Monthly Archives: June 2010

BIG PHARMA-US GOVT CONSPIRACY FRAUD: THE NEVER-ENDING STORY OF DESIGNER SNAKEOILS- VIOXXES, FOSAMAXES, PSYCHOTROPES…

neil.burman@gmail.com  20100630

Pharma Fraud: the saga continues:

So Merck is also paying out $4,5billion to settle Vioxx damage cases…

  and now    Fri, Jun 25 2010  Jury orders Merck pay $8 million Fosamax damages 

 But as this column has described for almost 3 years  now, over 3000 cases of bisphosphonate osteonecrosis had already been  reported worldwide by 2006; the first case having been reported in about 1996.    

    And  leading university clinician Professor Dr  Scott Reuben gets a slap on the wrist 6 month jail sentence and > $300 000 fine for consistently faking drug  results ( Vioxx, Bextra, Effexor and even Lyrica ) for Merck and Pfizer- to bolster their multibillions sales. How much has he been paid / guaranteed to retire luxuriously remains untold.  

 So Meck now leads Pfizer ($3.4billion admitted  so far) in fines and damages penaties-  but both Pfizer    and Merck  still face untold billions in fines and damages in current ongoing litigation against them.  And worse to come- Merck and Bayer face massive damages claims over their contraceptives . This apart from the bakers’ dozen of shady practices listed against Bayer, of unquantified costs.    

  I recently saw my first associated case, a postmenopausal woman who had to have all her teeth removed and implants done after they came loose after a  few years on a bisphosphonate for osteoporosis prevention.  But perhaps my mother-in-law’s spontaneous cornflake collapse  of her lower femur in 1998 was my first case, someone had put her at about 70years  on bisphosphonate a few years before. She has never walked since, despite repeatedly failed  knee replacement. .

  There never has been the slightest  proven clinical justification for taking Vioxxes- Celebrex- Voltarens for pain, or bisphosphonates for osteoporosis/osteopenia, since there are safe  long-proven more effective natural painkillers, and safe supplements which restore normal bone without any risks, and (unlike bisphosphonates) with multisystem benefits that reduce all major common  degenerative diseases by 1/3 to 1/2 .   These modern synthetic designer drugs like bisphosphonates,   nonsteroidal anti-inflammatory “painkillers” ,  statins- cholesterolbusters, hypoglycemic drugs which actually promote obesity, neuro-drugs like  Neurontin, Lyrica, and Prozacs – Effexors, were and are  invented  to deceive patients into taking  lucrative $billion-dollar a year patent prescriptions  for widespread “prevention” and treatment, instead of the original natural supplements like eg herbs, biologicals, vitamins,and minerals which give relief and address the real causes with minimal risks and at low cost.        

 This  catastrophic fraud of Big Pharma- fostered by governments (for massive tax profits, job creation and ‘kickback’- God forbid that they are called bribes ) is  now exceeded in size only by the biggest Big Pharma scam ever,   last year’s  false swine flu pandemic scam  set up between the US government and Big Pharma, with multibillion dollar profits from unproven-value  mass testing,  vaccination and Tamiflu of unknown future disaster potential like thalidomide and stilbestrol proved to be.    (which in turn is exceeded perhaps by the biggest scam ever of modern times- the 2nd Iraqi war of GW Bush-Dick Cheney- Donald Rumsfeld- Halliburtons   that has now run most of this decade, the $Trillion War of Jo Stiglitz which will cost future generations of American and UK taxpayers infinitely more than that in compensation for injuries and deaths and debt; when there never were grounds – other than limitless oil to be pillaged- to invade Iraq any more than any of another dozen repressive dictatorship, when the obvious target against  Al Quaeda was always Afghanistan-Pakistan. )  

And the USA Govt and WHO (and hence most countries’ sheep -like regulators) actually changed the definition of a pandemic last year to perpetrate the trill$megabillion  swine flu  scam, and forswore proper randomized controlled clinical double-blind trials  to justify the vaccines and Tamiflu; and conveniently declared masses of old vaccine stores that were legally past their expiry date as recertified for use; and actually indemnified the vaccine manufacturers they chose against any future liability for failure of or complications from the vaccines.  

