Healthspanlife - the Official Life! Blog

Entries tagged as ‘statins’

CRIES OF INFECTION WOLVES, AND OFFICIAL ONGOING DENIAL OF NECESSARY PREVENTION:

April 27, 2008 · 1 Comment

It’s tragicomedy that the BBC – the quintessential British spokespersona – laments NHS woes: * UK c.diff deaths ‘rising sharply’ * “The equivalent of one person an hour dies in hospital from clostridium difficile, figures suggest.”

And yet Authorities there and mostwhere are still in denial about enforcing simple safe low-cost multi-system prevention – in this instance to keep people out of bed and hospital, off antibiotics.
Authorities- regulators, politicians, the Tax Man – benefit as hugely from disease as do their fairy godmother the Disease Industry- the Drug conglomerates and their researchers and lobbyists, private hospitals, medical schemes - that pay them handsomely and creates myriad factories and jobs.

So because it is not profitable, Prevention Does Not Pay, no matter that it adds decades to health:

*There is no move to ban smoking, to make it (and sale, and allowance thereof) a criminal offence.

*No move to immediately jail drunken drivers for a long time, and on second offence permanently confiscate their driving licence and ban them permanently from current and future public office and public vehicle driving, be they judges or janitors, cabinet ministers or cabbies.

*The banning of deadly polluting coal-and oil-powered vehicles and major electricity sources has been blocked for decades by the endlessly greedy and ruthless oil-based industry magnates, despite the fact that these finite energy sources are desperately needed for other purposes. Now the world faces immediate famine because the oil-based transport-and energy behemoths (who have blocked investment in natural – solar - energy for decades) are paying bigger dollars for crop and marine resources as energy supplies than most consumers can afford to pay for these finite resources as food.

*No official move to acknowledge that the best drugs for both prevention and chronic treatment are the long-proven natural low-cost vigorous safe daily doses of a few score appropriate micronutrient supplements - vitamins (~15), minerals(~10) and biologicals (human and other species’) that are increasingly inadequate in the food chain in longer-lived increasingly overweight stressed humans facing worsening man-made epidemics and environmental disaster.

*No serious move yet by the US FDA- the chief protector of the new drugs industry of the west -English- Europe- Japan – (against the interests of consumers) to enforce integrity, insist that no chronic designer drugs for the chronic major common degenerative diseases be released for general use until they have been proven both at least as safe and effective as those already existing and effective, in major randomised controlled trials of a mean of at least 8years, head to head against both older designer drugs, and long-proven natural drugs, for similar purpose, in those diseases.

*The past decade alone has seen condemnation of myriad unproven unnecessary and risky released drugs –
on Wikipedia alone at least a dozen - eg Propulsid; cerivastatin; Vioxx; pemoline; benzbromarone; torcetrapib; and the discrediting of the non-steroidal anti-inflammatory drugs as no better - and potentially more hazardous than- appropriate cortisone and micronutrient use, and
newer designer antidepressants and anticlotting agents as less safe and effective than appropriately used older ones;

*the unnecessary anti-osteoporosis bisphosphonates that are increasingly associated with the very long-bone fractures they are supposed to prevent;

*and most especially the wannabe oral anti-diabetic anti-atheroma and anti-obesity drugs – statins, rimonabant, glitazones, meglitanides and sulphonylureas - as inferior to and less safe than metformin, the 85year old plant extract which is the only designer drug ever proven as invaluable panacea in a 20year RCT, tested against sulphonylureas, but not against all other modern designer drugs which (as in more recent studies) have never been shown to meaningfully reduce all-cause morbidity and mortality as does metformin.

The until-recent FDA haste to licence new drugs after scanty trials was reminiscent of the criminal conspiracy between the FDA and industry that licenced the already contested diethylstilbestrol Chicago trial of 1950- and kept that drug on the market another 25years after it was discredited. And it was in stark contrast to the FDA (to protect USA drug companies) blocking drugs already in highly effective use elsewhere for decades, like lithium carbonate, metformin and betablockers.

