Association of pioglitazone treatment with decreased bone mineral density

In this Danish trial in just 16 weeks, pioglitazone associated with 1 to 1.4% loss of bone density compared to placebo.

Is this surprising considering that this group of drugs has never been shown to have the safe anabolic benefits of metformin?- which reduces fat mass and increases lean mass, and growth in teenagers with polycystic ovary syndrome.

Metformin reduces lipidemia, new diabetes by half and in diabetics almost halves mortality and all major chronic degenerative diseases. By contrast, like sulphonylureas, gliptins, appetite suppressants and other wannabe metformin substitutes the glitazones and statins have never been shown to have global benefit long term on all-cause mortality and all common aging degenerative diseases – let alone the incredible safety of metformin when used sensibly. Nor has insulin when added as last-ditch therapy in resistant type 2 diabetes.

So it is increasingly medical negligence to prescribe anything but metformin to tolerance early on and permanently in the overweight, including in common maturity-onset diabetics and those with common lipidemia and hypertension, if lifestyle, diet and a blend of natural supplements (including appropriate parenteral sex hormone replacement in men and women with such imbalance) that reduce insulin resistance are inadequate.
There are no long term contraindications to metformin adjusted to tolerance with sensible monitoring.



  1. Pingback: INDEX OF RECENT MAIN TOPICS « Healthspanlife – the Official Life! Blog

  2. I do agree with all of the ideas you have introduced in your post.
    They’re really convincing and will definitely work.
    Nonetheless, the posts are too short for newbies.
    Could you please prolong them a bit from subsequent time?
    Thanks for the post.

  3. I comment each time I appreciate a article on a site or if I have something to add to the discussion. Usually
    it’s triggered by the sincerness displayed in the post I read.
    And after this article THE HAZARDS OF MODERN DRUGS:
    | Healthspanlife – the Official Life! Blog. I was excited enough
    to write a comment 😛 I actually do have 2 questions for you if you usually do
    not mind. Is it only me or does it seem like some of these remarks come across as if they are
    left by brain dead folks? 😛 And, if you are
    posting at additional online sites, I would
    like to follow you. Would you list all of your public sites like your
    twitter feed, Facebook page or linkedin profile?

  4. It’s awesome to pay a visit this website and
    reading the views of all mates about this piece of writing, while I am also keen of getting knowledge.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s