motorvehicles – continues to lead the world with the highest road and respiratory death rates despite zealous attempts to reduce their lethal use.
Apart from optimal hygiene including avoiding livestock and poultry contact, smoking, alcoholism and pollution including swimming and sick buildings- air-conditioning- what can we take to minimize avoidable influenza ie immune depletion risk? apart from enough sunshine, exercise, rest, sleep, walking barefoot, not carrying a cellphone, and good mixed fresh organic diet? The clinical benefit of influenza vaccines is anything but proven, and the adverse risks appreciable.
Big Business and thus governments and the media profit from illness, so they keep publishing articles promoting Big Business: new antibiotics, vaccines and other synthetic drugs that do not prevent or cure but if anything perpetuate chronic degenerative obesity-diabetes-vascular-respiratory,- digestive-arthritic-cancer diseases; – and GMO-genetically modified preserved food and bottled drinks stuffed with slow poisons like refined cornstarch – fructose; salt; sucrose and cereals, soya, Roundup, antibiotics, preservatives, estrogenics, aspartame, and especially boiled and baked omega6 and sugars; instead of marine omega3 and MCT- medium chain triglyceride virgin coconut oil, and unrefined cereals eg oats, wholewheat bread etc..
Big Business and it’s cash-cow Disease Industry decries the natural healthgiving lowsugar Asian/ Mediterranean diet-organically pastured and grown livestock meat and dairy products, lightly cooked if not raw (oily) fish, fruit and nuts, coloured veggies, and plenty of oils in their natural plant form. These were the norm till food processing became Big Business in our lifetime post WW2, and the developed world was bluffed by Organized Medicine, the Food Barons and Big Pharma with the masterly fiction of Ancel Keyes, into jettisoning the natural longevity “sea and farm” diet of the east eg Japan, and West eg Mediterranean (fresh produce & cholesterol-rich dairyproducts, meat and fish) for the Diet Deception (Gary Taubes, Tim Noakes) and Bad Pharma ( James le Fanu, Ben Goldacre) of Ancel Keyes‘ low-fat high-refined cereals, margarine; and the cholesterol -busting and psychotropes/ painkillers /antidementia/antivascular/ antidiabetic disease Designer Drugs-for-all myths.
It spends multimillions promoting alcohol, smoking and ever-newer designer prescription drugs and vaccine, and disinformation on old well-proven cheap drugs like reserpine, amilozide, metformin, natural physiological human hormone replacement, natural antioxidants and anti-inflammatories , and decrying ineffective but deliberately lowdose and isolated or imbalanced vitamins and minerals .
The ATBC vits A+E trial (isolated highdose vits A and E) was one such farce in very high risk smokers in an icy climate. . Others have been the recent Norwegian trial using only up to 1000iu vit D supplement a day,
*a commercial multisupplement in the TACT post-heart attack trial – but the composition of the multisupplement included only deficiency-disease prevention microdoses of micronutrients including 100iu vitamin D3/d and equally negligible vitamin K- not pharmacological doses of key vitamins eg vits B, C, D & K2 that are well proven to greatly reduce infections and chronic degenerative diseases ;
* the Physicians’ Health Study randomized elderly professional men to placebo or combinations of vitamin C (500 mg synthetic ascorbic acid), vitamin E (400 IU of synthetic alpha-tocopherol), beta-carotene (50 mg Lurotin), and a multivitamin (Centrum Silver – this included anti-deficiency disease low dose of all common vits and minerals BUT only 400iu Vit D3), .
* The third study- on lowdose (traditional anti-deficiency disease) Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer was simply a literature review of 26 best-quality published trials of microdoses – not pharmacological safe macrodoses.
ie these three trials published in this Annals Internal Medicine issue to please Big Pharma advertisors to discredit supplements shared the usual problem of now well-known futile lowdose supplement doses at least of vitamins D3 and K, if not also vitamin C in the multigram dose scientifically promoted by the Drs Stone- Klenner-Pauling followers.
Sir Jack Cecil Drummond (1891-1952) was one of the world’s pioneer 20th century biochemists and nutritionists in UK, from 1916- 1952 discovering or defining and promoting under his world-famous biochemist professors Rosenheim, Halliburton and Funk the role especially of vits A, B, C and E. Thanks to his and Churchill’s forceful vision and foresight, he oversaw food supply and diet and thus keeping Britons healthy through and after WW2. He was so successful in promoting healthy cheap and unpatentable micronutrients and natural fresh food (in the face of the mushrooming megaprofit processed food and designer drug industry) that it speculatively led to his and his family’s 1952 assassination by competing interests in France –The Vitamin Murders, Fergusson 2007. .
