THE FDA GLITAZONE- ACTOS, AVANDIA- DISASTER CONTINUES.

neil.burman@gmail.com   

         The subservience of governments- led by Big Pharma’s protector  the FDA- to profit rather than patient interest is well shown in the ongoing protection of the glitazone antidiabetic drugs and their manufacturers GSK and Eli Lilly 

How much more clearly does the chairman of the  recent FDA Joint Committee have to state it, that these drugs have no distinctive role and should be banned, or reserved for last ditch trial of therapy under special regulator approval? 

It is revealing, as Dr Rosen says, that the USA Govt FDA (to this day in August)  still refuses to put patient benefit as the top priority- ie submissions for new drugs, and ongoing licencing of drugs, must depend primarily on  both evidence of need ie proven benefit of the new drugs at least equal to that of older or natural remedies, and more obviously on  low risk- ie low cost:benefit ratio compaed to proven drugs

How many of the FDA review committees who voted to retain Avandia  -other than Prof Capuzzi – had vested interests in the manufacturer (GSK)?

Where is the evidence to support anything but metformin titrated to tolerance,  and other natural insulin sensitizers which reverse weight gain, fractures, cancer and cardio/vascular diseases ( eg alphalipoic acid, carnitine, vitamins A to K,  lecithin, coQ10, ribose, fish oil, stevia, cinnamon, garlic, gymnema, coleus, fenugreek, curcumin, ginseng, melatonin, inositol, aloe, sutherlandia, cayenne,  acetylcysteine, and approriate chromium, magnesium, HRT etc),  as the only allowed and mandatory baseline drug therapy for type 2 diabetes? until this proves inadequate?

Never mind  glitazones  increasing the risk of dying from heart disease, at least 13 reports on Pubmed have appeared since 2005 on the link between rozglitazone and vision loss – more than doubling the risk of macular oedema. .

 With so many antidiabetic multiprotective natural remedies to choose from and simply combine against the now  chief self-inflicted degenerative killer , it is criminal to allow doctors to prescribe and pharmacists to dispense snakeoils like glitazones except as desperate last ditch.

Since these drugs’ manufacturers- GSK and Eli Lilly -are based respectively in UK and USA and are major money-spinners for those governemnts, naturally those governments will delay canning  these drugs for as long as possible. Its like banning smoking, or jailing and withdrawing drivers’/ gun  licences from those who drink and drive- permanently  

Who cares how many patients suffer and die when the ruthless manufacturers provide  handsome taxes, jobs, ‘research’ and advertising  money and lobbying fees?

At least in South Africa, the human rights Constitution and the Consumer Protection Act compel regulators and healthcare providers to ensure that such unnecessary and risky drugs are not routinely prescribed.  Yet a glance at Google shows that the South African media -who will do anything to avoid upsetting advertisors-  till today remain silent on the glitazone issue.

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