21 Sept 2014  update:  a new USA study Littlejohns, Llewellyn ea,  confirms  low Vitamin D  risk of dementia and Alzheimer disease.Neurology. 2014 Sep;83:920-8, that in 1658 USA elderly followed for ~5.6years, dementia more than doubled in those with baseline vit D level below 10ng/ml compared to those above 20ng/ml.

This confirmed the 2012 Angers study Annweiler Beauchet ea that the elderly with the highest  quintile of vitamin D intake had only 23% of the risk of AD of those in the lowest quintile.

So while there are numerous obvious reversible and avoidable causes for dementia, – syphilis, stroke, malnutrition   and poisoning known for millennia – on Pubmed vitamin D and dementia link  dates  back to 1968.  Vitamin D3 and  vitamin B12 supplements are two of the cheapest and safest to give since even a monthly or 3monthly shot – if not simply oral vit D3 orally fortnightly- can maintain good repletion, quality of life and longevity; while hugely reducing multisystemic diseases and infections. . .

Wikipedia still says soberly Currently, no medications have been shown to prevent or cure dementia.    By that they mean designer for-profit prescription drugs.

24 March 2008:  it took 8 authors (funded by the U.S. and Ontario Ministries of Health and McMaster University) 19 pages in a leading journal this month to show what has been obvious the past decade from Medline –
that the modern anti-dementia drugs produce clinically significant adverse effects but zero clinically meaningful benefit or remission/slowing of degenerative dementias.

This article highlighting the futility and irrelevance (as in arthritis; type 2 diabetes; osteoporosis; lipid- vascular disease, cancer) of modern designer drugs for prevention of everyday chronic degenerative aging diseases is truly POEM – Patient-Orientated Evidence that Matters

But does it need a massively costly study to show what has been obvious from every single published trial of these drugs?

Surely these anti-dementia drugs should be banned since their risks outweigh their benefits?
Talk about fiddling for a living.

Yet while appropriate long term sex hormone therapy the past >50 years for both sexes clearly lower (by perhaps 40%) the risk of dementia, fractures, vascular disease and all-cause premature deaths, with negligible risks, bureaucrats continue to insist that it must not be used longterm until major trials have proven it- which trials will never be done because these supplements are long out of patent.

One must ask again whether the bureaucratic bodies (professional associations, universities, Regulators, medical schemes, politicians) that strive to have effective safe supplements (HRT, vitamins, minerals, biologicals including fish oil, herbs) severely restricted – or made prescription only – are fearlessly independent of the massive financial inducements, lobbying power of the New Drug Industry on behalf of their wannabe substitutes for old supplements that work?

http://www.annals.org/cgi/content/full/148/5/379 Ann Intern Med. 2008 Mar 4;148:379-97.
Effectiveness of cholinesterase inhibitors (donepezil, galantamine, rivastigmine, and tacrine) and memantine for treating dementia: evidence review for a clinical practice guideline. Raina P, Santaguida P, Ismaila A, Patterson C, Cowan D, Levine M, Booker L, Oremus M. McMaster University, Hamilton, Ontario, Canada.



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