Since no drug corporations promote the out-of-patent old and proven agents, authorities cannot afford to promote truth - that the only remedies for chronic prevention that lower all-cause disease and mortality by between a third and a half - overweight, obesity, diabetes, cancer, hypertension, arthritis, osteoporosis fractures, vascular disease, acute infections, depression, dementia - are:

-fish oil a few grams a day- which also drastically lowers behavioural and learning disorders;
-a lowcost simple blend of a few score other proven natural micronutrients - the fifteen vitamins, ten minerals and the human / other species’ biologicals including herbs;
-metformin titrated to tolerance about 2.5gms a day, for both prevention and treatment of overweight, diabetes type 2 and most major chronic degenerative diseases; &
-appropriate conservative balanced sex hormone replacement in most older men and women, as proven in the landmark Womens’ Health Initiative and Finnish Oulu randomised controlled trials, and numerous other studies in major centres in North America, UK, Europe, Australia and South Africa, since 1953.

It is a tenet of endocrinology for the past 60 years that all major hormone deficiencies should be replaced permanently and physiologically with the same human hormones, yet there are still those, even medical specialists, who would deny this to those most in need – from middle age onwards, especially women. At least some of these specialists have the honesty to disclose that they are well paid by drug compnies to be advocates and trialists for the wannabe designer drugs to supplant the old.

Recognition of appropriate measured low cost HRT and the other proven listed supplements for all aging people would of course rob the drug industry of perhaps 90% of it’s market for it’s wannabe designer substitutes that the FDA allows to be marketed prematurely until enough people die of their complications or shortcomings.

In fact, while no study shows that any modern drug for common chronic degenerative disease prevention does any overall - mutidisease- good, reduces all-cause mortality, those who promote and practice such published truth – that the old is better - are threatened with prosecution.

Categories: Alzheimer's · HRT · cancer · diabetes prevention · osteoporosis · overweight prevention · supplements
Tagged: , , , , , , , , , , , , , , ,

more bisphosphonate, statin complications:

March 19, 2008 · 1 Comment

note the latest designer drug complications-

severe diffuse pain from statins and biphosphonates,

interstitial lung disease, and tendon rupture, from statin:

FDA ALERT [1/7/2008]: ” FDA is highlighting the possibility of severe and sometimes incapacitating bone, joint, and/or muscle (musculoskeletal) pain in patients taking bisphosphonates. Although severe musculoskeletal pain is included in the prescribing information for all bisphosphonates, the association between bisphosphonates and severe musculoskeletal pain may be overlooked by healthcare professionals, delaying diagnosis, prolonging pain and/or impairment, and necessitating the use of analgesics.”
read on at http://www.fda.gov/CDER/drug/InfoSheets/HCP/bisphosphonatesHCP.htm

CONCERNS ABOUT STATINS: COMPLICATIONS AND SIDE EFFECTS: TreatmentUpdate 150 Volume 17 Issue 4 2005 June/July http://www.catie.ca/tu.nsf/acdff2c60dab4741852571b60051c9fe/d5b21cf52ec5187785257066005ce726!OpenDocument Currently available statins include the following:
atorvastatin (Lipitor)
fluvastatin (Lescor and Lescor XL)
pravastatin (Pravachol)
rosuvastatin (Crestor)
simvastatin (Zocor)
“Statin safety controversy
The safety of statins has become controversial in recent years. In 2001, another powerful statin, cerivastatin (Baycol, Lipobay), had to be withdrawn from sale because, particularly at higher doses, it was linked to the development of muscle weakness and kidney damage. The manufacturer of cerivastatin, Bayer, was subsequently listed as a defendant in 14,700 lawsuits around the world. Nearly 3,000 of these have been settled at a cost of $1.3 billion US.

“Crestor was licensed in high-income countries over the past couple of years in this environment of lawsuits and heightened safety concerns. As a result, perhaps its side effects have come under more scrutiny than expected.

