PER ASTRA AD ARDUA: ASTROLOGY, STATINS AND SCAMS: AN ASTEROID AND AN AURORA FOR JUPITER.

ASTEROID-   a new study from Harvard and the Cleveland Clinics – boasts the safety and efficacy of achieving very-low low-density lipoprotein cholesterol LDLC with highdose  rosuvastatin Crestor.

But it notes carefully: “on-treatment atheroma volume, change in atheroma volume, and the high % of patients with atheroma regression did not differ by the achieved LDLC level. ”

Since the trial lasted only 2 years in only 471 average obese (BMI ~28.5kg) patients aged around 58yrs, it was far too small and short to determine whether there was any non-cardiovascular benefit or risk from the drug in this high-risk metabolic syndrome population, 95% of whom were hypertensive, 13% diabetic, and who have a high risk of future cancer, dementia, arthritis.

So the only purpose it served is to show that there is no shortterm benefit in highdose versus lowdose statin, in more than moderate lowering of LDLC and raising of HDLC.

In the  AURORA* trial in dialysis patients, “although the mean LDL cholesterol was reduced by 43% in the rosuvastatin arm of the study at three months, no difference in the primary end point (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) was demonstrated at an average follow-up of 3.8 years. [1]

The stark reality- which ( fungus extract) statin, and more modern  antidiabetic drug   proponents hate- is that metformin (a plant derivative)  is the only panacea, patented drug ever that reduces not just heart attack by half in type 2 diabetes but also reduces all-cause mortality by at least one-third; and when used preventitively and to optimal titrated tolerance  in the overweight, reduces the incidence of new diabetes by up to 90%. That just about puts it ahead of vitamin D and fish oil and appropriate HRT  as miracle agents.

And statin proponents  studiously remain silent that while titrated metformin has zero persisting adverse effects in controlled trials of up to 20years, statins produce insidious adverse effects (depression; myo-hepatorenal, memory loss,  non-natural deaths, lowering of sex hormones and erectile function) in up to a quarter of longterm users – with  significant increase in cancer (especially of the breast) when the LDLC is  severely depressed; and fail to influence insulin resistance and diabetes long term.

So, like most statin trials ,  JUPITER and ASTEROID reports  are twisted to promote statins, whereas they do nothing to recommend statins,   show that they are anywhere near as good and safe for longterm mortality reduction as   natural non-patent agents-  metformin, appropriate HRT and eg fish oil and vitamin-mineral-biological-plant supplements – which lack the insidious adverse effects of the statins. .  After some 40 years of use, the only indication for statins remain (if any) those rare patients with severe resistant hypercholesterolemia above perhaps 8 or 10 mmol/L.

And rosuvastatin is apparently the strongest as well as the youngest (preteen) of the current statins; so it should be used in low dose if at all. Have we learnt nothing from stilboestrol, thalidomide, practolol, cerivastatin,  troglitazone, Vioxx?

It is obvious why statin promoters- the manufacturers and their hirelings- continue to spend $millions promoting the $billion statin trade. But it is doctors and especially Authorities- academics and regulators-  who must explain why they are jeapordizing patients’ lives, why  a high percentage of older patients- especially the overweight- are on  the hugely advertized statins when they should be on the safe and highly beneficial metformin, fish oil and the other proven  multibeneficial supplements eg vits-minerals, biologicals including appropriate HRT, and plant extracts.

PER ASTRA AD ARDUA ET LUCRUM:

The promoters of rosuvastatin – Crestor-  make studious use of astrology- ASTEROID, JUPITER, AURORA–  astronomical eponyms – to deviously promote the mystique of statins through their trial titles. But at least astute astrological physicians like Shakespeare’s contemporary  Dr Simon Forman had some justification- there was seldom better treatment at the time, often far worse, and it was harmless (with romantic overtones)  apart from perhaps distracting from more onerous changes in lifestyle and diet; and  had  grains of truth in the as-yet not scientifically recognized planetary and solar-lunar changes in weather etc which influence health..

And rosuvastatin studies only appear on Medline from 2001- barely a decade ago -so there cannot be any longterm experience let alone trial (as there is for metformin)  on this wannabe chronic prevention drug for at least another decade. And  the history of rosuvastatin, it’s discoverer and place of origin, is mysteriously not apparent  on the AstraZeneca or any other website. This at 20 times the cost of simvastatin in UK .

Clearly  Big Pharma and their lobbyists – with the glad connivance of Regulators and Medical Schemes-  – still depend on age-old psychology to bluff doctors let alone patients.

*Aurora has two meanings, both of which are apposite for their use in statin ie Astra-Zeneca marketing :

  • while Astra refers to the wandering stars!

Clearly the manufacturers of Crestor (Astra-Zeneca)  wish  these glowing images and more as their $reward for boosting their protege drug. And Zeneca is also under fire that “Women concerned about breast cancer are being bombarded with a massive advertising campaign for the drug tamoxifen” – which like all other modern drugs has no evidence base for longterm preventitive use.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s