 Thus  the current USA government -with the backing of coerced allied governments  – invented the so far unproven if not risky swine flu vaccines, then handed the  recipes over to chosen manufacturers for free to produce and make $billions each within a year- with no liability –  at the incalculable expense of present and future taxpayers already reeling under the onslaught of USA-provoked overseas wars and  gigantic banking and oil cartel scams carefully orchestrated  by  deliberately failed  government   “regulation” which have caused the worst western global financial depression and environmental pollution  ever. .  

But these Big Pharma mafia  companies are bigger than the economies of many countries – apparently up to >8% of American gross domestic product- so they are protected by governments as too big to  jail or  close for fraud!   They couldnt care less about a few billion dollar fines  and damages for which they budgeted under cost of business- eg Bayer  last year paid $68billion for Wyeth the HRT  (Premarin- Provera) giant in North America…  

 As this column has previously reported,  the late greatest economist of modern times Ken Galbraith  would have said that  Big Pharma truly  rerpresents   the bared  backside  of western capitalist social democracy Naomi Klein’s  disaster capitalism (led by the modern pioneers of Human Rights for their own citizens if not their vassal dominions  – UK, Europe and USA)   – –  at its foulest .

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STATINS UNRAVEL: IN REAL LIFE CAUSE 50% MORE SERIOUS DISEASE THAN THEY RELIEVE:

14 June 2010: neil.burman@gmail.com:

 The statin scam unravels:

In Effects of statins in men and women in England and Wales,  and Individualising the risks of statins in men and women in England and Wales Profs  Julia Hippisley-Cox and Carol Coupland from Nottingham University UK report  a landmark  population based cohort study :      In 368 general practices some 10% of the 2million adults aged 30 years upwards were new users of statins.

 In real life patients, (not in highly selected subjects for double blind  RCT randomized controlled trials), the study  shows the comparative numbers for benefits and risks of statins:  compared to patients on no statins,  statins were associated with (per 10 000 subjects treated with statins) :

 *not significantly associated with Parkinson’s disease, rheumatoid arthritis, venous thromboembolism, dementia, osteoporotic fracture, melanoma or cancer of stomach, colon , lung , breast, kidney,or prostate.

*decreased risks of cardiovascular disease CVD:  271 cases prevented in women, 301 in men; and oesophageal cancer ;

*increased risks of moderate or serious: liver dysfunction 74 cases in women, 71 in men , acute renal failure 23cases in women, 29 in men, moderate or serious myopathy 39 cases in women, 110 in men; and cataract. 307 cases in women, 191 in men.

 thus they estimate that in total, in both sexes, CVD may be prevented in 286 but serious other disease caused in 50% more ie 422 cases.

But the study glaringly ignores, overlooks that statin use is not associated with two of the commonest risk factors for preventible major degenerative diseases of aging: no  reduction in increasing overweight- obesity, or diabetes .

Numerous analyses show that statins have justification  solely in patients with vascular disease, in whom they reduce all-cause mortality by some 16% and coronary heart mortality by up to 40% – but no reduction in non-vascular mortality. eg Wilt ea 2004 .

But in those without vascular disease and risk factors (smoking, obesity), vascular disease causes fewer than half of premature deaths; so statin use in such “primary prevention” population understandably has no significant benefit on reducing premature vascular mortality. Statins never significantly reduce non-vascular mortality – in fact Hippisley-Cox and Coupland show that non-vascular morbidity in creases by 50% more than the reduction in CVD.                                  So while there is  overall slight  reduction in all-cause  mortality,  there is highly significant increase in overall morbidity.

 So contrary to the UK professors  Wald and Law and the Statin industry who want statins to be available like aspirin over-the-counter, this major Nottingham University UK study contradicts  use of statins except with  severe resistant lipidemia- as occurs rarely due to genetic disease  in perhaps 1 in 70 South African Afrikaners.

Before focussing on mild to moderate hypercholesterolemia and prescribing statins – which in turn further reduce the vital antioxidant insulin sensitizer co-Q10 never mind essential cholesterol substrate  and thus precipitate all sorts of problems not least fatigue, myopathy and myolysis , doctors and society need to  address boldly the major risk factors, correction of which may reduce all-cause premature mortality by:

exercise – at least moderate and regular – by at least 25% ;

stopping smoking and alcoholism – each by perhaps half;

fish oil supplement perhaps 2gm omega3 a day – by almost half;

appropriate sex hormone replacement in deficient men and women by at least 1/3.

vigorous vitamins C,  D,  magnesium (with  broad other micronutrient  supplements) for widespread low intake- by perhaps 25 to 50% each;

avoiding obesity and diabetes including by using metformin to tolerance – by perhaps half.