“An American consumer advocacy group, Public Citizen, has criticized regulatory authorities in that country for the approval of Crestor. Moreover, Public Citizen has asked the Food and Drug Administration (FDA) to ban the sale of Crestor because of concerns about its safety. However, the FDA has refused to do so.

Warnings from regulatory agencies
In 2004, several regulatory agencies in Canada and the European Union sent letters to physicians warning them to begin therapy with Crestor at a low dose of the drug and reminding them about possible side effects. Last year, Canada’s Federal Health Ministry also sent an advisory to patients asking them to review the use of Crestor with their doctors. In July 2005, Health Canada has issued yet another advisory to patients related to the use of statins, warning them about health conditions that may make users more susceptible to side effects from statins (a report on this appears later in this issue of TreatmentUpdate).
http://www.arc.org.uk/news/article/18492474 Statin use linked to tendon complications. Statins, popularly prescribed treatments for lowering cholesterol, have been linked to tendon complications, according to a new study published in the journal Arthritis Care & Research.

A team of French scientists found that although very rare, there was evidence of a link between statins, which are widely used and have been demonstrated to be safe in large clinical trials, and musculoskeletal complications, such as tendon impairment.

Studying patient records from the Rouen University Hospital database between 1990 and 2005, 4,597 side effects were associated with statins, most of which were extremely mild.

Approximately two per cent of these, identified in 96 cases, were attributed to tendon complications. Symptoms usually occurred within eight months of beginning statin therapy and included tendonitis and occasionally ruptured tendons.

“Our study suggests that regular tendinous clinical examination may be required in statin-treated patients, particularly during the first year following statin therapy initiation,” the authors reported.

Although the researchers did not know how statins are linked to tendon injury, they suggested that blocking cholesterol synthesis could reduce the cholesterol content of tendon cell membranes, making them less stable.

Title MHRA: class side-effects of statins
Date Published 04/02/2008 http://www.nelm.nhs.uk/Record%20Viewing/vR.aspx?id=589805
Reporter initials Nicola Pocock Hospital Pharmacist
Source MHRA Drug Safety Update; February 2008
” The February 2008 issue of ‘Drug Safety Update’ from the MHRA notes that product information for statins is being updated to reflect a number of different side-effects which appear to be a class-effect of these medicines. The following prescribing advice is given:

• Patients should be made aware that treatment with any statin may sometimes be associated with depression, sleep disturbances, memory loss, and sexual dysfunction

• Statins may very rarely be associated with interstitial lung disease. Patients should seek help from their doctor if they develop presenting features of interstitial lung disease such as dyspnoea, non-productive cough, and deterioration in general health (e.g., fatigue, weight loss, and fever)”

note: the MHRA list convenently ignores the insidious muscle damage- myopathy- kidney- liver damage that statins cause”.

These heavily prescribed drugs are never needed for mild-to-moderate lipidemia, or for osteoporosis, since there are better safer natural long-proven drugs.
ndb

Categories: Uncategorized
Tagged: , , , , ,

STATINS- THE HARMFUL (AND LARGELY UNNECESSARY) MARKETTED CHOLESTEROL-LOWERING DRUGS

February 5, 2008 · No Comments

THE HARMFUL (AND LARGELY UNNECESSARY) MARKETTED CHOLESTEROL-LOWERING DRUGS

A new study from Texas University (Riechman SE ea, Statins and dietary and serum cholesterol are associated with increased lean mass following resistance training. J Gerontol A Biol Sci Med Sci. 2007;62:1164-71) shows that the cholesterol-busting statins significantly increase muscle mass. But the authors carefully analyze why this did not translate to increase in muscle strength. In fact many studies show that these drugs cause muscle damage- pain and fatigue, weakness – in up to 25% of users – especially with exercise - perhaps especially where there is pseudohypertrophy, which is probably what Riechman ea saw, muscle swelling from statin-induced damage..