MURDER BY DENIALISM: It is incontrovertible common cause that irrational and often jealous medical denialism costs endless lives:
* Scurvy prevention: Dr James Lind (who did the first ever recorded clinical trial) showed by 1750 that sailors’ scurvy on long sea voyages was preventable; but despite his pioneer discovery, the British navy cost the lives of thousands more seamen from scurvy when the Admirals neglected for 50years until the Napoleonic Wars to supply the fresh produce- eg limes – that rapidly cured and prevented the lethal scourge.
This despite the fact that another UK navy surgeon Dr John Woodall had already over 130 years earlier- by 1617 – published in UK The Surgeon’s Mate stating We have in our owne country here many excellent remedies generally knowne,- Scurvy-grasse, Horse-Reddish roots, Nasturtia Aquatica, Wormwood, Sorrell, and many other good meanes… to the cure of those at home…and Sea-men returned from farre who by the only natural disposition of the fresh aire and amendment of diet, nature herselfe in effect doth the Cure (of scurvy- for which antiscorbutic citrus had been known since antiquity) without other helps. the Lemmons, Limes, Tamarinds, Oranges, and other choice of good helps in the Indies… do farre exceed any that can be carried tither from England.
* Childbed fever prevention: in 1865 Dr Ignaz Semmelweis (1818 -’65) an AustroHungarian Roman Catholic ob-gyne in Vienna, was locked up, and beaten to death within weeks, because he showed – to the outrage of his peers- that handwashing with chlorinated lime eradicated the epidmic puerperal fever (three times that in the midwives’ ward) in the doctors’ labour wards; 70years before Thir Reich terrorists took charge, his senior colleagues reacted violently to his progressive promotion of (what was already more advanced British and French) hygiene and science, and his urging them to wash their hands after examining corpses before examining women in labour.. . Tragically for Semmelweis and new mothers in the Hapsburg empire then, Pasteur (b 1822) and Lister (b 1827) ‘s germ antiseptic discoveries were already being implemented further west, but had not yet been publicized.
*metformin after centuries of use as an antidiabetic herb galega officinalis, and its extraction as an antidiabetic in 1922, came into increasing use globally from the 1950s as the best treatment for type 2 diabetes, but the USA- to protect their own new patent antidiabetic drugs – ruthlessly suppressed its use there (like that of the natural salt lithium for manic depression) for 40years till the mid-1990s.
*AIDS and ART denialism: until 5 years ago in South Africa the overwhelming-majority “people’s” government (with the country’s vast resources), and its successive “health” ministers, cost the lives of an estimated 300 000 AIDS victims through sufferers – indigent state dependents- being denied antiretroviral ART drugs, (never mind still till now denied quality education and civil security, and thus adequate basic nutrition, and meaningful housing, jobs and thus hope.) Genocidal AIDS denialism about which the still-ruling (since 1994) leadership cadre did nothing until under intense international pressure and repeated Constitutional Court orders, combined with political rival factioneering in the ruling party, they ousted the denialist president and his denialist Disease Minister in 2008.
DENIALISM TARGETS IN NUTRITION:
VIGOROUS VITAMIN C ASCORBIC ACID PHARMACOTHERAPY : Much effort and Big Pharma money has been spent to denigrate the irrefutable science-based work (between their advocacy years shown) of Drs Irvine Stone (1934-1984), Fred Klenner(1948-74) and Linus Pauling (1970-1991) of antibiotic dose >50 to 1000 mg/kg/d pure vitamin C (not the antiscurvy 10mg/d) – as a universally needed essential in primates. We primats, like guineapigs and a few birds and fish species, are among the few that do not make their own since we lost the needed gene and thus enzyme in our evolution..
It took about 150 years after Lind’s publication for the antiscorbutic factor to be named as vitamin C by Dr Jack Drummond, another 10 years for it to be assayed and its structure proven- but despite the pioneering clinical work of Dr Fred Klenner in the 1950s proving the lifesaving benefit of tens of grams a day intravenously, it took another 20 years before Dr Linus Pauling took up Dr Irvine Stone’s conviction and put highdose vitamin C on the world Nobel prize map; just on Pubmed, vitamin C has >51 000 citations since 1921, and intravenously in 763 entries since 1946, with Dr Fred Klenner reporting it intravenously asmajor antibiotic in the Southern Medical journal from 1948..