Smoking, alcoholism and lack of exercise are cases  in point: they are  acquired addictions; so instead of being palliated with damaging statins, patients with vascular disease or major risk factors should  be compelled to undergo group therapy until exercising adequately and cured of  smoking, alcoholism  and the consequent weight gain and multisystem diseases  from bad food and bad  lifestyle choices.

PRETEEN PERIODS, L0WER FERTILITY, MORE OBESITY & CANCER:

neil.burman@gmail.com 13 June 2010

HORMONES SUPPRESSING THE PLAGUE OF HUMANS INFESTING PLANET EARTH?

Friday’s BBC newsbite  is about preteen UK girls’ high meat intake  association with earlier periods and breasts as well as obesity, and thus more infertility- polycystic ovary syndrome PCOS- and breast cancer .  

Is the link directly the increased protein intake? or increased cooked fat intake?  or increasing carbohydrate load due eg to cornstarch stuffing of the food chain? or increasing stress? or the environmental feminization of nature by ubiquitous estrogenic pollution?  

 Or is it due to  anabolic steroids used  used to increase profits, promote fast  livestock growth? Use of the  latter has been banned in Europe for over a decade, but is believed to be still prevalent in Europe in at least 10% of meat production due to difficulty in detection.     

  The FACS paper  on South Africa  anabolic steroid use in meat  dated  2009 – with the   only reference paper from USA  2000 – says “Public concern over the safety of South African meat and meat products which might contain hormones has increased, particularly since the use of hormones in meat production is not permitted in Europe (EU). The fact is, for decades in South Africa, almost all abattoir meat has been produced with the aid of hormones, and it is known to be a completely safe practice.”  

How can FACS – claiming to represent “ the South African National Consumer Union , the Association of Dietetics , the Directorate of Food Control of the Department of Health and professional representatives of other consumer-friendly organisations” support anabolic steroid use in the meat industry as ‘a completely safe practice’?

 A new paper from Europe  confirms the increasing problem of illegal anabolic ‘Hormonal growth promoting agents in food producing animals’  in the meat industry there. 

 The doyen of falling    fertility Professor Nils Skakkebaeck (in print on Pubmed since 1968) last reviewed environmental including hormone  meat contamination  in 2007,  and endocrine disruptors in general  last month,  after Deborah Cadbury’s exhaustive seminal 1997  review of his and others’ infertility work in The Feminization of Nature.  

 Our own andrologist Prof MS Bornman of Pretoria  has done extensive work on infertility and testicular cancer  in northern South Africa, the latest on association with industrial estrogen pollution in game –  eland-  there. 

 The Cancer Prevention Coalition  has recently filed a petition with the USA FDA that  ‘A Ban on Hormonal Meat is Three Decades Overdue’.

 It is just 25 years since Margaret Attwood’s chilling prophetic novel The Handmaiden’s Tale on male infertility in America.     And 15 years since the EU banned growth hormones in the meat industry. The saga is related in detail in Beef Hormone Controversy. which highlights yet again the power of (EU) voters’ voices to force government to act on the public’s  concerns;  whereas 25 years later Canadian and USA Industry still sway their governments to ignore concerns and evidence.

So is the livestock industry in South Africa, Australia, UK -EU  and North America- indeed everywhere-  still feeding us and especially our youth anabolic steroids in meat?   Human greed  knows  no limits.

It is in  the lifespan of some still alive  (from before my father’s birth in 1896) that  the use of commercialized  sex  hormones moved from  rejuvenation  and sexuality to in the past 50 years human birth control,  sex change,  bodybuilding , competitive gamesmanship, and speeding up meat  production. 

 Their increasing use is undoubtedly  contributing to the  feminization of nature, cancer burden,   and extinction of many species.  But perhaps their widespread use in the food chain  will peacefully reduce what some consider a plague, dangerous surfeit  of humans on Earth, if not just softening, more dimorphism- feminization – of male aggression and rapacity. An ironic twist to the age-old practice of male castration.

ABANDONED DOCTRINE OF TRUTH IN MEDICINE: POSTMENOPAUSAL HRT:USE HUMAN TRANSDERMALS. WHY RISK TABLETS? BIG PHARMA WINNING THE (DIS)INFORMATION WAR. part 2

 6 June 2010. neil.burman@gmail.com 

Part 1: Transdermal better than oral estrogen for replacement: the importance of appropriate HRT.

