It takes no rocket science to see how increasing fatness parallels increase in all common degenerative diseases, from diabetes to high blood pressure to heart, circulatory, brain, arthritic – inflammatory, depressive, memory, vision and cancer (Barclay 2008; Hjartåker 2008 ) problems. Major earlier studies in eg the Netherlands, USA and UK confirmed this statistically.
Similarly, the century-old knowledge that diabetics are more prone to cancer has been confirmed in several countries (Czyzyk 2000), including endometrium, breast, bladder, liver, kidney, prostate, pancreas and colon.
A Hong Kong study (Yang ea 2008) registered and followed up new diabetics from 1995; showing after a mean of 4.9yrs that from the age of 35yrs on, compared to nondiabetic controls, standardized cancer incidence in male diabetics at 0.93% was 36% higher, and in diabetic women at 0.62% was 27% higher – ie diabetes in even the mildly average overweight (mean BMI 25 instead of the optimal 21-22kg/sqm) increases cancer risk by about a third.
But more important, what can doctors do to reduce this increasing co-morbidity?
Only dictatorships – prisons, not doctors – can compel patients to eat, drink, exercise sensibly and not smoke. But for the disaster capitalists that now dominate the world, vice and disease pay too well. So the Disease Industry tries progressively to suppress nutritious natural preventative and curative supplements while promoting sloth, gluttony and nonprescription sales of the biggest killers eg sugar, tobacco, alcohol, and noncurative designer drugs eg non-steroidal anti-inflammatories and statins.
STATINS increase inflammation in muscle and liver, show no independent benefit in lowering C-reactive protein CRP , and no benefit against cancer:
In the 2001 Texas Lovastatin trial in 6600 well older people, there was no reduction in all-cause mortality, but statin associated with 41% more cancer deaths;
in the 2002 PROSPER pravastatin trial in 8800 well people 70-82yrs old, new cancers were 25% higher on statin than on placebo;
in the 2005 Oxford CTT metaanalysis in 90 000 people, statins did not lower the incidence of cancer in 14 statin trials; but in the older –
in the 2008 Baltimore metaanalysis in 51 300 adults from 60years up, statins associated with 6% more cancer.
METFORMIN STUDIES since 1922 have shown increasing evidence that metformin not only about halves the incidence of new diabetes and of deaths in diabetics,
it also significantly reduces CRP , reduces the risks of osteoporosis fractures (Vestergaard 2008; Kanazawa 2008); and cancer in rodent and human cell lines, and
in the UKPDS (1998) after about 13yrs associated with about 1/3 less all-cause and cancer deaths;
in the Dundee Tayside (Evans 2005) diabetic study metformin, associated with up to 40% less cancer in those on the longest. and highest metformin consumption,
in the Canadian (Bowker 2006) diabetic study metformin associated with half the mortality and 30%% less cancer than on other antidiabetics. .
The Hong Kong 2008 study confirmed the well-known U shaped curve relationship between serum cholesterol, cancer and death, in fact a V relationship with LDL cholesterol, with the lowest cancer and death rate at an LDLC of about 3.28mmol/- the risk rising linearly with LDLC below 2.8 or above 3.8mmol/L.
Statins lower LDL cholesterol and cardiovascular disease /mortality but not adiposity, insulin resistance, diabetes, fractures, cancer, depression or non-vascular morbidity-mortality.
Metformin about halves new diabetes, lowers obesity, insulin resistance, lipidemia, reproductive problems, ischaemic heart disease and in diabetics lowers both vascular and cancer events and mortality.
So it is insulin sensitizers (metformin or a non-prescription mix of a score of natural ones including fish oil ), not statins or nonsteroidal anti-inflammatories that must be promoted over-the-counter to combat the pandemic of overweight- reproductive- diabetes- vascular- malignant and arthritic-immune diseases that is progressively curtailing by decades the healthspan of the haves.
See the HRT and supplement papers below, and the recommended condition-specific supplement product information.. For specialist internist consultation on appropriate supplements including HRT for individual circumstances, email your concise health details to firstname.lastname@example.org ..