The 2009 book Injectable Vitamin C and the Treatment of Viral and Other Diseases collection of medical journal papers from the 1930s to 2006 details the exhaustive scientific evidence proving the uniform benefit of even 1gm a day vit C both as an antimicrobial antiinflammatory antioxidant and immunomodulator against major crippling / lethal diseases from polio to tuberculosis, pneumonia, hepatitis, rabies, encephalitis, neuritis, poisoning, cancer, and pancreatitis;
and the persistent resistance of the FDA and other multinational Regulators to recognize (so as to protect their domestic patent drug manufacturers- Big Pharma and their politician and civil service lobbyists )- such uniquely safe and effective natural drug therapy. The final chapters of that 2009 book pose the crucial questions of overwhelming vested interest by the organized medical – hospital –pharmaceutical mega-industry and governments in not eradicating preventable disease, the Big Pharma banning of natural effective remedies- The Origin of the 42-Year Stonewall of Vitamin C, and Medical Resistance to Innovation,
The University of Oregon, the Riordan-Gonzalez group and more recently Hemila and Chaker‘ and Ullah et al’ s 2012 reviews have published much validating what Drs Goodall, Lind, Drummond, Stone, Klenner, Pauling and Cameron started.VIGOROUS VITAMIN D3 CHOLECALCIFEROLPHARMACOTHERAPY costing wholesale ~ <US$0.5/month for ~200 000iu /month in South Africa) reduces serious infection by perhaps 90% ie 9fold: . eg 80iu/kg/d – 500iu/d (15000u/month) for an infant, 50 000iu/wk or 200 000iu/mo for an adult; who if obese, may need two to three times the average dose, to achieve the (?) optimal 25OH vit D level of around 70ng/ml for health, higher for any acute or chronic chronic illness.
The modern prophets of vitamin D3 have been the three pre-WW2 doyens :
Prof Chris E Nordin (MB ChB 1950) working in bone physiology for 60 years now; 84 papers on vitamin D on Pubmed
Prof Walter Stumpf (1927-2012; MD 1952) the recently deceased professor at North Carolina University, neuropsychiatrist and radiobiologist in his 60year medical career with over 500 publications (76 on Vit D on Pubmed) including early discovering that vitamin D targets all systems and diseases; professor-walter-e-stumpf-ahead-of-his-time/ and https://healthspanlife.wordpress.com/tag/stumpf-dr-walter/
paralled by Prof Robert Heaney (MD 1951) at Creighton University, osteoporosis and nutrition authority with 119 vitamin D papers on Pubmed since 1982, over 400 publications to date;
succeeded by Prof Mike Holick (PhD 1971, MD 1976) with 391 publications on vitamin D since 1970 on Pubmed, who has done more than most to show that the maximum daily body production of vitamin D3 with plenty of sunlight is enough to prevent rickets and reduce all disease, but nowhere near the pharmacologically therapeutic 80iu/kg/d needed to maintain a vigorous all-disease protective bloodlevel of 60-100ng/ml.
and Dr John Cannell (MD 1976, registered psychiatrist from 1993, nutritionalist), a legendary whistleblower . who successively campaigned against #cigarette smoking; and uncovered: # the cigarette-smoking (Black Lung) compensationitis fraud of miners’ pneumoconiosis; #the fictitious inflated “above national average” school results (Lake Woebegone) that all states were inventing and reporting (as is still happening – mass government deception- in South Africa) ; then the
# recovered memory therapy (RMT) scandal – a form of psychotherapy in which patients recovered memories of abuse that they had no previous memory of. Such therapy resulted in false memory syndrome (FMS) of events that never occurred as well as an epidemic of multiple personality disorder (MPD), a rare disorder historically conceived of as being a hysterical disorder. Unfortunately, many MPD patients believed the psychiatrist conducting the RMT and went home to falsely accuse their parents and others of horrendous acts that never occurred. Cannell teamed up with two Harvard professors to write a peer reviewed paper on RMT, debunking the witch-hunt; then since the 1990s researching and promoting # vitamin D deficiency as major cause of much psychopathology including autism, and vigorous vitamin D therapy to correct multiple diseases, through the Vitamin D Council. He has (co)authored some 13 papers, and published a book. .