Part : 2. DOCTRINE OF CENSORSHIP and DECEIPT;   vs DOCTRINE OF TRUTH:

The Doctrine of Truth (as opposed to theological disputes)  may be said to  date back perhaps 2400 years to Plato.     The  opposite, the Doctrine of Deception and Censorship may have been used by ruthless rulers throughout history  against their own citizens to justify achieving their goals at any cost; and may be said to have been adapted from the Cold War enemy and  perfected by the Kissinger-Bush Regime  in the past 40 years, and  after 9/11 used to  plunge  America into multitrillion dollar futile  war debt  in Iraq and Afghanistan.  The same team (Kissinger’s kindergarten- the  Bushes, Cheney, Rumsfeld, Wolfowitz) has been operating in Washington Administration since the Vietnam war, fuelling failed states- Shock Doctrine  , promoting the policy of two foreign wars for profit at any time,  and disseminating nuclear weapons to Pakistan, South Africa  and many other warring states. .   But fortunately that ruthless regime  was not able to emasculate the USA Supreme Court   as the ANC Govt is now doing in South Africa, and most powermad governments do.

Last week the California Supreme Court under the First Amendment guaranteeing free speech, threw out the FDA Doctrine of Censorship    that bans truthful health claims about supplements, the Doctrine of Deception that corporations, politicians and governments now use to further their own interests not those of  citizens.  

This Court victory  is progress after the revelations  the past year  this column and others review serially about the  endemic Big Pharma-FDA- governments’  fraud around  modern drugs and technology, the ficticious Celebrex-Bextra-Vioxx and swine flue ‘pandemic’  scams,   the flu vaccines,  Tamiflu, and now the Rotavirus vaccine and HPV- Cervix cancer vaccines;   and the evidence-based vindication of Dr Andrew Wakefield’s work and martyrdom on  damage inflicted by multiple early vaccinations . 

For example, the H1N1,  swine flu and HPV vaccines may produce strong antibody reactions, but where is the evidence that they translate longterm into reduction in serious sequelae  from infections and cancer, and without serious long term unintended complications like neurological impairment?  But Big Pharma is immunized at incalculable cost to future taxpayers- by the USA government – (which blissfully passes out of responsibility  after it’s 4 to 8 year term)- which simply denies the possibility of risk and blocks cost-benefit trials of swine flu vaccine lasting  even 2 year let alone 5 years.

The best evidence  summary on Pubmed for HPV vaccine is a 2007 review that serological results “imply they will be effective at preventing related cervical cancer” -on which supposition multimillions of  young women, even  pre-teen boys and grils are being/ have been  coerced into having unproven costly risky vaccines.  Why else would health insurers be still opposing the $360 cost of this unproven vaccination?

The precedents for longterm vaccine adversity are  horrendous, especially after previous misdirected western medical zealotry for  clitoridectomy and oophorectomy for rebelliousness even up to the 1900s, the incarceration in asylums of the ‘mentally ill’  including  dissidents, to mass forced electroconvulsive therapy, to misdirected elective hysterectomy , or gastric surgery for peptic ulcer, to gross antibiotic abuse, to the numerous major complications and deaths after the previous shotgun antiflu vaccination campaign not a few decades ago – never mind the gross disasters from hasty new drug profiteering with eg stilbestrol, the early highdose oral contraceptives,  and  nonsteroidal anti-inflammatories,    discussed in a recent previous column. 

By contast, the USA delayed the introduction of lithium there- heavy competition for it’s new -psychotrope  empire- by refusing  to licence for decades  lithium carbonate- the gold standard for treatment of deadly bipolar disease outside USA- until the great Dane  father of lithium Dr Magnus Schou had been forced to put his patients at risk by doing a double-blind withdrawal trial of lithium; and it refused to licence and encourage  metformin- the gold standard drug (aet 1922) outside USA since the 1950s against type 2 diabetes- until  the UK did the unique double-blind UKPDS trial which confirmed that metformin is the only patent ever drug which reduces both major disease and all-cause mortality by over a third.

