THE ANTIOXIDANT ANTIAGING CHIEF HUMAN HORMONE MELATONIN DELAYS / LESSENS MENOPAUSE, PARKINSONS, GALLSTONES, HYPERTENSION, HEADACHE, SEASONAL AFFECTIVE DISORDER, AGING, ALZHEIMERS, CANCER, INSOMNIA,, OSTEOPOROSIS & GASTRO-OESOPHAGEAL REFLUX; ONLY EXCESS LOWERS MOOD AND LIBIDO. .
Since melatonin improves sleep & serotonin level, it not surprisingly lowers LH luteotropic hormone and thus libido in the pharmacological doses marketed (3mg) .
Surprisingly, there are only 8 papers on melatonin and aging human sexual activity on Pubmed search..But is it a surprise that there are 186 melatonin AND sexual activity papers on Pubmed since 1992? including many on a designer melatonin agonist agomelatine- of which one of the latest – in Prescrire a month ago- concludes: “agomelaline new drug. Adverse effects and no proven efficacy;.. Very high doses of agomelatine are oncogenic in animals. The risk in humans is not known. Dizziness, gastrointestinal and cutaneous disorders have been observed. Agomelatine is probably hepatotoxic“.
PHYSIOLOGICAL HORMONE BALANCE VERSUS SYNTHETIC DESIGNER SUBSTITUTES:
But there are lots of self-reports on Google confirming what physiology tells us, that hormone balance is what matters.
Doctors (and hence patients) choose at their peril - at the behest of Big Pharma, heavy marketing- to ignore physiology – what nature teaches us about optimal function . Big pharma made a killing before WW2 with the isolation, patenting and mass sales of natural supplements eg hormones starting with thyroid and insulin. But these soon ran out of patent, so Big Pharma has zealously employed massive armies of researchers and lobbyists to develop and promote synthetics cribbed from natural products ie synthetic designer drugs. The high number of $billion-a-year raincheck drugs is a tribute to their clever marketing and sleight-of-hand concealement of adverse reports – but not for the many thousands of patients who have suffered or died as a result of eg fenfluramine, Vioxx, Prepulsid and lately sibutramine, rimonabant, glitazone, and vaccines….
But Industry has not yet succeeded in generating a synthetic designer ie patentable form of thyroid hormone to exploit the millions with thyroid deficiency, nor a substitute for the human heart-made hormone digoxin, which – like the uniquely lifesaving plant extract metformin- defy the inventiveness of Big Pharma’s ruthless quest for megabuck profits.
Big Pharma wants us to forget that all modern drugs for chronic use were and are based on ancient endogenous and mineral/plant based drugs .
The chief brain antidepressant HORMONES serotonin ie its precursors (5H)tryptophan and other natural antidepressant like St John’s wort and marine omega3; and the chief brain anxiolytics GABA and progesterone, and harmless plant anxiolytics like valerian, were soon supplanted by synthetic antidepressants, barbiturate-benzodiazepine and progestin designer drugs. Industry has exploited the growing dialysis market by promoting grossly costly designer synthetic- not human- erythropoeitin analogues.
These designer drugs have been so cleverly marketed by Big Pharma – and thus politicians, governments which Big Pharma massively funds directly and via taxes and job promises – that for chronic use let alone acute illness they have almost wiped out the use of highly effective remedies used for millennia. eg Lithium and metformin were ignored by the FDA for 25 years despite being the gold standard elsewhere for bipolar and type 2 diabetes respectively. For common hypertension, rauwolfia-reserpine is still the goldstandard bedrock treatment in a dose of 0.1mg/day or less , combined with the also-suppressed perfect synthetic (potassium-magnesium- calcium conserving saluretic) vasodilator amiloretic amilozide in low dose. But the antihypertensive drug industry has bought so many in the antihypertensive trials and regulatory hierarchy that Europe and Britain have abandoned reserpine; and in South Africa these “experts” beholden to Big Pharma have removed these gold standard drugs from firstline therapy recommendations and even from the formulary of state clinics because they were too cheap at below a US$ a month. .