This contrasts with physiological human androgen (testosterone) which cause genuine increase in both lean mass and strength (independent of exercise, and far more so with exercise), whether in bodybuilders or in the frail elderly (Bhasin ea 1996 et seq). Statins predictably cause the reverse- muscle damage pseudohypertrophy associated with significant fall in androgen levels, depression, impotence, lung, liver and kidney damage…

Contrary to the hype of the marketing industry (which funds the Regulators – FDA, Governments, Academics and the vast Disease Industry through “research” grants, taxes, jobs and congresses), there is no good reason to take or prescribe routine statins since evidence does not support their benefit EXCEPT in rare severe hypercholesterolemia. Cholesterol is not the cause of disease, it is a key biological building block – common mild to moderate lipidemia is mostly a manifestation of simple dysmetabolism, mostly insulin resistance from lack of exercise and a few score micronutrients that are safely, easily and cheaply supplemented .

The creation of the non-existent hypercholesterolemia epidemic to sell statins is well described by Dr James le Fanu in The Rise and Fall of Modern Medicine: Abacus, London, 1999;
and was mimicked a decade later by Pfizer in fabricating a pandemic of impotence to create a market for the potentially blinding/ killer blockbuster arrhythmogenic Viagra sildenafil – which is rarely needed if the common relative androgen and other micronutrient deficiency of aging is simply screened for and appropriately corrected at trivial cost and no risk, with global health benefits.
It is common cause that sexuality (in both genders) starts declining as the serum testosterone falls below the average level of healthy youth – but Pfizer and the FDA have colluded tenaciously to conceal this fact in refusing for years to disclose the mean and range of testosterone levels of the men who were included in the infamous Viagra trials. Yet simple testosterone, magneium and fish oil are the major antiarrhythmic drugs- and most people die suddenly, from arrhythmia as the terminal event.

Antimicrobials aside, statins and all other modern drugs for chronic prevention are designed to target symptoms, not the root cause of diseases- so modern chronic drugs do not significantly reduce all-cause mortality and common major diseases of aging. The last thing the trillion-dollar Disease Industry wants is effective cheap prevention that can reduce by 90% the need for modern drugs, high-tech investigations and admissions to hospitals.

So the Disease Industry and it’s myriad beneficiaries – shareholders and staff, the FDA, Governments, academics, clinicians and politicians everywhere- desperately want to suppress and regulate access to and supply of the simple safe combination of natural proven drugs – the nutritional supplements like appropriate niacin, fish oil, and a few score other vitamins, minerals and biologicals (mostly also insulin sensitizers like appropriate sex hormone replacement/HRT, metformin/ galega etc) Together these unprofitable old drugs do vastly better in halving all common major chronic degenerative diseases of aging than fraudulent wannabe designer patent drugs like statins (and non-steroidal, anti-osteoporosis, anti-diabetics, anti-obesity, anti-depressants, and hormone substitutes) that are allowed by Regulators (like Congress and politicians everywhere, the tool of the lucrative drug industry – Only Disease Pays) to poison millions - the Innocent Survivors - Elaine Feuer’s famous 1997 expose..

AND Just in case you thought statins were “benign” drugs…. from the University of Cape Town Drug Info Centre-
The February 2008 issue of ‘Drug Safety Update’ from the MHRA notes that product information for statins is being updated to reflect a number of different side-effects which appear to be a class-effect of these medicines. The following prescribing advice is given:

• Patients should be made aware that treatment with any statin may sometimes be associated with depression, sleep disturbances, memory loss, and sexual dysfunction

• Statins may very rarely be associated with interstitial lung disease. Patients should seek help from their doctor if they develop presenting features of interstitial lung disease such as dyspnoea, non-productive cough, and deterioration in general health (e.g., fatigue, weight loss, and fever)

so, why take statins? unless you have severe lipidemia, stop them, take supplements that are far better. But discuss this with your doctor.

ndb

Categories: HRT · diabetes prevention · overweight prevention · supplements
Tagged: , , , , , , , ,