And despite major trials for up to 4 years on 4 continents proving that preventative  metformin in overweight  ie prediabetic patients more than halves the occurrence of new diabetes, reduces all markers of lipidemia, inflammation, thrombosis,  and therefore  future mobidity, obesity and mortality, the FDA and the disease industry  still continue the farce of maintaining that metformin is proven solely to treat type 2 diabetes and polycystic ovary syndrome, while they promote new antidiabetics , antilipidemia and  appetitite suppressants  (unproven by longterm trials)  until enough patients suffer and die, like from the glitazones, incretins, statins, fenphen, acarbose, sibutramine, rimonabant,  xenical etc.

 Fortunately the landmark California judgement comes in the same week as UK society questions the abandonment of religious ie moral education in secular UK schools. This hard-won judicial and moral Doctrine of Truth, of Human Rights – which especially USA, UK, Europe and South African governments up to the present  have abandoned this century- applies equally to the BBC ie the media, and Governments/Corporations – politicians and officials; and the Disease Industry including Regulators, Big Pharma and clinicians.

INFORMATION WARFARE AND THE DOCTRINE OF DECEPTION:       Prof   Bill Hutchinson (Chair of the Australian Information Warfare and Security Conference)  in his seminal essay Information Warfare and Deception(2007)   describes  the  Doctrine of  (Dis)Information Deception  strategy  best practiced by the most developed countries that can monitor electonic media and control mass media via small cartels..    He quotes the Soviet Marxist-Lenminist  concept of maskirovka which includes deception, disinformation, secrecy, feints, diversions, imitation, concealment, simulation and security.. Basically, it is concerned with “anything capable of confusing, and therefore weakening, the enemy” (Lloyd, 1997). 

Which strategy the USA politicians  rapidly put to good use from lessons learnt in the wars in Vietnam, Panama, the Falklands , the disaster capitalism used to loot countries by shock doctrine; and so tightly applied in the past decades’ wars started by the Bush quintet;  the senior Bush having served as head of the CIA. Donald Rumsfeld was successively head of GD Searle till it was sold to the rogue company Montsano so deeply involved in the  growth hormone, pesticide and genetically modified seeds scandals, and then of Gilead Science manufacturer of  Tamiflu – one of the scandals of the swine flu scam last year. Dick Cheney was head of Halliburtons, the US corporation most scandalously favoured by $billions in government contracts throughout the Iraq war. Marcia Angell details how Rumsfeld’s GD Searle subsequently ended up as part of Pfizer; and that one recent (2003) annual meeting of PhRMA included Bush senior, the Secretary for Health, former FDA commissioner McClellan and Senator George Allen. So deeply are the politicians involved in Big Pharma.

This deception strategy  has  long and  expertly been deployed by Big Pharma and others in the Disease megaIndustry.   In the marketing health complex context,  for ‘enemy’ read those not in Big Pharma/ Disease technology manufacture-  the reputedly independent regulators, legislators and clients- healthcare insurers/ medical aid groups, State healthcare organizations, healthcare providers and patients. For the other side read ‘Government-Regulator-Diseasemongering- Disease Technology producers- Big Pharma’ complex.  

 It remains to be seen whether, as Hutchinson writes, the government -disease industry -mass media complex uses draconian (paramilitary)  tactics yet again to overturn judical vigilance for free speech and choice.  So after millennia of  promotion, growth  of   truth and human rights as portrayed  and promoted  by rational moderate thinkers (in modern times like Kierkegaard, George Elliot, Winwood Reade, Rudolf Steiner, Churchill, Ghandi, Margaret Sanger,  Linus Pauling, Ivan Illich, Ken Galbraith, Herman Wouk,  and now Naomi Klein, AC  Grayling, and medical Drs   James Le Fanu, Andrew Weil and Marcia Angell) ,   now  greedy  zealots of all faiths – muslim, catholic, baptist, jew, taoist, atheist, – in business,  industry, politics,  and specifically the Disease and Big Pharma  Industry   continue to expand  their   manipulative power and profit interests. 

HARM NOT PREVENTION FROM HIGHTECH SCREENING:

We have watched with increasing alarm the past decades  the proliferation of supposedly preventative costly technology mushroom , from autoanalysers and hypercholesterol mania  to screening for low risk silent breast prostate and colon cancers, to molecular and genetic screening- each multibillion dollar goldmines. .  Now the lid is coming off the obvious, that the more “diagnostic” xray screening eg xray mammography, the more cancer ;

 and the more the preventative new designer synthetic drugs   promoted eg  statins  bisphosphosphonates  nonsteroidal antiinflammatories psychotropes & agents eg genetically modified seeds, the greater the unintended consequences- without any overall benefit except to monster profiteers in  industry and government. 