Now a major longterm German Cancer Research screening program has just publishd the 2002-2013 ESTHER study (Perna ea) of 10 000 citizens followed with serial 25OH vit D levels; to assess the association of apparently unsupplemented vit D levels with fatal and nonfatal CVD in the same study population. Follow-up data, including survival status, up to over 9 years. Comparing subjects with 25(OH)D levels below 12ng/ml and above 20ng/ml resulted in the lower vitamin D level cohort showing a higher hazard ratio of 1.27 (95% confidence interval = 1.05-1.54) for total CVD and 1.62 (1.07-2.48) for fatal CVD in a model adjusted for important potential confounders. No significant association for nonfatal CVD was observed. In dose-response analysis, we observed an increased cardiovascular risk at 25(OH)D levels below 30ng/ml. Results for CHD and stroke were comparable to the results obtained for the composite outcome CVD. Our results support evidence that low 25(OH)D levels are associated with moderately increased risk of CVD, BUT the observed association is much stronger for fatal than for nonfatal events.
But the benefit of sunlight in healing tuberculosis has been used for well over a century; while the Google antibiotic benefit of calciferol on Pubmed goes back at least to 1950.
In a prospective 16 mo trial in press from Australia, vit D3 even just 60 000iu/month (ie 2000iu/day) halved antibiotic use in seniors. (Tran, Neale ea 2014) Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial.
Since the toxic dose of vitamin D long term reportedly may be as high as 600 000iu/day or a blood level well >150ng/l , imagine how much better the antimicrobial benefit of vitamin D3 at 80 to 100iu/kg/day or pro rata – even higher eg 10 000+iu/day for obese people who sequester more vit D in fat. .
Dr Robert F Cathcart wrote 30 to 20 years ago in Med Hypotheses. 1981 Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy The amount of oral ascorbic acid tolerated by a patient without producing diarrhea increase somewhat proportionately to the stress or toxicity of his disease. Bowel tolerance doses of ascorbic acid ameliorate the acute symptoms of many diseases. Lesser doses often have little effect on acute symptoms but assist the body in handling the stress of disease and may reduce the morbidity of the disease. However, if doses of ascorbate are not provided to satisfy this potential draw on the nutrient, first local tissues involved in the disease, then the blood, and then the body in general becomes deplete of ascorbate (Anascorbinemia and Acute Induced Scurvy). The patient is thereby put at risk for complications of metabolic processes known to be dependent upon ascorbate. 1984 Vitamin C in the treatment of acquired immune deficiency syndrome (AIDS). evidence is that massive doses of ascorbate (50-200 grams per 24 hours) suppress the symptoms of the disease and can markedly reduce secondary infections. In combination with usual treatments for the secondary infections, large doses of ascorbate will often produce a clinical remission which shows every evidence of being prolonged if treatment is continued. .. despite continuing laboratory evidence of helper T-cell suppression. There may be a complete or partial destruction of the helper T-cells during an initial infection that does not necessitate a continuing toxicity from some source to maintain a permanent or prolonged helper T-cell suppression. However, it is possible ascorbate may prevent that destruction if used adequately during that prodrome period. Emphasis is put on the recognition and treatment of the frequent intestinal parasites. Food and chemical sensitivities occur frequently in the AID syndrome and may aggravate symptoms considered to be part of the AID syndrome. A topical C-paste has been found very effective in the treatment of herpes simplex and, to a lesser extent, in the treatment of some Kaposi’s lesions. Increasingly, clinical research on other methods of treating AIDS is being “contaminated” by patients taking ascorbate. 1991 A unique function for Vitamin C is as reducing substance, electron donor. When vitamin C donates its two high-energy electrons to scavenge free radicals, much of the resulting dehydroascorbate is re-reduced to vitamin C and therefore used repeatedly. Conventional wisdom is correct in that only small amounts of vitamin C are necessary for this function because of its repeated use. The point missed is that the limiting part in nonenzymatic free radical scavenging is the rate at which extra high-energy electrons are provided through NADH to re-reduce the vitamin C and other free radical scavengers. When ill, free radicals are formed at a rate faster than the high-energy electrons are made available. Doses of vitamin C as large as 1-10 g per 24 h do only limited good. However, when ascorbate is used in massive amounts, such as 30-200+ g per 24 h, these amounts directly provide the electrons necessary to quench the free radicals of almost any inflammation, and reduces NAD(P)H and therefore provide the high-energy electrons necessary to reduce the molecular oxygen used in the respiratory burst of phagocytes. In these functions, the ascorbate part is mostly wasted but the necessary high-energy electrons are provided in large amounts.
