twelve new papers further confirm the supremacy of the galega plant extract metformin as the most important chronic preventative drug ever, alongside other natural nutrient supplements eg – fish oil, vitamin C, the human hormones vitamin D, sex hormones, thyroid:
1. Aled Rees’ team at Wales’ Cardiff University show in a randomized controlled double-blind RCT that obese women with PCOS (hirsutism and failing periods) even at a mean of 30 (18-35) years have evidence of insulin resistance and early vascular disease; which at their weight around 96.5kg and BMI 35kg/sqm, with waist around 108cm and hips around 120cm, is reversed by metformin: 1500mg/day compared to placebo for 12 weeks reduced weight by 2kg, body fat by 2.5%, waist by 5cm, bloodpressure by 7% and improves circulation; with 18% fall in insulin resistance (HOMA-IR) , 15% fall in free androgen index, and 21% fall in the testosterone: estradiol ratio.
2.A Tehran University Iran (Ashrafinia) RCT (although not big enough to be statistically significant) shows that metformin is 81% better than ovarian diathermy in treatment of PCOS inferrtility.
9. and from Poland (Labuzek) that metformin shows beneficial effects in experimental models of neuroinflammatory diseases like Alzheimers.
10 In June an international team (Jiralerspong ea Texas/ Germany) showed in an observational study that Diabetic patients with breast cancer receiving metformin and neoadjuvant chemotherapy have a 3fold higher pCR pathological complete response rate (24%) than do diabetics not receiving metformin (8%) . In response, Garcia & Tisman from California point out yet another mechanism for this improvement, that metformin induces malabsorption deficiency of both folate and especially metabolically active holotranscobalamin; which is potentiated by neoadjuvant chemotherapy induced lowering of holotranscobalamin., despite apparently normal measured total B12 levels.
14 Nov 2009 METFORMIN THE MASTER DRUG: FIGHTING NEMESIS- ADVANCED GLYCATION ENDPRODUCTS, AGES.
de la Monte and Wands (2005-2008) from Brown University RI crystallize what has been obvious the past decade, that Alzheimers disease- they call it type 3 diabetes mellitus- is not an inevitable part of aging but is as much a product of insulin resistance – the overweight (fast food- couch potato- stress) pandemic- as are all the other interrelated common diseases that constitute premature aging; and therefore even more reason for everyone to take galega/ metformin or other insulin sensitizers preventatively from as young as possible.
And a new novel study from Colorado University (Nadeau ea) again demonstrates that even juvenile type 1 insulin dependent diabetics have insulin resistance and need metformin and all the other anti-AGES agents as well.
The McMaster University (Lemon Boreham and Rollo) landmark Supermouse Trial 5 years ago used a a novel model of our current self-induced obesity pandemic- a transgenic mouse- to show that unlimited access to ‘balanced’ chow grows, learns, sickens and kills far earlier than normal mice – which even in a lab environment neither overeat nor get lazy nor fatten. . But 10fold increase in all the scores of evidence-based conditioned essential micronutrients (that deplete as we age) greatly increased the supermice’s learning, healthspan and lifespan. Such supplements include many powerful natural insulin sensitizers.