Vits B12, D3, FISH OIL, BRAIN DEVELOPMENT and PRESERVATION

Yesterday we reviewed the new data promoting vitamin D to the top pole position.
Supplements are about far more than promoting development, “wellbeing”, antiaging and longevity. None of these matter unless there is a good mind and spirit to work, enjoy and manage all.

 

                        While  correcting common Vitamin D3 deficiency may be the most important step needed against all common diseases including the commonest- vascular, infections, cancer, osteoporosis, autoimmune,
since the brain – mind, mood and function- is arguably the heart and meaning of  being and living, v
itamin D and it’s major food carrier fish oil’s  most important role may be in promoting and protecting the brain from conception to dotage.
                McCann and Ames from San Francisco’s Oakland Research Institute recently published an exhaustive review of vitamin D deficiency and brain dysfunction  in infant and adult rodents and humans; concluding that “while evidence has not yet fully satisfied causal criteria, vitamin D3 supplementation of at-risk groups including nursing infants, the very darkskinned,  and the elderly, appear warranted; with suggestion by some authorities that the threshold  for diagnosing vitamin D3 deficiency be raised even above a blood level of  77.5nmol/L  31ng/ml.   


Psychiatrist John Cannell also from California argues: “Apparent increase in prevalence of autism  the last 20 years corresponds with increasing advice to avoid the sun, advice that has probably lowered vitamin D levels and  lowered activated vitamin D  calcitriol levels in developing brains. Severe vitamin D deficiency during pregnancy disrupts dozens of proteins involved in brain development and leads to rat pups with increased brain size and enlarged ventricles, abnormalities similar to those found in autistic children… . Children with vitamin D deficient rickets have several autistic markers that apparently disappear with high-dose vitamin D treatment. Estrogen and testosterone have very different effects on calcitriol’s metabolism, differences that may explain the striking male/female sex ratios in autism. Calcitriol down-regulates brain production of inflammatory cytokines  that have been associated with autism. Consumption of vitamin D containing fish during pregnancy reduces autistic symptoms in offspring. Autism is more common with  impaired UVB penetration such as  in poleward latitudes, urban areas, high air pollution, high rainfall, and  dark-skinned persons (in whom maternal vitamin D deficiency is exceptionally common). Simple Gaussian distributions of the enzyme that activates neural calcitriol combined with widespread gestational and/or early childhood vitamin D deficiency may explain both the genetics and epidemiology of autism. If so, much of the disease is iatrogenic, brought on by medical advice to avoid the sun.”
 
Herndon et al from  University of Colorado ask  recently:  Does Nutritional Intake Differ Between Children with Autism Spectrum Disorders and Children with Typical Development?  they compared “Consumption of macro- and micronutrients and food group servings by children with autism spectrum disorders (ASDs; n = 46) and typical development (n = 31); Children with ASDs consumed significantly lower dairy servings, which deficit  persisted after controlling for child age and sex and parental dietary restrictions, and excluding children on the gluten-free casein-free (GFCF) diet. Large proportions of children in both groups did not meet national recommendations for daily intake of fiber, calcium, iron, vitamin E, and vitamin D.”
 
Now Vogiatzoglou, Smith ea from the Universities of Oxford, UK; Oslo, Norway; &  Australia publish “a prospective 5year followup  of 107 community-dwelling volunteers aged 61 to 87 years without cognitive impairment at enrollment, showing that  decrease in brain volume was greater among those with lower vitamin B12 levels and higher plasma homocysteine  levels at baseline, associations significant after adjustment for age, sex, creatinine, education, initial brain volume, cognitive test scores,  blood pressure, ApoE 4 status,  homocysteine and folate. Using the upper (for the vitamins) or lower tertile (for the metabolites) as reference in analysis and adjusting for the above covariates, vitamin B12 in the bottom tertile (<308 pmol/L) was associated with  sixfold increased rate of brain volume loss. High levels of homocysteine or low levels of folate were not associated with brain volume loss. Low vitamin B12 status should be further investigated as a modifiable cause of brain atrophy and of likely subsequent cognitive impairment in the elderly”. .
 
So while there are dozens of crucial factors before and after conception  in (neurological) structure, function and memory development and preservation-  from balanced foods and lifestyle including avoiding  trauma, smoking, alcohol, irradiation, microbial  and heavy metal excess to optimal nuturing and body composition including bloodpressure control- 
           safely measuring vitamin B12 and D levels, and  safely supplementing  low EPA eicosapentanoic acid EPA and docosahexanoic acid DHA ( as cod liver 4g/d) as well as low B12 and D levels into the  top quintile  of the “normal” range for pale skinned people in temperate climates- with eg vitamin D3  10 000iud and B12  eg 0.5mg/d-  may radically reduce the incidence of not just  childhood developmental, learning, behaviour, mood and aging memory/dementia problems.
        It will  also reduce  lifelong susceptibility to infection, fertility and growth disorders, osteoporosis, arthritis, common cancers (breast, prostate, skin),  autoimmune, vascular and skin diseases, and  premature aging. 
 
          These simple supplements- for below R2.50  a day,  US$10  a month-  may indeed radically improve fertility,  pregnancy, childhood,  work and successful aging outcomes.
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