update Dec 2016:  Psychiatrist neuroplastician Dr Norman Doidge in his  books   on How the Brain Changes(prev.  2008); and then  How it  Heals Itself (2015), expands on the brain’s unique capacity to neuroplastically adapt and recover functions either by neuronal regrowth or by finding new pathways. https://www.theguardian.com/books/2015/jan/23/the-brains-way-healing-stories-remarkable-recoveries-norman-doidge-review.   He details numerous landmark discoveries the past century about how diverse integrative noninvasive methods can help the brain heal, including cognitive, nutritional, physical, laser and electro/magnetic innovations- ideally early but even years later, in conditions ranging from cerebral palsy and  autism, to stroke, multiple sclerosis, traumatic brain injury and  blindness,  to Huntingdons chorea,  Parkinsons and dementias. ..

Dr EL Tobinick has since 2003  continued to report progressive improvement in neurological results with peripheral invasive ie perispinal etanercept injection, as his latest paper references.

Over the same ~15year period, Dr CG Coimbra neurologist at Sao Paulo University Brazil has proven increasingly the value of a nutritional regime including megadose vitamin D3 in reversing multiple sclerosis and other serious autoimmune diseases. http://www.vitamindandms.org/researchers/coimbra/ and  https://healthspanlife.wordpress.com/2016/05/17/vitamins-k2-with-d3-the-vitamins-of-the-next-decade/

As Dr Doidge stresses, such landmark innovations  take decades to be confirmed, especially if there are no new devices or drugs that can be marketed to generate  massive profits (and jobs)  for (the Disease) Industry, and governments and politicians via more jobs and taxes. And drug companies and the Disease and Hospital Industry will not fund the necessary major studies without medium-term major profit incentive- especially if the innovations are major prevention and cure, reducing the profitable disease burden. Thus the USA delayed recognizing the major role of metformin and  lithium carbonate  for some 25 years, and medicinal cannabis  for almost 50 years., to protect their moneyspinning Big Pharma new synthetic drug inventions- none of which have proved enduringly safe and effective as have the old natural discoveries.

CNS Drugs.2016 Jun;30:469-80.   Perispinal Delivery of CNS Drugs.   Tobinick EL  Institute of Neurological Recovery.  Florida. Perispinal injection is a novel emerging method of drug delivery to the central nervous system (CNS). Physiological barriers prevent macromolecules from efficiently penetrating into the CNS after systemic administration. Perispinal injection is designed to use the cerebrospinal venous system (CSVS) to enhance delivery of drugs to the CNS. It delivers a substance into the anatomic area posterior to the ligamentum flavum, an anatomic region drained by the external vertebral venous plexus (EVVP), a division of the CSVS. Blood within the EVVP communicates with the deeper venous plexuses of the CSVS. The anatomical basis for this method originates in the detailed studies of the CSVS published in 1819 by the French anatomist Gilbert Breschet; then rediscovered by American anatomist Oscar Batson in 1940; with additional supporting evidence discovered in the publications of American neurologist Corning. Analysis suggests that Corning’s famous first use of cocaine for spinal anesthesia in 1885 was in fact based on Breschet’s anatomical findings, and accomplished by perispinal injection. The therapeutic potential of perispinal injection for CNS disorders is highlighted by the rapid neurological improvement in patients with otherwise intractable neuroinflammatory disorders that may ensue following perispinal etanercept administration.      full paper and published peerreviewed references at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920856/


upodate 2009:  Regrettably, there is as yet apparently  no objective group clinical follow-up from Dr Tobinick or other clinicians since  this column’s first report of February 2008 of instantaneous and sustained improvement in Alzheimer’s disease after etanercept (Enebrel) perispinal injection.

Search under this heading on Pubmed and Google  yields material clinical papers only by the originator of this therapy Dr Tobinick.

The videos on line of February 2009 giving up to 4 year  followup of  a few individual recovered patients are exciting  but anecdotal.

Professor Tobinick’s February 2009 paper describes elegant  imaging of localization of labeled etanercept in the brain in a rat model.

Search of Pubmed for etanercept adverse effect in other uses  yields a report of two cases of sarcoidosis after etanercept; almost doubling of the risk of cancer; and increased occurrence of psoriasis.

But in a relentless deadly disease like Alzheimers, these adverse events pale into significance if etanercept reverses  dementia’s progression  for even a few months, when no modern designer drugs in common use show any significant benefit as opposed to adverse effects.

So further report on durability of improvement from etanercept in Dr Tobinick’s group of patients, and confirmation of this application by other clinicians, is keenly awaited by many.

How many success stories have there been with etanercept in AD, against how many AD patients treated with etancercept in total? and what has been the average duration of remission compared to those not treated with the magic injection?

There is  one report giving  more recent detail, apparently a newspaper interview  dated 12 April 2008 that  says Dr Tobinick’s group has  “treated around 50 patients at a private clinic by injecting  etanercept, into the spinal column in the neck. .They claim 90 per cent respond to the treatment, usually within minutes.”

This response rate and speed bears out the promise of their report of a year ago; but there is no mention of such results on their website or anywhere else.  Hence the skepticism of the British Alzheimer Society’s website .



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