A recent review from Atlanta Kearns ea found 30 papers which aggregate to show that annual vitamin D3 dose (not D2) of optimally 300 000 to 500 000iu (wholesale cost ~R5 in South Africa) for deficient adults is best for avoiding poor patient compliance with minimal risk and major benefit.
THE INFERIORITY OF VITAMIN D2 SUPPLEMENT: It should be noted that the long-used Lennon’s Strong Calciferol datasheet (1974 updated 2004) does not indicate that this 50 000iu tablet labelled ‘calciferol’ is in fact vitamin D2 (ergocalciferol), not the fourfold more potent cholecalciferol D3 formed by sunlight in the skin. This is disclosed only on the Lennons website.. and in the South African Medicines Formulary. So ‘Strong Calciferol’ in South Africa (actually the D2 not D3 form of calciferol) is convenient but seriously deceptive mislabeling- much weaker than the ideal vitamin D3, and therefore its effect unpredictable compared to D3- in fact Dierkes ea Norway show that giving D2 may actually lower 25OH vit D level in the blood.. Sadly, despite this being reported to the local manufacturers and authorities, no correction of the clinically serious misperception created by the Strong Calciferol label and insert has been issued to health practitioners by the Medicines Control Council and the manufacturer Aspen-Lennons.
A recent 8yr study in Cape Town blacks Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in South Africa Martineau, Nhamoyebonde ,Wilkinson ea confirmed that vitamin D deficiency (serum 25(OH)D <20 mg/L) is associated with susceptibility to tuberculosis (TB) in HIV-uninfected people in Cape Town as it is Europe. Vitamin D deficiency was present in 62.7% of 370 participants and was associated (OR ~5.4) with active TB in both HIV-uninfected and HIV-infected -(P < 0.001) people. Vitamin D status varied according to season: 25(OH)D concentration was double in summer-January- March compared to winter (23 vs 12ng/l; P < 0.001). Reciprocal seasonal variation in TB notifications was observed:lowest in autumn and highest in spring October through December (4,2 vs. 5; P < 0.001). Vitamin D deficiency is highly prevalent among black Africans in Cape Town and is associated with susceptibility to active TB both in the presence and absence of HIV infection.
Antimicrobial implications of vitamin D is detailed by Youssef, Peiris ea (USA Dermato-Endocrinol 2011) against all microorganisms – viruses, fungi, bacteria, protozoa (except perhaps leishmaniasis) as both profound prevention and therapy; in many cases without commercially invented marketed antimicrobials to which there is growing and deadly microbial resistance, let alone toxicity.. There is evidence that seasonal vitamin D deficiency status contributed greatly to the 1918/19 flu-pneumonia pandemic (Grant & Giovannucci 2009).
and finally, a month ago JAMA published from Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic Antiretroviral-Naive HIV-Infected Adults in Botswana A Randomized Clinical Trial, that Micronutrient deficiencies occur early in human immunodeficiency virus (HIV) infection, and supplementation with micronutrients may be beneficial; however, its effectiveness has not been investigated early in HIV disease among adults who are antiretroviral therapy (ART) naive. 2 year supplementation with either daily vitamins BCo, C and E, selenium alone, or B,C,E with selenium vs placebo: study conducted in 878 patients infected with HIV subtype C with a CD4 cell count greater than 350/μL who were not receiving ART between 2005 and July 2009. Results participants receiving the combined supplement of vitamins plus selenium vs placebo had half the risk of reaching CD4 cell count 250/μL or less (adjusted hazard ratio [HR], 0.46); and secondary events of combined outcomes for disease progression or AIDS-related death, whichever occurred earlier [adjusted HR, 0.56); . There was no effect of supplementation on HIV viral load. Multivitamins alone and selenium supplementation alone were not statistically different from placebo for any end point. Reported adverse events were adjudicated unlikely related to the intervention, and there were no notable differences in incidence of HIV-related and health-related events among study groups.Conclusions and Relevance In ART-naive HIV-infected adults, 24-month supplementation with a single supplement containing vitamins BCo,C,E and selenium was safe and significantly reduced the risk of immune decline and morbidity. Micronutrient supplementation may be effective when started in the early stages of HIV disease.the universities of Miami, Harvard and Florida
THE PARADOX OF THE GLUCOSE- ASCORBIC ACID- CHOLESTEROL- STEROID CASCADE: Is it coincidence, or evolution, that the basic animal fast-energy circulating anabolic substrates are glucose, fatty acids and aminoacids? from which basic glucose C6H12O6 ( from ingested fructose C6H12O6 and sucrose C12H22O11, or fats or protein) the liver manufactures the basic cardinal steroid cholesterol C27H46O. Then from cholesterol we metabolize by adding or splitting off carbon molecules the crucial anabolic and regulating human hormones- 1. ouabain C29H44O12 the adrenal hormone made also in the hypothalamus and heart ; adrenal), 2. active calciferol C27H44O the strengthening and reproductive secosteroid; 3 the prime sex/ reproductive steroids pregnenolone C21H32o2, and thence progesterone C21H30O2, testosterone C19H28O2, DHEA C19H24O2. and thence estradiol C18H24O2. and 4 the prime adrenal mineralo/glucocorticoid steroids cortisol C21H30O5, aldosterone C21H28O5.