So the  rights achieved by many martyrs against  European, Muslim, Asian,  panAmerican  and even African ethnic and religious despotism  for so many – especially  for the poor, women and childen, the ill and the aging – in the late 20th century are fast fading as the power-and money-mad destroy the environment, democracy,  health and security including especially for old age  in almost all  countries, on all but two of the continents.

Which brings us back to yesterdays’ ‘ headline health soundbite: to fight for appropriate affordable optimal ie  parenteral balanced human hormone replacement supplements to manage aging.

ABANDONED DOCTRINE OF TRUTH IN MEDICINE: POSTMENOPAUSAL HRT:USE HUMAN TRANSDERMALS. WHY RISK TABLETS? BIG PHARMA WINNING THE DISINFORMATION WAR.

 5 June 2010. neil.burman@gmail.com 

Part 1: Transdermal better than oral estrogen for replacement: the importance of appropriate HRT.

part 2: Information warfare, Big Pharma, Appropriate HRT and the Doctrine of Deception.

PART 1: TRANSDERMAL BETTER THAN ORAL ESTROGEN: THE IMPORTANCE OF APPROPRIATE HUMAN HRT OVER PATENTED MEDICINES :

The  health bite today from the BBC  correctly highlights one of the many critical reasons why appropriate routine Hormone Replacement HRT should be taken permanently  by any route  – but preferably transdermally, not as tablets.  In the appropriate low human dose HRT reduces the natural risk of stroke- and of the far more common chronic major diseases that cripple and kill – ie heart disease, cancer, fractures, dementia..

  But the Menopause Societies (South African, British  and  International) ie BMS , SAMS ,   IMS , and  the BMJ must promptly issue strong statements to the media condemning the BBC again for its typical misleading  elementary misreporting- in this instance  as regards progestins..  

 Transdermal and oral hormone replacement therapy and the risk of stroke: The source report –  this week’s BMJ –   describes HRT use in UK over about 6.7years among postmenopausal stroke victims mean age 70years (50 to 79) compared to matched controls without strokes. But the inexcusable error in the BBC report is that it twice mentions progesterone as being quoted in the BMJ study- which is nonsense.  The  BMJ report never mentions progesterone,  it repeatedly says progestogen -ie synthetics progestins since these were and are deliberately and wrongly routinely prescribed (instead of progesterone) for HRT due to manufacturer-led market disinformation.

  Progesterone is the original natural progestogen- but no major drug company promotes it, so it has been rarely used except by thinking women who prefer to use prime ie human – bioequivalent- hormones!  

In the adjusted risk statistics, lowdose transdermal estradiol TD replacement  0.025 to 0.05mg a day lowered stroke risk by 19%; whereas the average gynecologist’s  arbitrary  patent pharmacological oral  dose (20 to 40fold higher than the TD dose)  of  about 0.625 conjugated estrogens CE equivalent to 1 to 2 mg estradiol OET ) a day increased stroke risk by 35% . Thus, in contrast to lowdose estradiol  TD which reduced the natural stroke rate, OET  and highdose  estrogen TD  increased the stroke rate by 50% – 90%.  

COMPARISON WITH USA WOMENS’ HEALTH INITIATIVE WHI:  the WHI  showed that on premarin 0.625mg/d the absolute  risk of stroke in USA women age 50 to 79years was about 0.3% ie 3 cases per 1000 women per year -but about 45% higher in depressed women on antidepressants. And  depression is even  more common after midlife, especially without HRT. This cohort from the volunteer WHI trial  was a mean of 63years at enrolment ie 7years younger than the British real-life cohort; and since the risk of stroke approximately doubles with every 10 years of aging, the basic risk in the British study women may have been about 5 cases per 1000 per year or 33 per 1000patients over the duration of the British stroke and HRT study. ie annually 4 cases per 1000 on lowdose estrogen TD versus 6 cases per 1000 on OET 

Despite vast evidence  that physiological replacement doses of the human hormone progesterone (the original progestogen in humans) has endless benefits for older adults, doctors, government clinics and committees overwhelminglly still are lead by the marketing hype of drug companies (and the regulators  lobbyists and governments they fund) to use  drugs designed for profit  eg xenohormone progestens that they wish  were and falsely claim are as good as the original one that our bodies produce.