The Chinese already 2500 years ago were using gender-specific sex human hormones derived from the ‘sublimation’ of youthful human urine to treat gender-specific diseases and deficiencies. But since the extraction of sex hormones from the urine of humans in this age of viral and prion plagues (let alone the aesthetic and logistic problem of buying billions of gallons of human urine each year) is not on, Wyeth – with the increasing monopolistic complicity of the FDA-USA government- simply substituted human hormones by xenohormones- horse estrogens (from the mass farming of tethered catheterized mares) and synthetic progestins- for both contraception, and HRT for women. Hence the problems for older women of the Womens’ Health Initiative which used exclusively Wyeth’s PremPro.
And industry attempts to keep a stranglehold on the vast diabetes market by continually synthetising new depot forms of human insulin; and synthetic alternatives to the gold standard and only plant-derived antidiabetic prohormone (metformin, in use for well over 50 years, the only drug ever that has been tested in a 20year randomized controlled trial, and proven to be the only prescription drug that reduces all major diseases and thus deaths by almost 50% -) by continually bombarding the market with largely unnecessary synthetic designer drugs to discourage use of metformin, diet and lifestyle change. These include new sulphonylureas, acarbose, glitazones and now gliptins, none of which have undergone longterm trials, and which uniformly prove (unlike established old drugs) to have major adverse effects even at registered doses.
Like amphetamines, orlistat and rimonabant have had to be progressively restricted- sibutramine is the latest to be cancelled last week in Europe. due to adverse effects that the suppliers finally failed to prevent becoming common knowledge. Is it surprising that the USA FDA – which runs on the massive funding of and input from Big Pharma- has still not suspended sibutramine use there?
And surprise surprise- Wikipedia dismisses metformin for weight loss with one reference, although there are scores of trials including major 3-5year prevention trials on three continents that show that metformin use in the overweight (even BEFORE diabetes occurs) produces both significant fat loss and approximate halving (30 to 80% reduction) in new diabetes and new cancer.
And wiki confirms that while the human hormones leptin, amylin and gliptins-incretins- work in synergy with all other hormones, micronutients to potently regulate optimal sugar and fat and energy metabolism, none of them have been marketed as the natural forms- that is the last thing that Big Pharma – the FDA- Uncle Sam wants when with some effort they can already market designer adaptations to produce more golden $billion raincheques.
This despite the fact that Turek’s 2010 USA transcontinental trial showed recently in rodents that combination injection of the natural hormones amylin and leptin “decreased food intake (by 26%) and reduced body weight (by 15%) and epididymal fat (by 78%)”. 15% of 100kg body mass is 15kg weight loss“. A year before, Ravussin ea published the 6 month trial in obese humans of the designer derivatives of leptin and amylin confirming that the patented combination indeed lowered body weight by 12.7%.But the common adverse effect of the injection was nausea.
This farcical commercial merry-go-round - which puts patients at grave risk- is despite the fact that there are dozens of safe proven natural ie unpatentable antidiabetic insulin sensitizers/ obesity-reversing supplements freely available, from garlic and fenugreek to galega officinalis, gymnema, coleus, calcium, chromium, zinc and vitamin D3.
Hypnotics including melatonin promote sleep, not sex. Hence sex works best after sleep rest ie well after midnight, early morning. But unlike melatonin, designer synthetic hypnotics have dangerous side-effects and addiction problems, without any longterm benefits.
Clearly for anyone not in an institution or at risk of cancer, melatonin dose should be kept as low as is prudent to optimize sleep – not sedate.
This dose may be as low as 0.05mg/night- hence dose should be titrated upwards from a pinch to the average optimal of 0.25mg/night, but as high as is well tolerated without hangover/daytime drowsiness.