But we primates and a few other species lost the ability to synthetise on demand in quantities of grams a day the crucial vitamin C ascorbic acid C6H8O6 that is key to all the above. And vested interests in the Disease Industry want us to believe the biological nonsense heresy that we must ingest minimal unprocessed foods- cholesterol, fats (especially dairy, marine oil Omega3 and medium-chain triglyceride- coconut oil) and abundant vitamins C and D3, but eat abundant processed foods- refined plant Omega6, refined carbs- fructose, sucrose, fruit juice, cooldrinks, cereals, confections- which overload causes insulin resistance and thus lipidemia, obesity- metabolic syndrome -diabetes, cancer and cardiovascular disease.
The Semmelweis reflex: A current Wiki essay sums up the current genocidal problems of deliberate deceptions/denialism in Diet, Vitamins and causality – for ruthless profit and possibly cynical eugenics: “The Semmelweis effect is a metaphor for the reflex-like tendency to reject new evidence or new knowledge because it contradicts established norms, beliefs or paradigms.The term originated from the saga of Dr Ignaz Semmelweis, who discovered that childbed fever mortality rates reduced ten-fold when doctors washed their hands with a chlorine solution before examining patients. His hand-washing suggestions were rejected by his contemporaries, often for non-medical reasons. For instance, some doctors refused to believe that a gentleman’s hands could transmit disease (see Contemporary reaction to Ignaz Semmelweis). In his book The Game of Life, Timothy Leary provided the following polemical definition of the Semmelweis reflex: “Mob behavior found among primates and larval hominids on undeveloped planets, in which a discovery of important scientific fact is punished”. The expression has found way into philosophy and religious studies as “unmitigated Humean skepticism concerning causality“.”
Idealism, ethics may evolve; but the problem of human bigotry, self-interest and subjective ie personal bias do not diminish, they spread. It is classic that Semmelweis (1818-1865) the observant innovative Catholic medical scientist of his time (before microbes and antiseptics were known) was fatuously condemned not just by his jealous competing Vienna colleagues, but even by his progressive and reformist Copenhagen contemporary obgyn Prof Carl Levy (1808-1865)- who outlived him by only 4 months;
ironically at the same time that their Copenhagen contemporary Dr Soren Kierkegaard (1813-1855) was increasingly isolating himself on the lonely ethical journey against the convenience lazzez- faire tide, writing for ethical life and religion against the hypocrisy of the Church and becoming the father of both reformist theology and psychology. But unlike Semmelweis who was way ahead of the bioscience and humanity of his time, Kierkegaard stuck to and isolated himself in promoting the incompatible ie blind-faith-based religion – the dilemma of Abraham’s conviction (or delusion) to sacrifice his son- and ethical morality;
and closely followed by Rudolph Steiner (1861-1925) another more profound European thinker who bridged science, spirituality, progressive education, architecture, agriculture, natural medicine, nutrition, and social reform;
contrary to the rationalists of the 19th Century “Age of Enlightenment” and since, like British historian-philosopher -ethicist Winwood Reade (1838 – 1875) who published the enduring secularist’s bible The Martyrdom of Man (1872), of which Churchill wrote 25 years later “he was right but wrong to say it” on the book’s critique of the wrongs of war and religion, of mankind’s selfishness, corruption and destructiveness (by the greedy aggressive acquisitive minority) against the weak masses and the environment) that carries on worse in the 21st century than even the 20th century; and 150 years later bioscientist and philosopher Stephen Jay Gould (1941-2002) rationalized sadly the non-overlapping Magisteria of Science and Faith, objective “provable” science – which in fact is seldom immutably constant as is mathematics- and purely faith-based “unprovable” religious belief.