Truthful information  on HRT for women is widely and easily available from even Wiki    and the real authorities like the British and International Menopause Societies, and any university department of gynecology. .   Thus today’s BBC report reflects the BBC’s willful  neglect  of the most basic check of its facts before publishing health bites. In this case, it misleads women that  conventional combined oral HRT (in fact containing the synthetic progestin that most drug companies and doctors encourage women to take) is beneficial in somewhat lowering the risk of stroke  (never mind womb cancer) – whereas such synthetic progestins. progestogens   especially in oral HRT have numerous sinister other adverse effects  eg breast cancer and heart disease,  compared to the numerous proven benefits of  lowdose human progesterone. .

KEEPS: THE DEFINITIVE HEAD-TO-HEAD TRIAL OF APPROPRIATE HRT: ORAL vs NON-ORAL ERT WITH OR WITHOUT PROGESTERONE.: The small but definitive 5year KEEPS double blind randomized controlled trial RCT is now more than half way through and due to report in 2012, comparing the alternative regimes in women in the early menopause (10years younger and less overweight than in WHI) . “ KEEPS is a multicenter trial that will evaluate the effectiveness of 0.45mg of conjugated equine estrogens CEE Wyeth Premarin, a weekly estradiol TD Climara patch delivering 0.05mg estradiol a day -( both in combination with cyclic oral, micronized progesterone (Prometrium Solvay) 200mg for 12 days each month), and placebo”.

Recent information from KEEPS is that it is proceeding smoothly, with no significant differences so far between the three arms- no increase in serious adverse events has yet been seen by the Independent Monitoring Committee in the still unblinded results.  

 Wyeth (now Pfizer since 2009) is not crossfunding KEEPS, although they may be hoping that  their premarin in lower dose will prove to be as safe as or better than estrogen TD in the medium term.. But given the ~70year experience with oral HT mainly premarin 0.625mg/d promoting breast cancer increase (although not mortality) after >12-15years of use , it is remotely unlikely that even ¼ of the long-standard premarin oral dose will prove anywhere as safe and effective as parenteral balanced human hormones for permanent protection in aging women.  One hopes it is, to vindicate the insistence of so many doctors on still prescribing OHT for  even just the first 10 years of menopause,  despite so much damning evidence to the contrary (see this entire website of reviews).

SO WHY PRESCRIBE, RECOMMEND HRT PILLS FOR POSTMENOPAUSAL WOMEN? when hard evidence is that non-oral  balanced human HRT (appropriate estrogen, progesterone and testosterone) is far superior in both benefits and zero risks for women? Whereas it is common cause that conventional oral HT ie about 0.625mg CE or equivalent started at menopause increases the  early risk of dangerous deep vein thrombosis DVT; and  begins to increase the risk of breast cancer to above that of untreated women after a cumulative dose of about 2 – 3 gms oral estrogen – after 10 – 15years ie by prime post retirement midlife in the midsixties. It is only some compensation that other cancers, fractures, ischaemic heart disease, dementia and (breast cancer- and all-cause) mortality, are reduced by appropriate m0dest doses of such OET combined with appropriate progestin; but such regime increases the risk of DVT, gallstones and fatness frailty- increasing body fat with increasing muscle wasting due to collagen loss which also promotes increase in the natural tendency to fractures and urinary incontinence by the midsixties.

Promoters of oral estrogen, bisphosphonates, SERMS,  and strontium cleverly ignore the hard fact that by far the greater risk for aging fractures is not bone density but muskuloskeletal ie failing bone and muscle strength and global co-ordination – which bisphosphonates do nothing to promote, while estrogen and strontium nad SERMS  may promote bone strength but not crucial muscle strength, and SERMS double the laready very high rate of stress urunary incontinence. .

  American major authorities do anything to promote their own commercial interests.  so they have long given their drug regulator the FDA – which is unashamedly paid for by big pharma- unbridled licence to make nonsensical claims and draconian laws. And because drug companies fund the FDA and the lobbyists and legislators in USA to promote their  products, (in a $trillion disease industry – some 8% of American GDP) they have the vast profits to in turn influence medicines regulators and legislators throughout the world to follow their profitable lead.

So  only the FDA and regulators  decide what foods are good for people, what supplements (of microfood stuffs) people may take, and licence designer synthetics for human prescription after trials of only a few months in a few hundred subjects – but insist  that old proven nutritional remedies may not even be claimed to have any health, preventative and therapeutic benefits unless they have undergone massively costly controlled trials that Big Pharma will never fund.