So for the hyperanxious-anxiety-panic disorders, melatonin may well best be taken in the morning at low dose, and early evening to unwind.
That low dose reverses impotence in rats is not surprising- 10 to 100mcg/kg as used in rodents equates to between 1-10mcg/kg in humans ie 0.05 to 1mg in adults.
Studies show that the right dose for sleep in humans is about 0.1 to 0.3mg – not the 3mg caps/pills that are unthinkingly marketed, prescribed and swallowed by unwise patients.
Melatonin in excess can worsen depression and cognition; and even be arousing.
but since it generally improves sleep and growth and reproduction and energy balance and immunity and bloodpressure and cancer control and anorexia – fragility reversal,
it should equally clearly be supplemented at night in physiological dose ie 0.05 – 1mg- combined with especially vitamin D3, and during the day or for an hour before sleep with bright (sunshine or artificial light) exposure, which dramatically improves Parkinsons disease..
LEVELS OF MELATONIN AND LIGHT:
The recent Bronowski Institute study shows how bright fluorescent light (does a TV or computer screen count? – surely?) should be encouraged for an hour before bedtime since it markedly reduces Parkinsons; but in older people should then be followed by a melatonin supplement dose for all the antiaging reasons. As Rabbi Michoel Gourarie writes in Personal Growth, turning on a light in the dark- even the one small candle of ancient times- can do as much to cheer up one or a host of people.
So especially in institutions sleep should be preceded by bright light for an hour before lights out.
The most most important aspect for us all is sequential light (both via stimulation and via vitamin D – soltriol -from sunlight) ; and then darkness for sleep’s melatonin value in insomnia & fatigue and especially against autism, ADHD, cancer, hypertension, diabetes (insulin sensitizer ), & especially for retarding menopause ie infertility.
The recent trials data increases greatly the potential of melatonin against premature aging ie against cancer as well as against gonadopause that was already widely promoted 15 yrs ago by Regelson, Colman and Pierpaoli - In 1995 Pierpaoli in The Melatonin Miracle summed up how melatonin given to aging mice maintained youthful size gonads, significantly higher sex hormones, and extended their healthspan and lifespan by 30% ie to a century in human terms.
The first 7.5year case followup of melatonin benefits in delaying menopause came from Poland 2 years ago; but already in 2005 an Italian team Bellipanni ea showed in a 6month study that melatonin 3mg/day “abrogates hormonal, menopause-related neurovegetative disturbances and restores menstrual cyclicity and fertility in perimenopausal or menopausal women. At present we assert that the six-month treatment with MEL produced a remarkable and highly significant improvement of thyroid function, positive changes of gonadotropins towards more juvenile levels, and abrogation of menopause-related depression.”
Previously in 1992, Sandyk ea in New York proposed that “There is evidence that pineal melatonin is an anti-aging hormone and that the menopause is associated with a substantial decline in melatonin secretion and an increased rate of pineal calcification.” . And in 1984 Aleem ea had shown “Suppression of basal luteinizing hormone concentrations by melatonin in postmenopausal women.” ie that supplemental melatonin can suppress rising LH – although the primary cause of menopause is gonadal aging- exhaustion,- which in both men and women leads to the compensatory rise in LH if the pineal and pituitary glands are themselves still capable of responding to feedback. The primary cause of hot flashes is due largely to falling estrogen level, with all other menopause symptoms being caused by gonadal hormone exhaustion. But Bellipanni’s 2005 study showed that melatonin supplement could produce better gonadal and thyroid hormone output.
So all aging folk should take the combined hormones vitamin D3 about 5000iu/day, and melatonin, building slowly to perhaps 1 - 3mg at night, from age 30yrs if not earlier; but with cancer, under medical supervision, building to vit D3 10 00 to 50 000iu/day ( monitoring the serum calcium) and melatonin to perhaps 40mg/d – plus a titrated dose of the anticancer prohormone metfornin. .