It was only a year ago that Richard Conniff published his column on Strange Behaviours, The Medical Martyrs. And the medical hero martyrs in this review- Semmelweis, Margaret Sanger, Drummond and Pauling – never made it onto his list.
But then nor did the modern medical freedom fighters Steve Biko, Agostinho Neto, Che Guevera. Jonas Savimbi, Neil Aggett, and the living spouse of Steve Biko, Dr Mamphele Ramphele….
Women of the Century apart (like Margaret Sanger, Marie Curie, Eleanor Roosevelt, Golda Meir, Indira Gandhi, Helen Keller, Benazir Bhutto, Mother Theresa, Aung San Suu Kyi -many of whom have been martyred), it is a philosophical debate whether among the men the medical martyr Semmelweis (1818-1865) ranks with his 19thC contemporaries- Lincoln (1809-1865), Kierkegaard(1813-1855), Pasteur (1822-95), Lister (1827-1912) ; and his successors (and 20th C leading achievers): Koch(1843-1910), Edison(1847-1931), Steiner (1861-1925), Gandhi(1869-1948), Weizmann(1874-1952), Churchill (1874-1965), Einstein (1875-1955), Jung (1875-1961), FD Roosevelt(1882-1945), JK Galbraith(1908-2006), Martin Luther King (1929-68), Pauling and Mandela as arguably giant enduring male leaders -innovators- teachers and achievers of the past two centuries.
Unlike eg Socrates, Hippocrates and Jesus of Nazareth, one of the five greatest polymath medical and ethical sages of all time Rabbi Dr Moses Maimonides (RamBam) avoided martyrdom by burying himself in practicing selfless medical service for sultan and peasants alike, and jurisprudence for his GreekoRoman based Islamic-Sephardic times and philosophy, like his guru predecessor Avicenna and his contemporary savant Averroes. .
CONCLUSION: Today it can be argued that the denial of effective phamacotherapeutic doses of especially vitamins C and D3, let alone supportive doses of balancing vits (A, B1,3,5,6,9 & 12, E and K2); the often-crucially deficient minerals (eg magnesium, sulphur, phosphate, iodine, zinc and selenium), and biologicals like human transdermal balanced HRT, coenzyme Q10, alphalipoic acid, milk thistle, cinnamon, fish oil, chondroglucosamine, DMSO, coconut oil, is a repetition of denialism of the germ theory, and of optimal physiological human micronutrition as well as macronutrition. .
– especially when patients are poor and thus malnourished, and plagued by diarrhoea and stress, TB, lipidemic vascular disease and cancer; and when antiretroviral ART- although life-saving- is even more diabetogenic and neurotoxic than untreated AIDs.
Even transdermal administration is better than nothing, perhaps better (for the frail and noncompliant eg oldies) than oral or injection eg of vitamins D3 & C and progesterone , metformin, (in addition to the usual magnesium chloride, vits A, BCo & E) may be beneficial whether by patch or cream for both healing, infection, calming, heart, circulation, infection, arthritis, osteoporosis, and neuritis, applied under coconut oil, codliver oil and DMSO as further analgesic, anti-inflammatory, memory and absorption enhancers.
REFERENCES: New reviews bear out the major benefits of micronutrient supplements selenium, zinc, silver, vits A, B, C, D, E; and DMSO, sutherlandia and aloe against HIV-AIDs. and co-infection;
Effect of micronutrient supplementation on disease progression in asymptomatic, antiretroviral-naive, HIV-infected adults in Botswana: a randomized clinical trial.Baum MK, Marlink R ea .JAMA. 2013 Nov 27;310(20):2154-63. .
In vitro effects of Sutherlandia frutescens water extracts on cell numbers, morphology, cell cycle progression and cell death in a tumorigenic and a non-tumorigenic epithelial breast cell line.Stander A, Joubert AM. ea, J Ethnopharmacol. 2009 Jul 6;124(1):45-60
below are some of the most recent 94 studies of vitamin D and human infectionin published just in 2013:
New insights on the role of vitamin D in the progression of renal damage: Kidney Blood Press Res. 2013;37:667-78. . Lucisano S, Santoro D.ea Many studies indicate relationship between hypovitaminosis D and survival, vascular calcification, bone mineral metabolism, immune, cardiovascular and endocrine. Vitamin D analogs reduces proteinuria, in particular through suppression of the renin-angiotensin-aldosterone system (RAAS) and exerts anti-inflammatory and immunomodulatory effects. In particular vitamin D deficiency contribute to an inappropriately activated RAAS, as a mechanism for progression of chronic kidney disease (CKD) and/or cardiovascular disease. Human and experimental models of CKD showed that vitamin D may interact with B and T lymphocytes and influence the phenotype and function of the antigen presenting cells and dendritic cells, promoting properties that favor the induction of tolerogenic T regulators rather than T effectory. Interstitial fibrosis may be prevented through vitamin D supplementation. .