 Their hypocritical deadly nonsense is then to use draconian measures to stop suppliers from making any health claims for even supplements that are well known to be gold standards for prevention and treatment eg fish oil and the scores of other highly effective and safe biologicals- minerals, vitamins, human (eg glucosamine, chondroitin, n-acetylcysteine, coQ10, arginine, carnitine, carnosine), and plant products- that are (co)-hormones, antioxidants, true anabolics, nitric oxide promotors, anti-inflammatories, antidepressants, memory and vision promotors, neurotropics, insulin sensitizers, antiatheroma, hypolipidemic , antimicrobial etc. .  

In fact they now proclaim that citizens may not even buy supplements, foodstuffs  or even legally prescribed compounded hormone creams made from legal components (as are all other prescriptions made by manufacturing pharmacists practicing alone or in Big Pharma), unless the FDA has proclaimed them safe, because “they have not been proven safe”.

 This despite the facts that most  enduringly successful prescription drugs  (eg reserpine, metformin, digoxin, the synthetic progestins) are derived from/ based on successful evolution of and human experience  with the parent supplement eg vitamin, mineral and other biologicals  (eg non-oral progesterone, estradiol, testosterone)  over thousands of years,   and millions of patient years experience  in the past >100years of scientific discovery. 

The Disease Industry- FDA-Big Pharma – organized medicine international network- proclaims that no claims may be made for the benefits of supplements (the vehicles, parents  of most prescription drugs in use) unless they have been tested in rigorous trials to the same standards as designer drugs are recently tested.  

Yet the FDA and regulators allow the marketing of generics- chemical identicals but often far from identical pharmacology and therapeutic action- without clinical trials. Where is the logic for the vendetta against supplement creams  like individually compounded bioidentical hormones that produce measurable physiological levels and appropriate relief?

 This despite the fact that millions of patients have been and continue to be  damaged (iatrogenesis that results in vast numbers of hospital admissions and deaths annually) the past 50 years by drugs promoted by the FDA at the pushing of Big Pharma, based on far too short poor and often fraudulent reports which the drug industry ruthlessly manipulates.

  This led to the disasterous use of stilbestrol in pregnancy from the 1940s to the 1970s;         to the disasterous registration and extensive liberal prescription – in many cases even promotion over-the-counter- of practolol, thalidomide,  chloromycetin and other antibiotics;     potentially fatal unnecessary patent anti-inflammatories  up to the Cox2   inhibitors (eg Vioxx, celebrex) as painkillers;  barbiturates benzos and antidepressants;   lately sulphonylureas and glitazones as firstline drugs for type 2 diabetes instead of the gold standard metformin; new antihypertensive drugs as firstline therapy instead of the goldstandard lowdose amiloretic plus reserpine; appetite-weight suppressants instead of metformin;  bisphosphonates for osteoporosis instead of the goldstandard combined dozen vigorous vitamins minerals and sex hormones that halve all major diseases; and statins for uncomplicated mild to moderate cholesterolemia  instead of goldstandard combined minerals vitamins  metformin and HRT.

  And the simple fact that drug companies  will no longer risk funding head to head trial of one of their profitable drugs against gold standard old drugs or supplements of proven great all-disease medicinal value; since prevention does not pay- only disease pays.

The cost of protectionism for the lucrative Big Pharma industry – for the sake of trade and taxes – is vast  as witnessed by governments sponsoring eg statin , H1N1 flu vaccines , modern antidepressants, bisphosphonates and nonsteroidal anti-inflammatories, and when each of these products of unproven benefit in mass use nets the manufacturers  obscene multibillion dollar profits- in the case of vaccines, with 100%  indemnity guaranteed them at taxpayers’ ie the consumers’  expense!

The lesson from the new UK  study of oral versus estrogen TD is that appropriate ie balanced physiological-dose  human sex hormones are the logical 1st-choice prevention and treatment for postmenopausal women (and their peer mates) – not the multirisk wannabe synthetic substitutes that  Big Pharma keep hammering on the public- new psychotropes, NSAIDs, Cox2 antagonists, statins, bisphosphonates which lack the multisystem benefits of physiological balance of evolution-evolved natural micronutrients ie nutriceuticals.

Part : 2. DOCTRINE OF CENSORSHIP and DECEIPT;   vs DOCTRINE OF TRUTH/… see next review above this.