Should vitamin D supplementation be a regular part of asthma care? Gordon BR.Otolaryngol Clin North Am. 2014 Feb;47:97-108. .Vitamin D (vitD3) deficiency occurs frequently and has profound effects on health, especially asthma.
Vitamin D in asthma and future perspectives.Huang H, Zarogoulidis K. ea Drug Des Devel Ther. 2013 Sep 23;7:1003-13.
vitamin D deficiency associated with development of Acinetobacter baumannii infections in critically ill patients?; Türkoğlu M, Aygencel G et al.; Journal of Critical Care 28 (5), 735-40 (Oct 2013)
Association between vitamin D and hepatitis C virus infection: a meta-analysis. Villar LM, Romero-Gomez M. ea World J Gastroenterol. 2013 Sep 21;19(35):5917-24.
Association between prehospital vitamin D status and hospital-acquired bloodstream infections. Quraishi SA, Christopher KB. Ea, Am J Clin Nutr. 2013 Oct;98(4):952-9.
Human parvovirus B19 associated dilated cardiomyopathy. Jain P, Jain A, Khan DN, Kumar M. BMJ Case Rep. 2013 Aug 5;2013.
The role of vitamin D supplementation in the risk of developing pneumonia: three independent case-control studies. Remmelts HH, van de Garde EM ea .Thorax. 2013 Nov;68(11):990-6.
Correlation between serum vitamin D level and severity of community acquired pneumonia in young children Ren J, Sun B, Miao P, Feng X. Zhongguo Dang Dai Er Ke Za Zhi. 2013 Jul;15(7):519-21. Chinese. http://www.ncbi.nlm.nih.gov/pubmed/23866270
Role of vitamins D, E and C in immunity and inflammation. Shaik-Dasthagirisaheb YB, Pandolfi F. J ea Biol Regul [Correlation between serum vitamin D level and severity of community acquired pneumonia in young children].Homeost Agents. 2013 Apr-Jun;27(2):291-5.
Pre-hospital vitamin D concentration, mortality, and bloodstream infection in a hospitalized patient population.Lange N, Christopher KB ea. Am J Med. 2013 Jul;126(7):640.e19-27.
Vitamin D deficiency in HIV infection: an underestimated and undertreated epidemic. Pinzone MR, Nunnari G. eA Eur Rev Med Pharmacol Sci. 2013 May;17(9):1218-32.
Vitamin D deficiency and sudden unexpected death in infancy and childhood: a cohort study.Cohen MC, Offiah A, Sprigg A, Al-Adnani M. Pediatr Dev Pathol. 2013 Jul-Aug;16(4):292-300.
Serum 25-hydroxyvitamin D3 and the risk of pneumonia in an ageing general population.Aregbesola A, Tuomainen TP. ea J Epidemiol Community Health. 2013 ;67:533-6.
Treatment of pulmonary tuberculosis.Nunn A, Phillips PP, Abubakar I.Curr Opin Pulm Med. 2013 ;19(3):273-9.
Role of vitamin D in children with respiratory tract infection.Esposito S, Baggi E, Bianchini S, Marchisio P, Principi N. Int J Immunopathol Pharmacol. 2013 J26(1):1-13.
Tuberculosis incidence correlates with sunshine: an ecological 28-year time series study.Koh GC, Dedicoat M. PLoS One. 2013;8:e57752.
Improving outcomes in patients with psoriasis.Tidman MJ. Practitioner. 2013 ;257:27-30, 3.
vitamin C refs & infection:
Authors’ perspective: What is the optimum intake of vitamin C in humans? Frei B, Birlouez-Aragon I, Lykkesfeldt J. Crit Rev Food Sci Nutr. 2012;52(9):815-29.
Micronutrients at the interface between inflammation and infection—ascorbic acid and calciferol. Parts 1 & 2: .Ströhle A, Wolters M, Hahn A. Inflamm Allergy Drug Targets. 2011 ;10:54-74- FULL TEXT IS ON LINE. .
Vitamin C for preventing and treating tetanus Cochrane Database Syst Rev. 2008 Apr 16;(2):